Results 71 to 80 of about 2,383 (169)

Antibody Development Strategies for SFTSV: From Hybridoma to Emerging Technologies

Viral Immunology
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging zoonotic disease caused by the tick-borne SFTS virus (SFTSV), with a case fatality rate of 16.2–32.6% in East Asia. Currently, no approved vaccines or antiviral treatments exist.
Wanqing Lu, Yan Liu, Boyu Zhang, Zhuo Guan, Zheng Xuan, Lingkun Jin, Mingsheng Qu   +6 more
openaire   +2 more sources

Efficacy of T-705 (Favipiravir) in the Treatment of Infections with Lethal Severe Fever with Thrombocytopenia Syndrome Virus

mSphere, 2016
Severe fever with thrombocytopenia syndrome virus (SFTSV) is the causative agent of SFTS, an emerging hemorrhagic fever. This disease has a high case fatality rate and is endemic to China, South Korea, and Japan.
Hideki Tani, Aiko Fukuma, Shuetsu Fukushi, Satoshi Taniguchi, Tomoki Yoshikawa, Naoko Iwata-Yoshikawa, Yuko Sato, Tadaki Suzuki, Noriyo Nagata, Hideki Hasegawa, Yasuhiro Kawai, Akihiko Uda, Shigeru Morikawa, Masayuki Shimojima, Haruo Watanabe, Masayuki Saijo   +15 more
doaj   +1 more source

Safety, Immunogenicity, and Efficacy of a Recombinant Vesicular Stomatitis Virus Vectored Vaccine Against Severe Fever with Thrombocytopenia Syndrome Virus and Heartland Bandavirus

Vaccines
Background: Severe fever with thrombocytopenia syndrome virus (SFTSV) is a recently emerged tickborne virus in east Asia with over 18,000 confirmed cases.
Philip Hicks, Tomaz B. Manzoni, Jonna B. Westover, Raegan J. Petch, Brianne Roper, Brian B. Gowen, Paul Bates   +6 more
doaj   +1 more source

Development of antibodies against severe fever with thrombocytopenia syndrome virus nucleoprotein for diagnosis

Applied Microbiology and Biotechnology
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging viral infectious disease caused by a novel Bandavirus in the family Phenuiviridae. The SFTS virus (SFTSV) is transmitted to various hosts, including humans, through tick bites, leading to ...
Eun-Mee Park, Seheon Kim, Seoyoen Lim, Parastou Rahimizadeh, Hyeyoon Jeon, Hyung Jin Lim, Sungjin Lee, Yong Bhum Song   +7 more
doaj   +1 more source

Design, Optimization, and Analytical Performance Evaluation of LAMP-Based Rapid Detection Assay for Severe Fever with Thrombocytopenia Syndrome Virus

Journal of Pharmacopuncture
Objectives: Severe Fever with Thrombocytopenia Syndrome Virus (SFTSV), a tick-borne pathogen, presents a growing public health threat in East Asia.
Han-Heom Na, Hee-Jeong Youk, In Bum Suh, Sang Hoon Lee, Yoonsung Kang, Keun-Cheol Kim   +5 more
doaj   +1 more source

Adenovirus type 5-expressing Gn induces better protective immunity than Gc against SFTSV infection in mice

npj Vaccines
Severe fever with thrombocytopenia syndrome (SFTS) is caused by the SFTS virus (SFTSV) with high morbidity and mortality. The major immunodominant region of SFTSV surface glycoprotein (G) remains unclear.
Hua Qian, Li Tian, Wenkai Liu, Lele Liu, Menghua Li, Zhongxin Zhao, Xiaoying Lei, Wenwen Zheng, Zhongpeng Zhao, Xuexing Zheng   +9 more
doaj   +1 more source

SFTSV NSs interacts with AGO2 to regulate the RNAi pathway for viral replication

Journal of Virology
ABSTRACT RNA interference (RNAi) is a posttranscriptional gene silencing mechanism acting as an antiviral defense in eukaryotes. During viral replication, intermediate double-stranded RNAs are processed into virus-derived small interfering RNAs (vsiRNAs) by the host enzyme, DICER.
Nasir Javaid, Tae-Won Jang, Yuting Fu, Younho Choi   +3 more
openaire   +2 more sources

Additional file 1 of Antibody production and characterization of the nucleoprotein of sever fever with thrombocytopenia syndrome virus (SFTSV) for effective diagnosis of SFTSV

Additional file 1. Sequence and epitope characteristic analysis of the SFTSV N protein, and pair test of generated antibodies.
Lee, Kyungha, Choi, Min Ji, Cho, Man-Ho, Choi, Dong Ok, Bhoo, Seong-Hee   +4 more
openaire   +1 more source

Seasonal dynamics of Haemaphysalis tick species as SFTSV vectors in South Korea

Microbiology Spectrum
ABSTRACT Ticks pose a significant public health threat due to their ability to transmit various pathogens, including emerging tick-borne diseases. This study conducted a comprehensive surveillance of Haemaphysalis tick species and their severe fever with thrombocytopenia ...
Hyunwoo Jang, Mark Anthony B. Casel, Seung-gyu Jang, Jeong Ho Choi, Juryeon Gil, Rare Rollon, So youn Cheun, Young-Il Kim, Min Suk Song, Young Ki Choi   +9 more
openaire   +3 more sources

Changes in Cytokine Levels in Patients with Severe Fever with Thrombocytopenia Syndrome Virus

Journal of Inflammation Research
Da-Li Xu,1 Xiao-Mei Zhang,2 Xue-Ying Tian,2 Xian-Jun Wang,2 Lin Zhao,1 Meng-Ying Gao,1 Lian-Feng Li,1 Jia-Qi Zhao,1 Wu-Chun Cao,1,3,* Shu-Jun Ding2,* 1Department of Epidemiology, School of Public Health, Cheeloo College of Medicine, Shandong ...
Xu DL, Zhang XM, Tian XY, Wang XJ, Zhao L, Gao MY, Li LF, Zhao JQ, Cao WC, Ding SJ   +9 more
doaj