Results 91 to 100 of about 3,555 (225)

Clinical Factors Associated with SFTS Diagnosis and Severity in Cats [PDF]

Nagasaki University (長崎大学)博士(医学)Severe fever with thrombocytopenia syndrome (SFTS) is a potentially fatal tick-borne zoonosis caused by SFTS virus (SFTSV).
許, 強
core   +4 more sources

Unraveling the Underlying Interaction Mechanism Between Dabie bandavirus and Innate Immune Response

Frontiers in Immunology, 2021
The genus Bandavirus consists of seven tick-borne bunyaviruses, among which four are known to infect humans. Dabie bandavirus, severe fever with thrombocytopenia syndrome virus (SFTSV), poses serious threats to public health worldwide.
Chuan-min Zhou, Chuan-min Zhou, Xue-jie Yu   +2 more
doaj   +1 more source

Role of Atypical MAPK p38 Signaling in the Progression of Influenza A‐Induced Acute Lung Injury

The FASEB Journal, Volume 39, Issue 18, 30 September 2025.
Genetic block of TAB1‐dependent atypical p38 signaling reduces weight loss and early‐phase pathological markers in an influenza A virus‐induced lung injury model. ABSTRACT Mitogen‐activated protein kinase (MAPK) p38 plays a key role in driving the pathology of acute lung injury (ALI), but effective therapeutic targeting remains elusive.
Jeremy C. Burton, Denise L. Fahey, Fredejah T. Royer, Yin Zhu, Kaori Sakamoto, Duo Zhang, Wendy T. Watford, Neil J. Grimsey   +7 more
wiley   +1 more source

Cyclophilin A causes severe fever with thrombocytopenia syndrome virus-induced cytokine storm by regulating mitogen-activated protein kinase pathway

Frontiers in Microbiology, 2022
IntroductionSevere fever with thrombocytopenia syndrome (SFTS) has become a global threat to public health since its first report in China in 2009. However, the pathogenesis of SFTS virus (SFTSV) in humans remains unclear.
Huaying Huang, Huaying Huang, Ke Jin, Ke Ouyang, Zhengyi Jiang, Zhan Yang, Nannan Hu, Yan Dai, Yaqin Zhang, Qian Zhang, Ying Han, Jie Zhao, Hong Lin, Chunhui Wang, Chunyan Wang, Xuewei Sun, Dafeng Lu, Jin Zhu, Jun Li   +18 more
doaj   +1 more source

Non-Structural Protein-W61 as a Novel Target in Severe Fever with Thrombocytopenia Syndrome Virus (SFTSV): An In-Vitro and In-Silico Study on Protein-Protein Interactions with Nucleoprotein and Viral Replication [PDF]

, 2023
Ji-Young Park, Chandran Sivasankar, Perumalraja Kirthika, Dhamodharan Prabhu, John Hwa Lee   +4 more
openalex   +1 more source

Low Thoracic Muscle Mass: A Novel Indicator of Poor Prognosis in Patients With Severe Fever With Thrombocytopenia Syndrome

Immunity, Inflammation and Disease, Volume 13, Issue 9, September 2025.
Low thoracic muscle mass is associated with adverse outcomes in patients with severe fever with thrombocytopenia syndrome. Thoracic muscle mass may serve as a reliable prognostic marker for severe fever with thrombocytopenia syndrome in clinical settings.
Xiao‐Min Wang, Pu Li, Lei Hu, Xiao Zhang, Jun Wang, Cheng‐Xin Zhu, Kun Lv, Da‐Wei Zhang   +7 more
wiley   +1 more source

Advances in Single‐Cell Sequencing for Infectious Diseases: Progress and Perspectives

Advanced Science, Volume 12, Issue 32, August 28, 2025.
Single‐cell sequencing technologies uncover novel, unknown, and emergent features of many diseases. This review describes recent progress of single‐cell sequencing technologies and their applications in infectious diseases, summarizes the underlying commonalities of different infections and discusses future research directions, facilitating the ...
Mengyuan Lyu, Yang Liu, Jian Zhou, Hongli Lai, Hongxia Ruan, Dongsheng Wu, Shun Zhu, Xudong Zhou, Wananqi Ma, Yuchen Huang, Shuting Lei, Han Luo, Jie Chen, Binwu Ying   +13 more
wiley   +1 more source

The immunogenicity and protection efficacy evaluation of mRNA vaccine candidate for severe fever with thrombocytopenia syndrome in mice.

PLoS Neglected Tropical Diseases
Severe fever with thrombocytopenia syndrome virus (SFTSV) is a tick-borne viral pathogen that causes Severe fever with thrombocytopenia syndrome (SFTS) in humans with a high fatality rate.
Da-Eun Jeong, Jack Yoon, Baek Kim, Jun-Gu Kang   +3 more
doaj   +1 more source

Akkermansia Muciniphila Alleviates Severe Acute Pancreatitis via Amuc1409‐Ube2k‐Foxp3 Axis in Regulatory T Cells

Advanced Science, Volume 12, Issue 30, August 14, 2025.
Akkermansia depletion correlates with acute pancreatitis (AP) severity. A. muciniphila and its protein Amuc_1409 mitigate pancreatic/systemic inflammation by expanding Tregs and IL‐10. Mechanistically, Amuc_1409 binds Ube2k, inhibiting Foxp3 ubiquitination to stabilize Treg differentiation and IL‐10 production, countering SAP‐induced SIRS/CARS ...
Jinyan Xie, Lijun Du, Yunkun Lu, Xiuliu Guo, Xinyuan Zhou, Yifan Tong, Bo Shen, Xin Yu, Feng Guo, Hong Yu   +9 more
wiley   +1 more source

SFTSV nucleoprotein mediates DNA sensor cGAS degradation to suppress cGAS-dependent antiviral responses

Microbiology Spectrum
Cyclic GMP-AMP synthase (cGAS) is an important DNA pattern recognition receptor that senses double-stranded DNA derived from invading pathogens or self DNA in cytoplasm, leading to an antiviral interferon response.
Ze-zheng Jiang, Min Chu, Li-na Yan, Wen-kang Zhang, Bang Li, Jiao Xu, Zhong-xin Zhao, Hui-Ju Han, Chuan-min Zhou, Xue-jie Yu   +9 more
doaj   +1 more source