Results 101 to 110 of about 16,653 (197)
Targeted therapy and outcome in chronic lymphocytic leukemia [PDF]
Despite major advances, chronic lymphocytic leukemia (CLL) is still considered incurable. Fludarabine refractory patients and those with TP53disruptions have a particularly poor prognosis.
Eketorp Sylvan, Sandra
core +1 more source
Abstract Flow cytometry (FCM) is a co‐criterion in myelodysplastic neoplasms (MDS) diagnostics, currently not used for prognostication. This study aimed to develop an FCM‐score predicting overall survival (OS) in MDS to improve early clinical patient prognostication.
Aida Santaolalla +14 more
wiley +1 more source
Analysis of SF3B1 mutations in monoclonal B‐cell lymphocytosis [PDF]
[No abstract available]
Mariangela Greco +11 more
openaire +4 more sources
Metastatic disease in polyploid uveal melanoma patients is associated with BAP1 mutations [PDF]
PURPOSE. Most of the uvea melanoma (UM) display a near-diploid (normal, ~2N) karyotype with only a few chromosomal changes. In contrast to these simple aberrations 18% of the UM samples show a polyploid character (>2N) and this was associated with an ...
Beverloo, H.B. (Berna) +12 more
core +1 more source
State‐of‐the‐Art Strategies for Circular RNA in Cancers: Opportunity and Challenge
Overview of circular RNA in tumors. ABSTRACT Circular RNAs (circRNAs) are characterized by their covalently closed structure, remarkable stability, and precise spatiotemporal regulation, evolving from once‐overlooked transcriptional byproducts to pivotal molecular regulators.
Zehao Ding +6 more
wiley +1 more source
WHO classification of skin tumours: key updates in the fifth edition
This review article summarizes the key updates in the 5th edition of the WHO Classification of Skin Tumours. It provides an overview of the major changes and new entities specific to the skin section, covering areas such as epidermal, melanocytic, mesenchymal and other tumours. The 5th edition of the World Health Organization Classification of Tumours (
Gabrielle Goldman‐Lévy +29 more
wiley +1 more source
Somatic mutations of the RNA splicing machinery have been recently identified in myelodysplastic syndromes. In particular, a strong association has been found between SF3B1 mutation and refractory anemia with ring sider-oblasts, a condition characterized
Ilaria Ambaglio +13 more
doaj +1 more source
SF3B1 mutation and ATM deletion codrive leukemogenesis via centromeric R-loop dysregulation
RNA splicing factor SF3B1 is recurrently mutated in various cancers, particularly in hematologic malignancies. We previously reported that coexpression of Sf3b1 mutation and Atm deletion in B cells, but not either lesion alone, leads to the onset of ...
Martina Cusan +18 more
doaj +1 more source
Mutational landscape of RNA-binding proteins in human cancers [PDF]
RNA Binding Proteins (RBPs) are a class of post-transcriptional regulatory molecules which are increasingly documented to be dysfunctional in cancer genomes. However, our current understanding of these alterations is limited.
Bhat-Nakshatri, Poornima +4 more
core +2 more sources
SF3B1: hotspot mutazionale nei prolattinomi [PDF]
G. Mantovani, F. Mangili
openaire +2 more sources

