Results 141 to 150 of about 10,998 (173)

Uveal Melanomas with SF3B1 Mutations

Ophthalmology, 2016
Serdar Yavuzyigitoglu, Anna E Koopmans, Robert M Verdijk   +2 more
exaly   +2 more sources

Chronic myelomonocytic leukemia with ring sideroblasts/SF3B1 mutation presents with low monocyte count and resembles myelodysplastic syndromes with-RS/SF3B1 mutation in terms of phenotype and prognosis [PDF]

Frontiers in Oncology
IntroductionChronic myelomonocytic leukemia (CMML) and myelodysplastic syndromes (MDS) with ring sideroblasts (RS) or SF3B1 mutation (MDS-RS/SF3B1) differ in many clinical features, but share others, such as anemia.
Blanca Xicoy, Helena Pomares, Elisa Orna   +2 more
exaly   +2 more sources

Role Of Sf3b1 On Hematopoiesis

Blood, 2013
Abstract Frequent pathway mutation involving multiple components of the RNA splicing machinery is a cardinal feature of myeloid neoplasms showing myeloid dysplasia, in which the major mutational targets include U2AF35, ZRSR2, SRSF2 and SF3B1.
Manabu Matsunawa, Ryo Yamamoto, Masashi Sanada, Aiko Sato, Yusuke Shiozawa, Kenichi Yoshida, Yasunobu Nagata, Ayana Kon, Tetsuichi Yoshizato, Makoto Otsu, Kyoichi Isono, Haruhiko Koseki, Hiromitsu Nakauchi, Seishi Ogawa   +13 more
openaire   +1 more source

SF3B1in Chronic Lymphocytic Leukemia

New England Journal of Medicine, 2012
To the Editor: Wang et al. (Dec. 29 issue)1 report that SF3B1 mutation is associated with a shorter time to initiation of treatment in patients with chronic lymphocytic leukemia. However, this result should be interpreted with caution. In the discovery cohort of 91 patients, 29 were classified as having stage 0 disease, 43 as having stage I, and 19 as ...
Jinichi, Mori, Yukie, Takahashi, Tetsuya, Tanimoto   +2 more
openaire   +2 more sources

Impact of SF3B1 mutation on outcomes in myelofibrosis.

Journal of Clinical Oncology, 2022
e19080 Background: Splicing factor 3B subunit 1 ( SF3B1) mutations have been shown to confer a unique phenotype in MDS and MDS/MPN overlap syndromes, with ring sideroblasts, thrombocytosis and favorable prognosis. In myelofibrosis (MF) the frequency of SF3B1 mutation is <10% and may play a less important role in disease outcomes (Lasho et.
Prithviraj Bose, Jayastu Senapati, Lucia Masarova, Naveen Pemmaraju, Guillermo Montalban Bravo, Sherry Pierce, Lingsha Zhou, Guillermo Garcia-Manero, Hagop M. Kantarjian, Srdan Verstovsek   +9 more
openaire   +1 more source

The role of SF3B1 and NOTCH1 in the pathogenesis of leukemia

IUBMB Life, 2022
AbstractThe discovery of new genes/pathways improves our knowledge of cancer pathogenesis and presents novel potential therapeutic options. For instance, splicing factor 3b subunit 1 (SF3B1) and NOTCH1 genetic alterations have been identified at a high frequency in hematological malignancies, such as leukemia, and may be related to the prognosis of ...
Shiva Abolhasani, Seyyed Sina Hejazian, Vahid Karpisheh, Atefeh Khodakarami, Hamed Mohammadi, Jamshid Gholizadeh Navashenaq, Mohammad Hojjat‐Farsangi, Farhad Jadidi‐Niaragh   +7 more
openaire   +2 more sources

Chronic Lymphocytic Leukemia withSF3B1Mutation

New England Journal of Medicine, 2012
The authors found that chronic lymphocytic leukemia in patients with mutations in the SF3B1 RNA splicing gene has a more aggressive natural history than that in patients without such mutations.
Victor, Quesada, Andrew J, Ramsay, Carlos, Lopez-Otin   +2 more
openaire   +2 more sources

Abstract 4615: Influence of SF3B1 gene mutation is different from that of Sf3B1 inhibitor in colorectal cancer

Cancer Research, 2014
Abstract Purpose: We have reported that SF3B1 gene mutations are rare in colorectal cancer patients and SF3B1 gene mutations in codon 1074 are responsible for resistance to SF3B1 inhibitor (FR901464, FR) at the AACR annual meeting 2013. SF3B1 gene mutations in hematological malignancies are considered to be related to tumor progression ...
Tomoki Yamano, Shuji Kubo, Nagahide Matsubara, Aya Yano, Naohiro Tomita   +4 more
openaire   +1 more source

GPATCH8 modulates mutant SF3B1 mis-splicing and pathogenicity in hematologic malignancies

Molecular Cell
Mutations in the RNA splicing factor gene SF3B1 are common across hematologic and solid cancers and result in widespread alterations in splicing, yet there is currently no therapeutic means to correct this mis-splicing. Here, we utilize synthetic introns
Nina Fox, Zhuoning Li, Mara Monetti
exaly   +3 more sources

Cancer-associated SF3B1 mutations inhibit mRNA nuclear export by disrupting SF3B1–THOC5 interactions

The Journal of Biochemistry
Abstract Mutations in SF3B1 are common in many types of cancer, promoting cancer progression through aberrant RNA splicing. Recently, mRNA nuclear export has been reported to be defective in cells with the SF3B1 K700E mutation. However, the mechanism remains unclear.
Gang Liu, Bo Zhao, Yueru Shi, Youzhong Wan   +3 more
openaire   +2 more sources