Results 121 to 130 of about 12,272 (217)
SF3B1 haploinsufficiency leads to formation of ring sideroblasts in myelodysplastic syndromes
, 2016 Whole exome/genome sequencing has been fundamental in the identification of somatic mutations in the spliceosome machinery in myelodysplastic syndromes (MDSs) and other hematologic disorders.
Koseki, Haruhiko +22 more
core +1 more source
Hematological Oncology, Volume 44, Issue 5, September 2026.ABSTRACT FLT3‐ITD occurs in approximately 20%–25% of cases of adult AML and is associated with increased relapse risk and shorter survival. FLT3‐ITD status informs AML risk at diagnosis, but its dynamic changes during disease evolution are not well defined.
Xavier Cheng‐Hong Tsai +14 more
wiley +1 more source
MedComm, Volume 7, Issue 9, September 2026.This work synthesizes recent insights into the pathological roles of cyclins and cyclin‐dependent kinases (CDKs) across human cancers, highlights state‐of‐the‐art innovative approaches (especially targeted degradation and redistribution of CDK/cyclin proteins) for cancer therapy, and outlines future directions for CDK/cyclin‐related biomedical research.
Suya Zheng +9 more
wiley +1 more source
RNA‐Binding Proteins: Function, Biological Mechanisms, and Therapeutic Opportunities
MedComm, Volume 7, Issue 9, September 2026.RNA‐binding proteins (RBPs) regulate RNA stability, localization, translation, and splicing through intrinsic binding domains and interactions with diverse cellular partners. Their competitive and cooperative networks shape disease‐related RNA programs, especially in cancer.
Ling Li, Xiuli Yan, Qing Ji, Hui Zhang
wiley +1 more source
Myelodysplastic/myeloproliferative neoplasm with SF3B1 mutation and thrombocytosis (MDS/MPN-SF3B1-T) is a clonal hematopoietic stem cell disorder with overlapping features of myelodysplastic neoplasms (MDS) and myeloproliferative neoplasms (MPN ...
Divoux, Marion
core +3 more sources
SUGP1 loss drives SF3B1 hotspot mutant missplicing in cancer
Cell ReportsSummary: SF3B1 is the most frequently mutated splicing factor in cancer. Such mutations cause missplicing by promoting aberrant 3′ splice site usage; however, how this occurs mechanistically remains controversial.
Peiqi Xing +5 more
doaj +1 more source
MedComm – Future Medicine, Volume 5, Issue 3, September 2026.IDH mutation is an important event in hematological malignancies. This review systematically integrates the basic mechanism of IDH mutations and combines it with the clinical translation of related research progress. It also discusses the application strategies of IDH inhibitors and feasible research directions, with the aim of providing a theoretical ...
Jinkun Xu, Haiying Bai, Lijuan Hu
wiley +1 more source
A Technique for the Generation of Mucosal and Acral Melanoma Cell Lines
Pigment Cell &Melanoma Research, Volume 39, Issue 5, September 2026.Simplified steps to establish acral or mucosal melanoma cell lines. ABSTRACT Mucosal and acral melanomas are rare subtypes of melanoma with unique clinical and biological features. A dearth of well‐established and characterized melanoma cell lines that reflect rare subtypes impedes research on these lethal diseases.
Ishani Banik +17 more
wiley +1 more source
SF3B1: hotspot mutazionale nei prolattinomi [PDF]
L'Endocrinologo, 2021 Giovanna Mantovani, Federica Mangili
openaire +1 more source