Results 121 to 130 of about 16,846 (200)

Splicing factor SF3B1 mutations and ring sideroblasts in myelodysplastic syndromes: a Brazilian cohort screening study

Revista Brasileira de Hematologia e Hemoterapia
Background: Myelodysplastic syndromes (MDS) comprise a group of malignant clonal hematologic disorders characterized by ineffective hematopoiesis and propensity for progression to acute myeloid leukemia.
Flávia Sacilotto Donaires, Felipe Martelli, Raquel de Melo Alves-Paiva, Silvia Maria Meira Magalhães, Ronald Feitosa Pinheiro, Rodrigo Tocantins Calado   +5 more
doaj   +1 more source

The expression and signalling patterns of CD180 toll like receptor in Chronic Lymphocytic Leukaemia (CLL) [PDF]

, 2019
Chronic lymphocytic leukaemia (CLL) is characterised by a progressive accumulation of mature CD5+CD20+CD23+ lymphocytes. Despite the remarkable progress in our understanding of the immunobiology of CLL, the aetiology of the disease remains unknown.
Sayed, U., Sayed, U.
core  

SF3B1 Gene [PDF]

, 2020
openaire   +1 more source

SF3B1: the lord of the rings in MDS [PDF]

Blood, 2020
Francesc Solé, Laura Palomo
openaire   +2 more sources

Determination of trunk neural crest cell fate and susceptibility to splicing perturbation by the DLC1-SF3B1-PHF5A splicing complex

Nature Communications
How the ubiquitously expressed splicing factors specifically regulate neural crest (NC) development and enhance their vulnerability to splicing perturbations remain poorly understood.
Zhengfan Zheng, Suisui Guo, Hoi Yau Tam, Jingkai Wang, Yanxia Rao, Man-Ning Hui, May Pui Lai Cheung, Alan Wai Lun Leung, Kelvin K. W. Wong, Rakesh Sharma, Jessica Aijia Liu, Martin Cheung   +11 more
doaj   +1 more source

SF3B1 Gene Mutation [PDF]

, 2020
openaire   +1 more source

SF3B1 thermostability as an assay for splicing inhibitor interactions

Journal of Biological Chemistry
The spliceosome protein, SF3B1 associates with U2 snRNP during early spliceosome assembly for pre-mRNA splicing. Frequent somatic mutations in SF3B1 observed in cancer necessitates characterization of its role in identifying the branchpoint adenosine of introns. Remarkably, SF3B1 is the target of three distinct natural product drugs, each identified by
Angela N. Amorello, Guddeti Chandrashekar Reddy, Bruno Melillo, Benjamin F. Cravatt, Arun K. Ghosh, Melissa S. Jurica   +5 more
openaire   +4 more sources

The splicing modulator sudemycin induces a specific antitumor response and cooperates with ibrutinib in chronic lymphocytic leukemia [PDF]

, 2015
Aymerich, Marta, Campo, Elías, Colomer, Dolors, Lagisetti, Chandraiah, López Guerra, Mónica, López Otín, Carlos, Montraveta, Arnau, Rodríguez, Vanina, Roldán, Jocabed, Rosich, Laia, Villamor Casas, Neus, Webb, Thomas R., Xargay-Torrent, Sçilvia   +12 more
core   +1 more source

SF3B1 wt Allele [PDF]

, 2020
openaire   +1 more source

P027 | Spalt-like transcription factor 4 deregulation in low risk myelodysplastic syndrome SF3B1-mutated patients

Haematologica
Introduction: Myelodysplastic syndromes (MDS) represent a heterogeneous group of clonal hematopoietic stem cell neoplasms characterized by ineffective hematopoiesis, peripheral cytopenias, and variable risk of progression to AML.
Eleonora Lumia
doaj