Results 141 to 150 of about 12,272 (217)

Targeting TGFBR1 with the Investigational Inhibitor TP-6379 Improves Hematopoiesis in Low-Risk MDS Ex Vivo. [PDF]

Cells
Razabdouski T, Dalton R, Calescibetta A, Christiansen S, Ward G, Augello AC, Moon J, Yun S, Vincellette N, Wright G, Glode AJ, Chen DT, Kroeger J, Foulks JM, Warner SL, Duan B, Liu B, Wright KL, Eksioglu EA.   +18 more
europepmc   +1 more source

Acute Myeloid Leukemia with Myelodysplasia-Related Gene Mutations. [PDF]

J Clin Med
Testa U.
europepmc   +1 more source

Comprehensive analysis of prognostic factors in myelodysplastic syndromes with isolated deletion of chromosome 5q. [PDF]

Blood Adv
Montoro MJ, Navarro V, Acha P, Haferlach C, Chan O, Kubota Y, Schulz F, Briski R, Al Ali NH, Xicoy B, Lopez-Cadenas F, Bosch F, Romero AA, Meggendorfer M, Eder LN, Jerez A, Wang YH, Campagna A, Lanino L, Betz B, Santini V, Bernal T, Such E, Kubasch AS, Kewan T, Gurnari C, Zindel C, Kulasekararaj A, Voso MT, Sekeres M, Venugopal S, Varela ND, Al-Kali A, Platzbecker U, Haase D, Zeidan AM, Fenaux P, Diez-Campelo M, Garcia-Manero G, Wiseman DH, Della Porta MG, Germing U, Maciejewski J, Komrokji RS, Solé F, Haferlach T, Palomo L, Valcárcel D.   +47 more
europepmc   +1 more source

Structural basis of the regulation by CDK11 kinase of early spliceosome activation and evidence for its proofreading by DHX15 helicase. [PDF]

Nat Commun
Zhang Z, Kumar V, Panta S, Zhong J, Dybkov O, Dong H, Kastner B, Urlaub H, Stark H, Lührmann R.   +9 more
europepmc   +1 more source

SF3B1 mutation arises at the multipotent HSC level [PDF]

Blood, 2017
openaire   +2 more sources

CO36 | TGF-β pathway deregulation in SF3B1-mutated low risk myelodysplastic syndrome patients

Haematologica
Introduction. Myelodysplastic syndromes (MDS) associated with mutations in genes belonging to the splicing machinery, such as SF3B1, SRSF2, U2AF1 and ZRSR2, are characterized by inefficient hematopoiesis and variable risk of evolving into AML. Mutations
Eleonora Lumia
doaj  

High-diversity base mutagenesis via simultaneous adenine, cytosine and guanine editing. [PDF]

Nat Commun
Hong M, Luan C, Yuan M, Huang H, Guo X, Meng D, Huang M, Xu Y, Zhao S, Chen K, Chen J, Li D, Chen L.   +12 more
europepmc   +1 more source

Precursor RNA Properties Driving Cryptic 3’ Splice Site Selection in SF3B1 Mutant Malignancies

SF3B1 is a core component of the spliceosome involved in branch point recognition and 3’ splice site selection. SF3B1 is commonly mutated in myelodysplastic syndromes and other blood cancers with the K700E mutation being the most frequent.
Herbert, Austin A
core  

Proteomics-based approach reveals the involvement of spliceosomal components SF3B and SerpinB9 in dermatofibrosarcoma protuberans. [PDF]

Orphanet J Rare Dis
Xie Y, Li H, Liu T, Wang L, Yang M, Wan M, Huang J, Zhu Y.   +7 more
europepmc   +1 more source

Spliceosomal mutation drives melanoma tumorigenesis via lineage-specific RAS activation. [PDF]

Sci Adv
Jiang R, Xing P, Xie J, Bai G, Zhang Y, Hou P, Luo H, Ma Y, Liu R, Zheng Y, Chen X, Jiang B, Huang J, Zhang Y, Shain AH, Lei M, Judson-Torres RL, Ye J, Liu Z, Zeng H.   +19 more
europepmc   +1 more source