Results 41 to 50 of about 16,846 (200)

Transcriptome sequencing reveals potential mechanism of cryptic 3' splice site selection in SF3B1-mutated cancers. [PDF]

PLoS Computational Biology, 2015
Mutations in the splicing factor SF3B1 are found in several cancer types and have been associated with various splicing defects. Using transcriptome sequencing data from chronic lymphocytic leukemia, breast cancer and uveal melanoma tumor samples, we ...
Christopher DeBoever, Emanuela M Ghia, Peter J Shepard, Laura Rassenti, Christian L Barrett, Kristen Jepsen, Catriona H M Jamieson, Dennis Carson, Thomas J Kipps, Kelly A Frazer   +9 more
doaj   +1 more source

Inhibition of SF3b1 by pladienolide B evokes cycle arrest, apoptosis induction and p73 splicing in human cervical carcinoma cells

Artificial Cells, Nanomedicine, and Biotechnology, 2019
Pladienolide B is a potent cancer cell growth inhibitor that targets the SF3b1 subunit of the spliceosome. There is considerable interest in the compound as a tool to study SF3b1 function in cancer.
Qianjing Zhang, Cuixia Di, Junfang Yan, Fang Wang, Tao Qu, Yupei Wang, Yuhong Chen, Xuetian Zhang, Yang Liu, Hongying Yang, Hong Zhang   +10 more
doaj   +1 more source

A Low Frequency of Losses in 11q Chromosome Is Associated with Better Outcome and Lower Rate of Genomic Mutations in Patients with Chronic Lymphocytic Leukemia [PDF]

, 2015
This work was supported by grants from the Spanish Fondo de Investigaciones Sanitarias FIS09/01543, PI12/00281 and PI15/01471, Instituto de Salud Carlos III (ISCIII), European Regional Development Fund (ERDF) "Una manera de hacer Europa", Proyectos de ...
Hernández Sánchez, María, Hernández, José Ángel, Luño Fernández, Elisa, Rodríguez Vicente, Ana Eugenia   +3 more
core   +2 more sources

Low rate of calreticulin mutations in refractory anaemia with ring sideroblasts and marked thrombocytosis [PDF]

, 2014
Broséus, J., Lippert, E., Harutyunyan, A.S., Jeromin, S., Zipperer, E., Florensa, L., Milosevic, J.D., Haferlach, T., Germing, U., Luño, E., Schnittger, S., Kralovics, R., Girodon ...
Broséus, Julien, Harutyunyan, S., Jeromin, S., Lippert, A. S., Luño Fernández, Elisa   +4 more
core   +1 more source

Expression of circular RNAs in myelodysplastic neoplasms and their association with mutations in the splicing factor gene SF3B1

Molecular Oncology, 2023
Mutations in the splicing factor 3b subunit 1 (SF3B1) gene are frequent in myelodysplastic neoplasms (MDS). Because the splicing process is involved in the production of circular RNAs (circRNAs), we investigated the impact of SF3B1 mutations on circRNA ...
Iva Trsova, Andrea Hrustincova, Zdenek Krejcik, David Kundrat, Aleš Holoubek, Karolina Staflova, Lucie Janstova, Sarka Vanikova, Katarina Szikszai, Jiri Klema, Petr Rysavy, Monika Belickova, Monika Kaisrlikova, Jitka Vesela, Jaroslav Cermak, Anna Jonasova, Jiri Dostal, Jan Fric, Jan Musil, Michaela Dostalova Merkerova   +19 more
doaj   +1 more source

Age, JAK2V617F and SF3B1 mutations are the main predicting factors for survival in refractory anaemia with ring sideroblasts and marked thrombocytosis [PDF]

, 2013
Broséus, J., Alpermann, T., Wulfert, M., Florensa Brichs, L., Jeromin, S., Lippert, E., Rozman, M., Lifermann, F., Grossmann, V., Haferlach, T., Germing, U., Luño, E., Girodon, F., Schnittger ...
Alpermann, T., Brichs, L. F., Broséus, Julien, Grossmann, V., Jeromin, S., Lifermann, F., Lippert, E., Luño Fernández, Elisa, Rozman, M., Wulfert, M.   +9 more
core   +1 more source

SomaticSF3B1Mutation in Myelodysplasia with Ring Sideroblasts [PDF]

New England Journal of Medicine, 2011
Myelodysplastic syndromes are a diverse and common group of chronic hematologic cancers. The identification of new genetic lesions could facilitate new diagnostic and therapeutic strategies.We used massively parallel sequencing technology to identify somatically acquired point mutations across all protein-coding exons in the genome in 9 patients with ...
Papaemmanuil, E, Cazzola, M, Boultwood, J, Malcovati, L, Vyas, P, Bowen, D, Pellagatti, A, Wainscoat, JS, Hellstrom Lindberg, E, GAMBACORTI PASSERINI, CARLO, Godfrey, AL, Rapado, I, Cvejic, A, Rance, R, McGee, C, Ellis, P, Mudie, LJ, Stephens, PJ, McLaren, S, Massie, CE, Tarpey, PS, Varela, I, Nik Zainal, S, Davies, HR, Shlien, A, Jones, D, Raine, K, Hinton, J, Butler, AP, Teague, JW, Baxter, EJ, Score, J, Galli, A, Della Porta, MG, Travaglino, E, Groves, M, Tauro, S, Munshi, NC, Anderson, KC, El Naggar, A, Fischer, A, Mustonen, V, Warren, AJ, Cross, NC, Green, AR, Futreal, PA, Stratton, MR, Campbell, PJ, Chronic Myeloid Disorders Working Group of the International Cancer Genome Consortium   +48 more
openaire   +4 more sources

Inhibition of SF3B1 improves the immune microenvironment through pyroptosis and synergizes with αPDL1 in ovarian cancer

Cell Death and Disease, 2023
Ovarian cancer is resistant to immune checkpoint blockade (ICB) treatment. Combination of targeted therapy and immunotherapy is a promising strategy for ovarian cancer treatment benefit from an improved immune microenvironment.
Shourong Wang, Yao Liu, Huimin Xiao, Zhongshao Chen, Xiaohang Yang, Jingjing Yin, Yingwei Li, Cunzhong Yuan, Shi Yan, Gang Chen, Qinglei Gao, Beihua Kong, Chaoyang Sun, Kun Song   +13 more
doaj   +1 more source

Copy-number and gene dependency analysis reveals partial copy loss of wild-type SF3B1 as a novel cancer vulnerability

eLife, 2017
Genomic instability is a hallmark of human cancer, and results in widespread somatic copy number alterations. We used a genome-scale shRNA viability screen in human cancer cell lines to systematically identify genes that are essential in the context of ...
Brenton R Paolella, William J Gibson, Laura M Urbanski, John A Alberta, Travis I Zack, Pratiti Bandopadhayay, Caitlin A Nichols, Pankaj K Agarwalla, Meredith S Brown, Rebecca Lamothe, Yong Yu, Peter S Choi, Esther A Obeng, Dirk Heckl, Guo Wei, Belinda Wang, Aviad Tsherniak, Francisca Vazquez, Barbara A Weir, David E Root, Glenn S Cowley, Sara J Buhrlage, Charles D Stiles, Benjamin L Ebert, William C Hahn, Robin Reed, Rameen Beroukhim   +26 more
doaj   +1 more source

Splicing-factor alterations in cancers [PDF]

, 2016
Tumor-associated alterations in RNA splicing result either from mutations in splicing-regulatory elements or changes in components of the splicing machinery.
Anczukow, O., Krainer, A. R.
core   +1 more source