Results 81 to 90 of about 641 (96)

Y-box binding proteins in immunity and RNA virus infection. [PDF]

Microbiol Mol Biol Rev
Strilets T, Garcia-Blanco MA.
europepmc   +1 more source

The making of a dangerous vector: factors shaping the vector competence of <i>Aedes</i> mosquitoes. [PDF]

Front Cell Infect Microbiol
Wu Y, Wu J, Wu Q, Cai H, Hu J, Lin Z, Liao R.   +6 more
europepmc   +1 more source

Host-virus molecular arms race: RNAi-mediated antiviral defense and viral suppressor of RNAi. [PDF]

Cell Insight
Zhang B, Zhou X, Ren Y.
europepmc   +1 more source

The Structural Basis of Pathogenic Subgenomic Flavivirus RNA (sfRNA) Production [PDF]

Science, 2014
Resisting the Chop Dengue, West Nile, and Yellow Fever viruses are all flaviviruses that have single-stranded RNA genomes and form specific, short flaviviral RNAs (sfRNAs) during infection that cause viral pathogenicity. These sfRNAs are produced by the incomplete degradation of viral RNA by the host-cell exonuclease Xrn1.
David A Costantino, Jeffrey Wilusz, Jeffrey S Kieft   +2 more
exaly   +3 more sources

Flavivirus sfRNA suppresses antiviral RNA interference in cultured cells and mosquitoes and directly interacts with the RNAi machinery

Virology, 2015
Productive arbovirus infections require mechanisms to suppress or circumvent the cellular RNA interference (RNAi) pathway, a major antiviral response in mosquitoes. In this study, we demonstrate that two flaviviruses, Dengue virus and Kunjin virus, significantly repress siRNA-mediated RNAi in infected human cells as well as during infection of the ...
Jeffrey Wilusz, Carol J Wilusz, Gregory D Ebel   +2 more
exaly   +3 more sources

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Promoter-like activity on the minus strand supports sfRNA biogenesis in Japanese encephalitis virus

Virology
Arthropod-borne flaviviruses produce subgenomic RNAs (sfRNAs) from the highly conserved 3'-untranslated region (UTR). While most flaviviruses generate sfRNAs by resisting degradation from the host exoribonuclease XRN1, Japanese encephalitis virus (JEV) maintains sfRNA production even when XRN1 is depleted, suggesting an alternative mechanism.
Ruey-Yi Chang
exaly   +3 more sources

Multiple orthoflaviviruses secrete sfRNA in mosquito saliva to promote transmission by inhibiting MDA5-mediated early interferon response

Nature Communications
Abstract Numerous orthoflaviviruses transmitted through the bites of different mosquito species infect more than 500 million people annually. Skin infection at the bite site represents a critical and conserved step in transmission and a deeper understanding of this process will promote the design of broad-spectrum ...
Florian Rachenne
exaly   +3 more sources

Diferentes orthoflavivirus producen sfRNA que promueve la transmisión viral al inhibir la respuesta interferón

Salud Uninorte
Introducción: Los ortoflavivirus transmitidos por mosquitos, como el virus del Nilo Occidental (WNV) y el virus Zika (ZIKV), causan cientos de millones de infecciones anuales y aún carecemos de intervenciones ampliamente eficaces. La transmisión se inicia con la deposición del virus en la piel durante la picadura; pero en presencia de una potente ...
Idalba Serrato Pomar, Hacène Medkour, Louise Belleville, Kachaporn Jintana, Lauryne Pruvost, Norman Schneider, Mihra Tavadia, Jim Zoladek, Florian Rachenne, Zoé Roux, Quentin Narpon, Felix Rey Cadilhac, Solena Rossi, Stephanie French, Cassandra Modahl, Wannapa Sornjai, Elliott Miot, Duncan Smith, Rodolphe Hamel, Oleg Medianikov, Dorothée Missé, Sébastien Nisole, Julien Pompon   +22 more
exaly   +2 more sources

Functional non-coding RNAs derived from the flavivirus 3′ untranslated region

Virus Research, 2015
Alexander A. Khromykh, Andrii Slonchak
exaly  

Subgenomic flaviviral RNAs: What do we know after the first decade of research

Antiviral Research, 2018
Alexander A. Khromykh, Andrii Slonchak
exaly