Results 131 to 140 of about 10,998 (173)
U2 snRNP recognizes the branch site through a loaded-spring strand-invasion mechanism. [PDF]
Nucleic Acids ResPokorná P, Pena V, Magistrato A.
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Clonal haematopoiesis and risk of incident rheumatoid arthritis: results from the UK biobank. [PDF]
Clin Exp RheumatolCui J +9 more
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SF3B1 Mutations in Hematological Malignancies [PDF]
Cancers, 2022 Recently, mutations in the genes involved in the spliceosome have attracted considerable interest in different neoplasms. Among these, SF3B1 mutations have acquired great interest, especially in myelodysplastic syndromes, as they identify a subgroup of patients who can benefit from personalized therapy. The SF3B1 gene encodes the largest subunit of the
Daniela Cilloni +2 more
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SF3B1 facilitates HIF1-signaling and promotes malignancy in pancreatic cancer [PDF]
Cell Reports, 2022 Mutations in the splicing factor SF3B1 are frequently occurring in various cancers and drive tumor progression through the activation of cryptic splice sites in multiple genes. Recent studies also demonstrate a positive correlation between the expression
Gerald Schwank
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m6A-driven SF3B1 translation control steers splicing to direct genome integrity and leukemogenesis [PDF]
Molecular Cell, 2023 SF3B1 is the most mutated splicing factor (SF) in myelodysplastic syndromes (MDSs), which are clonal hematopoietic disorders with variable risk of leukemic transformation. Although tumorigenic SF3B1 mutations have been extensively characterized, the role
Maciej Ciesla +2 more
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U2AF65-Dependent SF3B1 Function in SMN Alternative Splicing [PDF]
Cells, 2020 Splicing factor 3b subunit 1 (SF3B1) is an essential protein in spliceosomes and mutated frequently in many cancers. While roles of SF3B1 in single intron splicing and roles of its cancer-linked mutant in aberrant splicing have been identified to some ...
Namjeong Choi, Jagyeong Oh, Jiyeon Ha
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Significance of SF3B1 Mutations in Myeloid Neoplasms
Clinics in Laboratory Medicine, 2023Myelodysplastic neoplasm with low blasts and SF3B1 mutation (MDS-LB-SF3B1) has undergone significant classification changes in the past year with the publication of the 5th edition of the World Health Organization Classification of Tumors of Haematopoietic and Lymphoid Tissues and the International Consensus Classification.
David C, Gajzer, Cecilia C S, Yeung
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Human Cancer-Associated Mutations of SF3B1 Lead to a Splicing Modification of Its Own RNA
Cancers, 2020 International audienceDeregulation of pre-mRNA splicing is observed in many cancers and hematological malignancies. Genes encoding splicing factors are frequently mutated in myelodysplastic syndromes, in which SF3B1 mutations are the most frequent. SF3B1
Eric Lippert +2 more
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