Results 41 to 50 of about 21,005 (271)

Altered DNA Methylation Profiles in SF3B1 Mutated CLL Patients [PDF]

International Journal of Molecular Sciences, 2021
Mutations in splicing factor genes have a severe impact on the survival of cancer patients. Splicing factor 3b subunit 1 (SF3B1) is one of the most frequently mutated genes in chronic lymphocytic leukemia (CLL); patients carrying these mutations have a poor prognosis.
Alicja Pacholewska, Christina Grimm, Carmen D. Herling, Matthias Lienhard, Anja Königs, Bernd Timmermann, Janine Altmüller, Oliver Mücke, Hans Christian Reinhardt, Christoph Plass, Ralf Herwig, Michael Hallek, Michal R. Schweiger   +12 more
openaire   +5 more sources

A Rare Case of Plasma Cell Myeloma, Myelodysplastic Neoplasm with Low Blast and SF3B1 Mutation and Dyserythropoiesis with Ring Sideroblasts [PDF]

Journal of Liaquat National Hospital
Myelodysplastic syndromes (MDS) are heterogeneous hematological neoplasms which lead to dysplasia, cytopenia and hematopoiesis. They have a risk of transforming into Acute Myeloid Leukemia (AML) in some cases.
Shamail Zia, Brenda Ly, Alma Sanchez Salazar, Bridget Herschap, Aamir Ehsan   +4 more
doaj   +1 more source

SF3B1 mutation in pancreatic cancer contributes to aerobic glycolysis and tumor growth through a PP2A–c‐Myc axis

Molecular Oncology, 2021
Hot spot gene mutations in splicing factor 3b subunit 1 (SF3B1) are observed in many types of cancer and create abundant aberrant mRNA splicing, which is profoundly implicated in tumorigenesis.
Jian‐Yu Yang, Yan‐Miao Huo, Min‐Wei Yang, Yang Shen, De‐Jun Liu, Xue‐Liang Fu, Ling‐Ye Tao, Rui‐Zhe He, Jun‐Feng Zhang, Rong Hua, Shu‐Heng Jiang, Yong‐Wei Sun, Wei Liu   +12 more
doaj   +1 more source

Acquired Elliptocytosis as a Manifestation of Myelodysplastic Syndrome with Ring Sideroblasts and Multilineage Dysplasia. [PDF]

, 2017
Acquired elliptocytosis is a known but rarely described abnormality in the myelodysplastic syndromes (MDS). Here we report the case of an elderly male who was admitted to the hospital with chest pain, dyspnea, and fatigue and was found to be anemic with ...
Dwyre, Denis M, Jonas, Brian A, Kjelland, Jacob D   +2 more
core   +2 more sources

SF3B1 deficiency impairs human erythropoiesis via activation of p53 pathway: implications for understanding of ineffective erythropoiesis in MDS

Journal of Hematology & Oncology, 2018
Background SF3B1 is a core component of splicing machinery. Mutations in SF3B1 are frequently found in myelodysplastic syndromes (MDS), particularly in patients with refractory anemia with ringed sideroblasts (RARS), characterized by isolated anemia ...
Yumin Huang, John Hale, Yaomei Wang, Wei Li, Shijie Zhang, Jieying Zhang, Huizhi Zhao, Xinhua Guo, Jing Liu, Hongxia Yan, Karina Yazdanbakhsh, Gang Huang, Christopher D. Hillyer, Narla Mohandas, Lixiang Chen, Ling Sun, Xiuli An   +16 more
doaj   +1 more source

The SF3B1 R625H mutation promotes prolactinoma tumor progression through aberrant splicing of DLG1

Journal of Experimental & Clinical Cancer Research, 2022
Background Recently, a hotspot mutation in prolactinoma was observed in splicing factor 3b subunit 1 (SF3B1 R625H ), but its functional effects and underlying molecular mechanisms remain largely unexplored.
Jing Guo, Chuzhong Li, Qiuyue Fang, Yulou Liu, Dawei Wang, Yiyuan Chen, Weiyan Xie, Yazhuo Zhang   +7 more
doaj   +1 more source

Co-targeting HGF/cMET Signaling with MEK Inhibitors in Metastatic Uveal Melanoma. [PDF]

, 2017
Patients with metastatic uveal melanoma usually die within 1 year of diagnosis, emphasizing an urgent need to develop new treatment strategies. The liver is the most common site of metastasis.
Aplin, Andrew E., Cheng, Hanyin, Chua, Vivian, Davies, Michael A., Kageyama, Ken, Liao, Connie, Purwin, Timothy J., Sato, Takami, Terai, Mizue   +8 more
core   +2 more sources

Monolobated megakaryocytes and ring sideroblasts: A morphological prelude to multihit TP53 and complex karyotype. [PDF]

Br J Haematol
British Journal of Haematology, Volume 208, Issue 1, Page 11-12, January 2026.
Marco-Ayala J, Chen T, Ortuño FJ, Lozano ML.   +3 more
europepmc   +2 more sources

Biallelic BIRC3 inactivation in chronic lymphocytic leukaemia patients with 11q deletion identifies a subgroup with very aggressive disease. [PDF]

, 2018
Not ...
Bomben, R, Bonina, S, Cafforio, L, Cappelli, Lv, Cuneo, A, Dal Bo, M, Del Giudice, I, Del Poeta, G, Diop, F, Favini, C, Foá, R., Gaidano, G, Gattei, V, Guarini, A, Ilari, C, Mariglia, P, Marinelli, M, Mauro, Fr, Messina, M, Peragine, N, Piciocchi, A, Raponi, S, Rigolin, Gm, Rossi, D, Rossi, F   +24 more
core   +1 more source

Studying the connection between SF3B1 and four types of cancer by analyzing networks constructed based on published research

Scientific Reports, 2023
Splicing factor 3B subunit 1 (SF3B1) is the largest component of SF3b protein complex which is involved in the pre-mRNA splicing mechanism. Somatic mutations of SF3B1 were shown to be associated with aberrant splicing, producing abnormal transcripts that
Asmaa Samy, Mehmet Kemal Ozdemir, Reda Alhajj   +2 more
doaj   +1 more source