Results 151 to 160 of about 21,005 (271)

The Immunological Consequences of Clonal Hematopoiesis in Heart Failure

Immunological Reviews, Volume 337, Issue 1, January 2026.
ABSTRACT Inflammation is increasingly recognized as a central driver of heart failure (HF), particularly in older adults, yet the underlying immune mechanisms remain diverse and incompletely understood. Clonal hematopoiesis (CH), defined by the expansion of somatically mutated hematopoietic clones, has emerged as a risk factor for the development of ...
Megan A. Evans, Kenneth Walsh
wiley   +1 more source

Identification of two epitypes of IGHV unmutated chronic lymphocytic leukemia with distinct B‐cell‐related epigenetic imprinting and genetic alterations

HemaSphere, Volume 10, Issue 1, January 2026.
Stella Charalampopoulou, Silvia Ramos‐Campoy, Marti Duran‐Ferrer, Anna Puiggros, Joanna Kamaso, Florence Nguyen‐Khac, Gian Matteo Rigolin, Antonio Cuneo, Rosa Collado, Rocío García‐Serra, Claudia Haferlach, Margarita Ortega, Pau Abrisqueta, Francesc Bosch, Thorsten Zenz, María Laura Blanco, Rocío Salgado, Mª Dolores García‐Malo, Eva Gimeno, Armando Lopez‐Guillermo, Elias Campo, Laurence Etter, Jacqueline Schoumans, Blanca Espinet, Jose I. Martin‐Subero   +24 more
wiley   +1 more source

Subtractive hybridization identifies stem cell-associated genes in an acute myeloid leukemia with poor prognosis [PDF]

, 2016
Introduction: Current prognostic markers have improved survival prediction, however, it has not advanced treatment strategies. Gene expression profiling may identify biological markers suitable as therapeutic targets.
Abdullah, Maha, Cheong, Soon Keng, Lim, Jasmine, Ngiow, Shin Foong, Seow, Heng Fong   +4 more
core  

P735: THE ROLE OF SF3B1 MUTATIONS IN MYELODYSPLASTIC SYNDROMES

, 2022
Sandra Huber, Stephan Hütter, Manja Meggendorfer, Gregor Hoermann, Wencke Walter, Constance Baer, Wolfgang Kern, T. Haferlach, Claudia Haferlach   +8 more
openalex   +1 more source

MDS-associated SF3B1 mutations enhance proinflammatory gene expression in patient blast cells

, 2020
Daniel A. Pollyea, Hyun Min Kim, Brett M. Stevens, Frank Fang-Yao Lee, Chelsea Harris, Brenna R. Hedin, Jennifer R. Knapp, Brian P. O’Connor, Craig T. Jordan, Eric M. Pietras, Aik Choon Tan, Scott Alper   +11 more
openalex   +2 more sources

Malcovati L, Stevenson K, Papaemmanuil E, et al. SF3B1-mutant MDS as a distinct disease subtype: a proposal from the International Working Group for the Prognosis of MDS. Blood. 2020;136(2):157-170. [PDF]

, 2021

openalex   +1 more source

NEOPLASIAS MIELOIDES COM MUTAÇÃO SF3B1

Hematology, Transfusion and Cell Therapy, 2022
LR Fernandes, VRH Nunes, PEM Peonorio, LGF Cortes, SEA Rosa, CN Silveira, LB Lima, E Velloso, P Campregher   +8 more
openaire   +1 more source

Cancer-associated SF3B1 mutations affect alternative splicing by promoting alternative branchpoint usage

Nature Communications, 2016
Mutations in the splicing factor SF3B1 are found in uveal melanoma. Here, Alsafadi et al. use RNA-sequencing data from these cancers and experimental models, and show that mutant SF3B1 promotes alternative branchpoints in a specific gene subset and that ...
Samar Alsafadi, Alexandre Houy, Aude Battistella, Tatiana Popova, Michel Wassef, Emilie Henry, Franck Tirode, Angelos Constantinou, Sophie Piperno-Neumann, Sergio Roman-Roman, Martin Dutertre, Marc-Henri Stern   +11 more
doaj   +1 more source

Epidemiology and characteristics of validated mixed phenotype acute leukaemia—A comprehensive nationwide Danish cohort study

British Journal of Haematology, Volume 208, Issue 1, Page 353-357, January 2026.
Lisa‐Maj Christensen, Daniel Tuyet Kristensen, Karen Dybkær, Kirsten Grønbæk, Tarec Christoffer El‐Galaly, Marianne Schmidt Ettrup, Jonas Faartoft Jensen, Hans Beier Ommen, Anne Louise Tølbøll Sørensen, Dennis Lund Hansen, Rasmus Froberg Brøndum, Marianne Tang Severinsen   +11 more
wiley   +1 more source

Splicing factor SF3B1 mutations and ring sideroblasts in myelodysplastic syndromes: a Brazilian cohort screening study

Revista Brasileira de Hematologia e Hemoterapia
Background: Myelodysplastic syndromes (MDS) comprise a group of malignant clonal hematologic disorders characterized by ineffective hematopoiesis and propensity for progression to acute myeloid leukemia.
Flávia Sacilotto Donaires, Felipe Martelli, Raquel de Melo Alves-Paiva, Silvia Maria Meira Magalhães, Ronald Feitosa Pinheiro, Rodrigo Tocantins Calado   +5 more
doaj   +1 more source