Results 81 to 90 of about 16,846 (200)

Common Hematologic Emergencies—Acute Promyelocytic Leukemia and Microangiopathic Hemolytic Anemias—A Pivotal Role of Clinical Laboratory

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Hematologic emergencies are urgent health conditions which result in significant mortality and morbidity unless timely therapeutic measures are taken. Therapeutic success depends on their timely and accurate recognition by hematology laboratory services.
Ganna Shestakova, Nicolas Ulrich Edgar, Anton V. Rets   +2 more
wiley   +1 more source

Rewards of divergence in sequences, 3-D structures and dynamics of yeast and human spliceosome SF3b complexes

Current Research in Structural Biology, 2021
The evolution of homologous and functionally equivalent multiprotein assemblies is intriguing considering sequence divergence of constituent proteins.
Arangasamy Yazhini, Sankaran Sandhya, Narayanaswamy Srinivasan   +2 more
doaj   +1 more source

Improvements in Real‐World Survival in the Setting of a Recent Paradigm Shift in Acute Myeloid Leukemia Treatment

European Journal of Haematology, Volume 116, Issue 4, Page 416-424, April 2026.
ABSTRACT Therapeutic options for newly diagnosed (ND) acute myeloid leukemia (AML) have increased in recent years, leading to a shift in the treatment paradigm from conventional, intensive chemotherapy toward targeted and less intensive therapy. Since 2017, there has been a surge in FDA approvals for novel therapies, including small molecule inhibitors
Thuy N. Ho, Patrick Willard, Graeme F. Murray, Li Liu, Nolan Wages, Hyun Lee, Keri R. Maher   +6 more
wiley   +1 more source

SF3B1-mutated chronic lymphocytic leukemia shows evidence of NOTCH1 pathway activation including CD20 downregulation

Haematologica, 2020
Chronic lymphocytic leukemia (CLL) is characterized by low CD20 expression, in part explained by an epigenetic-driven downregulation triggered by mutations of the NOTCH1 gene.
Federico Pozzo, Tamara Bittolo, Erika Tissino, Filippo Vit, Elena Vendramini, Luca Laurenti, Giovanni D’Arena, Jacopo Olivieri, Gabriele Pozzato, Francesco Zaja, Annalisa Chiarenza, Francesco Di Raimondo, Antonella Zucchetto, Riccardo Bomben, Francesca Maria Rossi, Giovanni Del Poeta, Michele Dal Bo, Valter Gattei   +17 more
doaj   +1 more source

Antitumor activity of splicing inhibitor pladienolide B in erythroleukemia: a study in cell lines [PDF]

, 2015
Trabalho final de mestrado integrado em Medicina (Hematologia/Biologia Molecular), apresentado à Faculdade de Medicina da Universidade de Coimbra.The splicing of pre-mRNA into functional mRNA, carried out by the spliceosome, represents a crucial step ...
Petronilho, Sara Lopes
core  

Metastatic disease in polyploid uveal melanoma patients is associated with BAP1 mutations [PDF]

, 2016
PURPOSE. Most of the uvea melanoma (UM) display a near-diploid (normal, ~2N) karyotype with only a few chromosomal changes. In contrast to these simple aberrations 18% of the UM samples show a polyploid character (>2N) and this was associated with an ...
Beverloo, H.B. (Berna), Brüggenwirth, H.T. (Hennie), Dubbink, H.J. (Erik Jan), Kiliç, E. (Emine), Klein, A. (Annelies) de, Marion, R. (Ronald) van, Mensink, H.W. (Hanneke), Naus, N.C. (Nicole), Paridaens, A.D.A. (Dion), Smit, K.N. (Kyra), Vaarwater, J. (Jolanda), Verdijk, R.M. (Robert), Yavuzyigitoglu, S. (Serdar)   +12 more
core   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, Volume 20, Issue 3, Page 804-822, March 2026.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

SF3B1 and BAP1 mutations in blue nevus-like melanoma [PDF]

Modern Pathology, 2017
Blue nevi are melanocytic tumors originating in the cutaneous dermis. Malignant tumors may arise in association with or resembling blue nevi, so called 'blue nevus-like melanoma', which can metastasize and result in patient death. Identifying which tumors will behave in a clinically aggressive manner can be challenging.
Griewank, Klaus, Müller, Hansgeorg, Jackett, Louise A., Emberger, Michael, Möller, Inga, van de Nes, Johannes, Zimmer, Lisa, Livingstone, Elisabeth, Wiesner, Thomas, Scholz, Simone L., Cosgarea, Ioana, Sucker, Antje, Schimming, Tobias, Hillen, Uwe, Schilling, Bastian, Paschen, Annette, Reis, Henning, Mentzel, Thomas, Kutzner, Heinz, Rütten, Arno, Murali, Rajmohan, Scolyer, Richard A., Schadendorf, Dirk   +22 more
openaire   +2 more sources

Prognostic impact of SF3B1 mutation and multilineage dysplasia in myelodysplastic syndromes with ring sideroblasts: a Mayo Clinic study of 170 informative cases

Haematologica
The revised 4th edition of the World Health Organization (WHO4R) classification lists myelodysplastic syndromes with ring sideroblasts (MDS-RS) as a separate entity with single lineage (MDS-RS-SLD) or multilineage (MDS-RS-MLD) dysplasia. The more recent
Faiqa Farrukh, Maymona Abdelmagid, Abhishek Mangaonkar, Mrinal Patnaik, Aref Al-Kali, Michelle A. Elliott, Kebede H. Begna, Christopher C. Hook, William J. Hogan, Animesh Pardanani, Mark R. Litzow, Rhett P. Ketterling, Naseema Gangat, Daniel A. Arber, Attilio Orazi, Rong He, Kaaren Reichard, Ayalew Tefferi   +17 more
doaj   +1 more source

Comparing Nonparametric Bayesian Tree Priors for Clonal Reconstruction of Tumors

, 2014
Statistical machine learning methods, especially nonparametric Bayesian methods, have become increasingly popular to infer clonal population structure of tumors.
Deshwar, Amit G., Morris, Quaid, Vembu, Shankar   +2 more
core   +1 more source