Results 91 to 100 of about 16,653 (197)

Improvements in Real‐World Survival in the Setting of a Recent Paradigm Shift in Acute Myeloid Leukemia Treatment

European Journal of Haematology, EarlyView.
ABSTRACT Therapeutic options for newly diagnosed (ND) acute myeloid leukemia (AML) have increased in recent years, leading to a shift in the treatment paradigm from conventional, intensive chemotherapy toward targeted and less intensive therapy. Since 2017, there has been a surge in FDA approvals for novel therapies, including small molecule inhibitors
Thuy N. Ho, Patrick Willard, Graeme F. Murray, Li Liu, Nolan Wages, Hyun Lee, Keri R. Maher   +6 more
wiley   +1 more source

Comparing Nonparametric Bayesian Tree Priors for Clonal Reconstruction of Tumors

, 2014
Statistical machine learning methods, especially nonparametric Bayesian methods, have become increasingly popular to infer clonal population structure of tumors.
Deshwar, Amit G., Morris, Quaid, Vembu, Shankar   +2 more
core   +1 more source

Significance of Myelodysplasia‐Related Mutations and the Genetic Landscape of Acute Leukemias of Ambiguous Lineage

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT The recent fifth edition WHO classification and ICC classification systems have moved further toward genetically defined classifications of acute leukemias. Both now recognize myelodysplasia‐related (MR) mutations as defining of MDS‐related AML (AML‐MR).
Timothy J. Kirtek, Olga K. Weinberg
wiley   +1 more source

SF3B1 and BAP1 mutations in blue nevus-like melanoma [PDF]

Modern Pathology, 2017
Blue nevi are melanocytic tumors originating in the cutaneous dermis. Malignant tumors may arise in association with or resembling blue nevi, so called 'blue nevus-like melanoma', which can metastasize and result in patient death. Identifying which tumors will behave in a clinically aggressive manner can be challenging.
Griewank, Klaus, Müller, Hansgeorg, Jackett, Louise A., Emberger, Michael, Möller, Inga, van de Nes, Johannes, Zimmer, Lisa, Livingstone, Elisabeth, Wiesner, Thomas, Scholz, Simone L., Cosgarea, Ioana, Sucker, Antje, Schimming, Tobias, Hillen, Uwe, Schilling, Bastian, Paschen, Annette, Reis, Henning, Mentzel, Thomas, Kutzner, Heinz, Rütten, Arno, Murali, Rajmohan, Scolyer, Richard A., Schadendorf, Dirk   +22 more
openaire   +2 more sources

Advancing the therapeutic effectiveness of paclitaxel in chronic lymphocytic leukemia through the simultaneous inhibition of NOTCH1 and SF3B1

Cancer Cell International
Background Chemoresistance is still a significant obstacle to cancer therapy. Overexpression of the splicing factor 3b subunit 1 (SF3B1) and neurogenic locus notch homolog protein 1 (NOTCH1) factors is typically found in chronic lymphocytic leukemia (CLL)
Shiva Abolhasani, Armin Mahmoud salehi Khesht, Atefeh Khodakarami, Ali Masjedi, Bentolhoda Rashidi, Sepideh Izadi, Fatemeh Karimian Noukabadi, Vahid Karpisheh, Khatereh Torabi Poudeh, Pooya Jalali, Zahra Salehi, Rafieh Bagherifar, Seyyed Sina Hejazian, AliAkbar Movassaghpour, Abbas Ali Hosseinpour Feizi, Farhad Jadidi   +15 more
doaj   +1 more source

Allele Loss and Reduced Expression of CYCLOPS Genes is a Characteristic Feature of Chromophobe Renal Cell Carcinoma

Translational Oncology, 2019
Copy-number alterations Yielding Cancer Liabilities Owing to Partial losS (CYCLOPS) genes have been recently identified as the most enriched class of copy-number associated gene dependencies in human cancer.
Riuko Ohashi, Peter Schraml, Aashil Batavia, Silvia Angori, Patrik Simmler, Niels Rupp, Yoichi Ajioka, Esther Oliva, Holger Moch   +8 more
doaj   +1 more source

Genome-scale analysis identifies paralog lethality as a vulnerability of chromosome 1p loss in cancer. [PDF]

, 2018
Functional redundancy shared by paralog genes may afford protection against genetic perturbations, but it can also result in genetic vulnerabilities due to mutual interdependency1-5.
Berger, Ashton C, Bhatia, Sangeeta N, Buss, Colin G, Carr, Steven A, Cherniack, Andrew D, Choi, Peter S, Hahn, William C, Krill-Burger, John M, Lage, Kasper, Malolepsza, Edyta, Meyerson, Matthew, Nogueira, Marina F, Pedamallu, Chandra Sekhar, Schenone, Monica, Shih, Juliann, Strathdee, Craig A, Tamayo, Pablo, Tanenbaum, Benjamin, Taylor, Alison M, Tsherniak, Aviad, Vazquez, Francisca, Viswanathan, Srinivas R, Wawer, Mathias J   +22 more
core   +1 more source

Common Hematologic Emergencies—Acute Promyelocytic Leukemia and Microangiopathic Hemolytic Anemias—A Pivotal Role of Clinical Laboratory

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Hematologic emergencies are urgent health conditions which result in significant mortality and morbidity unless timely therapeutic measures are taken. Therapeutic success depends on their timely and accurate recognition by hematology laboratory services.
Ganna Shestakova, Nicolas Ulrich Edgar, Anton V. Rets   +2 more
wiley   +1 more source

Antitumor activity of splicing inhibitor pladienolide B in erythroleukemia: a study in cell lines [PDF]

, 2015
Trabalho final de mestrado integrado em Medicina (Hematologia/Biologia Molecular), apresentado à Faculdade de Medicina da Universidade de Coimbra.The splicing of pre-mRNA into functional mRNA, carried out by the spliceosome, represents a crucial step ...
Petronilho, Sara Lopes
core  

Jerantinine A induces tumor-specific cell death through modulation of splicing factor 3b subunit 1 (SF3B1) [PDF]

, 2017
Precursor mRNA (pre-mRNA) splicing is catalyzed by a large ribonucleoprotein complex known as the spliceosome. Numerous studies have indicated that aberrant splicing patterns or mutations in spliceosome components, including the splicing factor 3b ...
Bradshaw, Tracey D., Chung, Felicia Fei-Lei, Hii, Ling-Wei, Kam, Toh-Seok, Leong, Chee-Onn, Lim, Kuan-Hon, Mai, Chun Wai, Raja, Vijay Joseph, See, Sze-Jia, Tan, Boon-Shing, Tan, Perry Faith Tze Ming, Tan, Si Hoey, Tan, Yuen-Fen, Wong, Li-Zhe, Yam, Wai Keat   +14 more
core   +1 more source