Results 31 to 40 of about 16,846 (200)

Biology of advanced uveal melanoma and next steps for clinical therapeutics [PDF]

, 2014
Uveal melanoma is the most common intraocular malignancy although it is a rare subset of all melanomas. Uveal melanoma has distinct biology relative to cutaneous melanoma, with widely divergent patient outcomes.
Bastian, BC, Bowcock, AM, Carvajal, RD, Flaherty, KT, Gershenwald, JE, Gutkind, JS, Luke, JJ, McKenna, KC, Patel, PM, Sato, T, Selig, S, Sossman, JA, Streicher, HZ, Sznol, M, Thurin, M, Triozzi, PL, Van Meir, EG, Welch, J   +17 more
core   +1 more source

Biallelic BIRC3 inactivation in chronic lymphocytic leukaemia patients with 11q deletion identifies a subgroup with very aggressive disease. [PDF]

, 2018
Not ...
Bomben, R, Bonina, S, Cafforio, L, Cappelli, Lv, Cuneo, A, Dal Bo, M, Del Giudice, I, Del Poeta, G, Diop, F, Favini, C, Foá, R., Gaidano, G, Gattei, V, Guarini, A, Ilari, C, Mariglia, P, Marinelli, M, Mauro, Fr, Messina, M, Peragine, N, Piciocchi, A, Raponi, S, Rigolin, Gm, Rossi, D, Rossi, F   +24 more
core   +1 more source

Co-targeting HGF/cMET Signaling with MEK Inhibitors in Metastatic Uveal Melanoma. [PDF]

, 2017
Patients with metastatic uveal melanoma usually die within 1 year of diagnosis, emphasizing an urgent need to develop new treatment strategies. The liver is the most common site of metastasis.
Aplin, Andrew E., Cheng, Hanyin, Chua, Vivian, Davies, Michael A., Kageyama, Ken, Liao, Connie, Purwin, Timothy J., Sato, Takami, Terai, Mizue   +8 more
core   +2 more sources

Rare SF3B1 R625 mutations in cutaneous melanoma [PDF]

Melanoma Research, 2014
RNA splicing is the cellular process that has only recently been found to be an important target for various cancers. Among the spliceosome genes that are involved in cancers, SF3B1 is most frequently mutated. Recurrent mutation in codon 625 has been found in uveal melanoma, but this mutation has not been identified in cutaneous melanoma. We used whole-
Yong, Kong, Michael, Krauthammer, Ruth, Halaban   +2 more
openaire   +2 more sources

Studying the connection between SF3B1 and four types of cancer by analyzing networks constructed based on published research

Scientific Reports, 2023
Splicing factor 3B subunit 1 (SF3B1) is the largest component of SF3b protein complex which is involved in the pre-mRNA splicing mechanism. Somatic mutations of SF3B1 were shown to be associated with aberrant splicing, producing abnormal transcripts that
Asmaa Samy, Mehmet Kemal Ozdemir, Reda Alhajj   +2 more
doaj   +1 more source

The splicing factor Sf3b1 regulates erythroid maturation and proliferation via TGFβ signaling in zebrafish

Blood Advances, 2019
: The spliceosomal component Splicing Factor 3B, subunit 1 (SF3B1) is one of the most prevalently mutated factors in the bone marrow failure disorder myelodysplastic syndrome.
Adriana De La Garza, Rosannah C. Cameron, Varun Gupta, Ellen Fraint, Sara Nik, Teresa V. Bowman   +5 more
doaj   +1 more source

SF3B1 is a stress-sensitive splicing factor that regulates both HSF1 concentration and activity. [PDF]

PLoS ONE, 2017
The heat shock response (HSR) is a well-conserved, cytoprotective stress response that activates the HSF1 transcription factor. During severe stress, cells inhibit mRNA splicing which also serves a cytoprotective function via inhibition of gene ...
Karen S Kim Guisbert, Eric Guisbert
doaj   +1 more source

Lack of SF3B1 R625 mutations in cutaneous melanoma [PDF]

Diagnostic Pathology, 2013
Abstract Background Melanoma is a deadly disease affecting people worldwide. Genetic studies have identified different melanoma subtypes characterized by specific recurrently mutated genes and led to the successful clinical introduction of targeted therapies.
Schilling, Bastian, Bielefeld, Nicola, Sucker, Antje, Hillen, Uwe, Zimmer, Lisa, Schadendorf, Dirk, Zeschnigk, Michael, Griewank, Klaus   +7 more
openaire   +2 more sources

HIF-driven SF3B1 induces KHK-C to enforce fructolysis and heart disease. [PDF]

, 2015
Fructose is a major component of dietary sugar and its overconsumption exacerbates key pathological features of metabolic syndrome. The central fructose-metabolising enzyme is ketohexokinase (KHK), which exists in two isoforms: KHK-A and KHK-C, generated
A Casonato, A Corrionero, A Hirschy, A Troilo, A Ventura, Alexandre Sarre, Ana Vukolic, AR Grosso, C Wang, CA Lewis, CJ David, CP Diggle, CP Diggle, Cédric Cortijo, Fiona Grimm, GL Semenza, GW Yip, H Dolatshad, H Kuroda, I Falcão-Pires, I Shiojima, J Fukuzawa, J Krishnan, J Krishnan, J König, J Rappsilber, JA Haefliger, JA Hill, Jaya Krishnan, Jernej Ule, JM Buescher, K-Y Kim, L van Heerebeek, LE Huang, M Fang, M Nemir, M Shiota, Manuel Hörl, Melis Kayikci, MG Vander Heiden, MG Vander Heiden, N-H Son, Nicola Zamboni, Niklaus Fankhauser, NL Barbosa-Morais, NS Radin, Owen Feehan, P Cirillo, Peter Mirtschink, R Koopman, R Ramasamy, S Bonnal, S Sharma, Samuel Sossalla, Sebastian N. Stehr, T Fuhrer, T Ishimoto, T Kawasaki, Thierry Pedrazzini, W Luo, WG Kaelin, Wilhelm Krek, Y Gao, Yann Christinat, Z Kassiri   +64 more
core   +2 more sources

The genomic landscape of chronic lymphocytic leukemia: clinical implications [PDF]

, 2013
A precise understanding of the genomic and epigenomic features of chronic lymphocytic leukemia (CLL) may benefit the study of the disease’s staging and treatment.
Campo, Elías, López Otín, Carlos, Quesada Fernández, Víctor, Ramsay, Andrew John, Rodríguez Martínez, David, Suárez Puente, Xosé Antón   +5 more
core   +2 more sources