Results 71 to 80 of about 16,846 (200)

Modeling SF3B1 Mutations in Cancer: Advances, Challenges, and Opportunities [PDF]

Cancer Cell, 2016
In this issue of Cancer Cell, Obeng et al. identify the consequences of expressing the most common mutation in the spliceosomal gene SF3B1 on hematopoiesis. The knockin mouse model described represents a valuable tool to dissect the effects of SF3B1 mutations on transformation, splicing, and less well-characterized functions of SF3B1.
Daichi, Inoue, Omar, Abdel-Wahab
openaire   +2 more sources

Optical genome mapping detects cryptic high‐risk and targetable abnormalities in adult AML

British Journal of Haematology, EarlyView.
Summary Acute myeloid leukaemia (AML) risk stratification relies on cytogenetic and molecular abnormalities defined by European LeukemiaNet (ELN) 2022. Conventional cytogenetic techniques, including chromosomal banding analysis (CBA) and fluorescence in situ hybridization, have limited resolution and may miss cryptic events. Optical genome mapping (OGM)
Audrey Bidet, Elodie Laharanne, Manon Dos Santos, Anne‐Charlotte De Grande, Thibaut Leguay, Arnaud Pigneux, Eric Frison, Sandrine Achard, Stéphanie Dupont‐Moufakkir, Emilie Klein, Pierre‐Yves Dumas   +10 more
wiley   +1 more source

A highly abundant circular RNA from the RMST locus plays a role in posterior fossa ependymoma pathogenesis

Brain Pathology, EarlyView.
circRMST (hsa_circ_0099634) is by far the most abundant isoform from the RMST locus. It is highly expressed in cancer cells throughout ependymoma patient samples and is located in the cytoplasm. circRMST knockdown causes cell cycle arrest and induces differentiation, and it is a marker for poor prognosis. The figure is made using BioRender.
Ulvi Ahmadov, Charlotte W. Udengaard, Stine M. Vissing, Silke D. Nielsen, Kim‐Gwendolyn Dietrich, Benedicte Parm Ulhøi, Lasse S. Kristensen   +6 more
wiley   +1 more source

Expression levels of SF3B3 correlate with prognosis and endocrine resistance in estrogen receptor-positive breast cancer [PDF]

, 2015
De novo or acquired resistance to endocrine therapy limits its utility in a significant number of estrogen receptor-positive (ER-positive) breast cancers.
Badve, Sunil, Goswami, Chirayu P., Gu, Xiaoping, Gökmen-Polar, Yesim, Janga, Sarath Chandra, Nallamothu, Gouthami, Neelamraju, Yaseswini   +6 more
core   +1 more source

Early‐Onset Digestive System Cancers: Risk Factors and Clinicopathological and Molecular Features Across Organ Sites

Cancer Science, EarlyView.
Shared risk factors, clinical features, and tumor characteristics across multiple early‐onset cancer types are shown in this Graphical Abstract. Integrative approaches combining molecular pathology, oncology, and population sciences offer opportunities to clarify underlying mechanisms and help us develop preventive strategies for early‐onset cancers ...
Nobuhiro Nakazawa, Satoko Ugai, Atsushi Kondo, Kosuke Matsuda, Shu Kato, Genki Usui, Shiori Tanaka, Hwa‐Young Lee, Xinyuan Zhang, Hideo Miyagawa, Mai Chan Lau, Hiroshi Saeki, Yukihide Kanemitsu, Andrew T. Chan, Shuji Ogino, Minkyo Song, Juha P. Väyrynen, Tomotaka Ugai   +17 more
wiley   +1 more source

Significance of Myelodysplasia‐Related Mutations and the Genetic Landscape of Acute Leukemias of Ambiguous Lineage

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT The recent fifth edition WHO classification and ICC classification systems have moved further toward genetically defined classifications of acute leukemias. Both now recognize myelodysplasia‐related (MR) mutations as defining of MDS‐related AML (AML‐MR).
Timothy J. Kirtek, Olga K. Weinberg
wiley   +1 more source

The SF3B1 inhibitor spliceostatin A (SSA) elicits apoptosis in chronic lymphocytic leukemia cells through downregulation of Mcl-1

, 2015
The pro-survival Bcl-2 family member Mcl-1 is expressed in chronic lymphocytic leukemia (CLL), with high expression correlated with progressive disease.
Blakemore, S.J., Blunt, M.D., Cragg, M.S., Dobson, R.C., Duncombe, A., Forconi, F., Koide, K., Larrayoz, M., Oscier, D., Packham, G., Rose-Zerilli, M.J.J., Steele, A.J., Strefford, J.C., Walewska, R., Yoshida, M.   +14 more
core   +1 more source

Jerantinine A induces tumor-specific cell death through modulation of splicing factor 3b subunit 1 (SF3B1) [PDF]

, 2017
Precursor mRNA (pre-mRNA) splicing is catalyzed by a large ribonucleoprotein complex known as the spliceosome. Numerous studies have indicated that aberrant splicing patterns or mutations in spliceosome components, including the splicing factor 3b ...
Bradshaw, Tracey D., Chung, Felicia Fei-Lei, Hii, Ling-Wei, Kam, Toh-Seok, Leong, Chee-Onn, Lim, Kuan-Hon, Mai, Chun Wai, Raja, Vijay Joseph, See, Sze-Jia, Tan, Boon-Shing, Tan, Perry Faith Tze Ming, Tan, Si Hoey, Tan, Yuen-Fen, Wong, Li-Zhe, Yam, Wai Keat   +14 more
core   +1 more source

SF3B1 and the riddle of the ring sideroblast [PDF]

Blood, 2012
In this issue of Blood , Visconte and colleagues report on their investigations into the pathophysiologic effects of altered SF3B1 in patients with myelodysplastic syndromes (MDS).[1][1] A crucial component of the spliceosomal U2snRNP complex, SF3B1 participates in normal RNA splicing.
openaire   +2 more sources

Subclonal evolution involving SF3B1 mutations in chronic lymphocytic leukemia [PDF]

Leukemia, 2013
Mutations in genes encoding the spliceosome machinery recently have been described in hematological malignancies,1, 2 particularly in myelodysplastic syndrome (MDS) and chronic lymphocytic leukemia (CLL). These mutations can occur in genes encoding different components of the spliceosome.3 However, the most frequent of such mutations observed in CLL ...
Schwaederlé, M, Ghia, E, Rassenti, L Z, Obara, M, Dell' Aquila, M L, Fecteau, J F, Kipps, T J   +6 more
openaire   +2 more sources