Results 101 to 110 of about 21,005 (271)

Expression levels of SF3B3 correlate with prognosis and endocrine resistance in estrogen receptor-positive breast cancer [PDF]

, 2015
De novo or acquired resistance to endocrine therapy limits its utility in a significant number of estrogen receptor-positive (ER-positive) breast cancers.
Badve, Sunil, Goswami, Chirayu P., Gu, Xiaoping, Gökmen-Polar, Yesim, Janga, Sarath Chandra, Nallamothu, Gouthami, Neelamraju, Yaseswini   +6 more
core   +1 more source

SF3B1-mutated chronic lymphocytic leukemia shows evidence of NOTCH1 pathway activation including CD20 downregulation

Haematologica, 2020
Chronic lymphocytic leukemia (CLL) is characterized by low CD20 expression, in part explained by an epigenetic-driven downregulation triggered by mutations of the NOTCH1 gene.
Federico Pozzo, Tamara Bittolo, Erika Tissino, Filippo Vit, Elena Vendramini, Luca Laurenti, Giovanni D’Arena, Jacopo Olivieri, Gabriele Pozzato, Francesco Zaja, Annalisa Chiarenza, Francesco Di Raimondo, Antonella Zucchetto, Riccardo Bomben, Francesca Maria Rossi, Giovanni Del Poeta, Michele Dal Bo, Valter Gattei   +17 more
doaj   +1 more source

Mis-splicing of Mitotic Regulators Sensitizes SF3B1-Mutated Human HSCs to CHK1 Inhibition

Blood Cancer Discovery
Precise gene editing uncovers mis-splicing of BUBR1 and CDC27 in human SF3B1-mutant HSPCs, leading to activation of mitotic checkpoint and rendering the cells sensitive to CHK1 inhibitor prexasertib.
Martina Sarchi, Courtnee A Clough, Edie I. Crosse, Jason Kim, Laura D Baquero Galvis, Nelli Aydinyan, Rachel Wellington, Feini Yang, A. Gallì, J. P. Creamer, Sintra Stewart, Robert K Bradley, L. Malcovati, Sergei Doulatov   +13 more
semanticscholar   +1 more source

Erythroid Differentiation Enhances RNA Mis-Splicing in SF3B1-Mutant Myelodysplastic Syndromes with Ring Sideroblasts

Cancer Research, 2023
Ring sideroblast isolation combined with state-of-the-art multiomics identifies survival mechanisms underlying SF3B1-mutant erythropoiesis and establishes an active role for erythroid differentiation and ring sideroblasts themselves in SF3B1-mutant ...
P. Moura, Teresa Mortera Blanco, I. Hofman, G. Todisco, W. Kretzschmar, A. Björklund, M. Creignou, Michael Hagemann-Jensen, Christoph Ziegenhain, David Cabrerizo Granados, I. Barbosa, G. Walldin, M. Jansson, Neil Ashley, A. Mead, V. Lundin, M. Dimitriou, T. Yoshizato, P. Woll, Seishi Ogawa, R. Sandberg, S. W. Jacobsen, E. Hellström-Lindberg   +22 more
semanticscholar   +1 more source

Subclonal evolution involving SF3B1 mutations in chronic lymphocytic leukemia [PDF]

Leukemia, 2013
Mutations in genes encoding the spliceosome machinery recently have been described in hematological malignancies,1, 2 particularly in myelodysplastic syndrome (MDS) and chronic lymphocytic leukemia (CLL). These mutations can occur in genes encoding different components of the spliceosome.3 However, the most frequent of such mutations observed in CLL ...
Schwaederlé, M, Ghia, E, Rassenti, L Z, Obara, M, Dell' Aquila, M L, Fecteau, J F, Kipps, T J   +6 more
openaire   +2 more sources

Systemic Surveillance Guidelines for Uveal Melanoma: A Systematic Review

Clinical &Experimental Ophthalmology, EarlyView.
ABSTRACT Background Uveal melanoma (UM) is the most common primary intraocular tumour. Despite effective local therapies, UM has a high risk of metastatic recurrence, most frequently to the liver. A significant proportion of patients treated definitively for primary UM eventually experience metastatic disease. Systemic surveillance to detect recurrence
Farzana Y. Zaman, Aisha Ghaus, Mark Shackleton, Damien Kee, Anthony M. Joshua, Roderick O'Day, Malaka Ameratunga   +6 more
wiley   +1 more source

Characterisation of the biflavonoid hinokiflavone as a premRNA splicing modulator that inhibits SENP [PDF]

, 2017
We have identified the plant biflavonoid hinokiflavone as an inhibitor of splicing in vitro and modulator of alternative splicing in cells. Chemical synthesis confirms hinokiflavone is the active molecule.
Abovich, Arango, Asai, Boswell, Chabot, Chen, Chiba, Cox, Cox, Cáceres, David, Ferhi, Fong, Gao, Gao, Harborne, Hendriks, Hett, Kaida, Kalva, Konarska, Kotake, Kumar, Lamond, Lamond, Larrayoz, Le, Lee, Lomenick, Makarov, Naryshkin, O'Brien, Pai, Pan, Papasaikas, Papasaikas, Pelisch, Pozzi, Rappsilber, Ratni, Sakai, Tammsalu, Tammsalu, UniProt Consortium, Wahl, Webb, Wen, Wiśniewski, Woll, Wu, Xiao, Zuo   +51 more
core   +5 more sources

Concurrent Mutations in SF3B1 and PHF6 in Myeloid Neoplasms

Biology, 2022
It has been reported that gene mutations in SF3B1 and PHF6 are mutually exclusive. However, this observation has never been rigorously assessed. We report the clinicopathologic and molecular genetic features of 21 cases of myeloid neoplasms with double ...
Zhuang Zuo, L. Jeffrey Medeiros, Sofia Garces, Mark J. Routbort, Chi Young Ok, Sanam Loghavi, Rashmi Kanagal-Shamanna, Fatima Zahra Jelloul, Guillermo Garcia-Manero, Kelly S. Chien, Keyur P. Patel, Rajyalakshmi Luthra, C. Cameron Yin   +12 more
doaj   +1 more source

Improvements in Real‐World Survival in the Setting of a Recent Paradigm Shift in Acute Myeloid Leukemia Treatment

European Journal of Haematology, EarlyView.
ABSTRACT Therapeutic options for newly diagnosed (ND) acute myeloid leukemia (AML) have increased in recent years, leading to a shift in the treatment paradigm from conventional, intensive chemotherapy toward targeted and less intensive therapy. Since 2017, there has been a surge in FDA approvals for novel therapies, including small molecule inhibitors
Thuy N. Ho, Patrick Willard, Graeme F. Murray, Li Liu, Nolan Wages, Hyun Lee, Keri R. Maher   +6 more
wiley   +1 more source

Jerantinine A induces tumor-specific cell death through modulation of splicing factor 3b subunit 1 (SF3B1) [PDF]

, 2017
Precursor mRNA (pre-mRNA) splicing is catalyzed by a large ribonucleoprotein complex known as the spliceosome. Numerous studies have indicated that aberrant splicing patterns or mutations in spliceosome components, including the splicing factor 3b ...
Bradshaw, Tracey D., Chung, Felicia Fei-Lei, Hii, Ling-Wei, Kam, Toh-Seok, Leong, Chee-Onn, Lim, Kuan-Hon, Mai, Chun Wai, Raja, Vijay Joseph, See, Sze-Jia, Tan, Boon-Shing, Tan, Perry Faith Tze Ming, Tan, Si Hoey, Tan, Yuen-Fen, Wong, Li-Zhe, Yam, Wai Keat   +14 more
core   +1 more source