Results 91 to 100 of about 19,190 (266)

The genomic landscape of chronic lymphocytic leukemia: clinical implications [PDF]

, 2013
A precise understanding of the genomic and epigenomic features of chronic lymphocytic leukemia (CLL) may benefit the study of the disease’s staging and treatment.
Campo, Elías, López Otín, Carlos, Quesada Fernández, Víctor, Ramsay, Andrew John, Rodríguez Martínez, David, Suárez Puente, Xosé Antón   +5 more
core   +2 more sources

SF3A3 Drives Tumorigenesis in Endometrial Cancer by Enhancing c‐FOS Expression and Represents a Potential Therapeutic Target

Advanced Science, EarlyView.
The role of splicing factor 3A subunit 3 (SF3A3) in driving endometrial cancer (EC) progression and potential therapeutic interventions. SF3A3, a core component of the U2 small nuclear ribonucleoprotein (U2 snRNP), is upregulated in endometrial cancer (EC) and promotes tumor growth and cisplatin resistance. RNA‐binding protein immunoprecipitation (RIP)
Wei Yu, Yi Gu, Hengrui Zhang, Wunan Huang, Lei Sun, Liangjian Ma, Xiaolei Liang, Lexin Liu, Guiping Chen, Weihua Wang, Zhongkai Cao, Xue Li, Xiangjun Chen, Lidan Hu   +13 more
wiley   +1 more source

Myelodysplastic Neoplasms (MDS) with Ring Sideroblasts or SF3B1 Mutations: The Improved Clinical Utility of World Health Organization and International Consensus Classification 2022 Definitions, a Single-Centre Retrospective Chart Review

Current Oncology
Myelodysplastic neoplasms (MDS) with ring sideroblasts (RS) are diagnosed via bone marrow aspiration in the presence of either (i) ≥15% RS or (ii) 5–14% RS and an SF3B1 mutation.
Shamim Mortuza, B. Chin‐Yee, Tyler E. James, I. Chin-Yee, Ben D Hedley, J. Ho, Lalit Saini, A. Lazo-Langner, Laila Schenkel, P. Bhai, B. Sadikovic, Jonathan Keow, Nikhil Sangle, Cyrus C. Hsia   +13 more
semanticscholar   +1 more source

The SF3B1 K666 Hotspot Mutation Confers Unfavourable Disease Risk across Major Myeloid Neoplasm Subgroups

Blood, 2023
SF3B1 is the most prevalent splicing factor mutated in myeloid neoplasms, detected in 20-30% of patients with myelodysplasia (MDS) and associated with a milder disease phenotype.
Jennifer O Sullivan, Amy Wood, S. Wen, A. Hamblin, Sonia Fox, Christina Yap, M. McMullin, Nicholas C. P. Cross, C. Harrison, A. Mead   +9 more
semanticscholar   +1 more source

Low rate of calreticulin mutations in refractory anaemia with ring sideroblasts and marked thrombocytosis [PDF]

, 2014
Broséus, J., Lippert, E., Harutyunyan, A.S., Jeromin, S., Zipperer, E., Florensa, L., Milosevic, J.D., Haferlach, T., Germing, U., Luño, E., Schnittger, S., Kralovics, R., Girodon ...
Broséus, Julien, Harutyunyan, S., Jeromin, S., Lippert, A. S., Luño Fernández, Elisa   +4 more
core   +1 more source

Systemic Mastocytosis in 910 Patients: Prognostic Contribution of the International Consensus Classification in the Context of the Mayo Alliance Prognostic System

American Journal of Hematology, EarlyView.
Overall survival data among 910 Mayo Clinic patients with systemic mastocytosis stratified by the International Consensus Classification (ICC) and the Mayo Alliance Prognostic Scoring System (MAPS). ABSTRACT The current study includes 910 patients with systemic mastocytosis (SM) seen at the Mayo Clinic from 1968 to 2024.
Fnu Aperna, Maymona G. Abdelmagid, Mahesh Kumar, Joseph H. Butterfield, Thanai Pongdee, Cecilia Y. Arana Yi, Mrinal S. Patnaik, Daniel A. Arber, Attilio Orazi, Dong Chen, Kaaren K. Reichard, Naseema Gangat, Animesh Pardanani, Ayalew Tefferi   +13 more
wiley   +1 more source

The E592K variant of SF3B1 creates unique RNA missplicing and associates with high-risk MDS without ring sideroblasts

Research Square, 2023
Among the most common genetic alterations in the myelodysplastic syndromes (MDS) are mutations in the spliceosome gene SF3B1. Such mutations induce specific RNA missplicing events, directly promote ring sideroblast (RS) formation, generally associate ...
W. Dalton, Inyoung Choi, Jonathan P. Ling, Jian Zhang, Eric Helmenstine, W. Walter, Riley E. Bergman, C. Philippe, James L. Manley, K. Rouault-Pierre, Bing Li, D. Wiseman, Madhu M Ouseph, E. Bernard, X. Li, T. Haferlach, Salman Fazal, Tania Jain, C. Gocke, A. DeZern   +19 more
semanticscholar   +1 more source

Modeling SF3B1 Mutations in Cancer: Advances, Challenges, and Opportunities [PDF]

Cancer Cell, 2016
In this issue of Cancer Cell, Obeng et al. identify the consequences of expressing the most common mutation in the spliceosomal gene SF3B1 on hematopoiesis. The knockin mouse model described represents a valuable tool to dissect the effects of SF3B1 mutations on transformation, splicing, and less well-characterized functions of SF3B1.
Omar Abdel-Wahab, Daichi Inoue
openaire   +3 more sources

Clinical impact of the subclonal architecture and mutational complexity in chronic lymphocytic leukemia [PDF]

, 2017
This study was supported by the Instituto de Salud Carlos III (ISCIII) PMP15/00007; Ministerio de Economía y Competitividad (MINECO) SAF2015-64885-R; Generalitat de Catalunya AGAUR 2014-SGR-795; and Gilead Spain (GLD15/00288).
Clot, G., Delgado, J., López Otín, Carlos, Nadeu, Ferrán, Suárez Puente, Xosé Antón   +4 more
core   +2 more sources

Impact of Cytogenetic Response to Therapy on Long‐Term Survival in Acute Myeloid Leukemia

American Journal of Hematology, EarlyView.
ABSTRACT Prognostication in acute myeloid leukemia (AML) relies on clinical, molecular, and cytogenetic factors. In this retrospective study, we examined the impact of different levels of cytogenetic response on overall survival (OS) and event‐free survival (EFS) in AML.
John Hanna, Emily C. Zabor, Moath Albliwi, Jessica El‐Asmar, Daniel P. Nurse, Ameed Bawwab, Hasan Abuamsha, Yomna Abu‐Farsakh, Heya Batah, Asad Rauf, Joy Nakitandwe, David S. Bosler, Akriti G. Jain, John C. Molina, Sophia Balderman, Abhay Singh, Aaron T. Gerds, Sudipto Mukherjee, Ronald M. Sobecks, Anjali S. Advani, Hetty E. Carraway, Caroline Astbury, Moaath K. Mustafa Ali   +22 more
wiley   +1 more source