Results 81 to 90 of about 3,280 (212)
SAFA is involved in detecting SFTSV NP and RNA in the cytoplasm.
, 2021 (A-B) MEF cells were infected with or without SFTSV (MOI = 10) for 24 h, interaction between the S (A) or M (B) segment of SFTSV RNA and SAFA was detected by RIP. (C-D) MEF cells were transfected with Flag-tagged SFTSV NP for 24 h, and the purified SFTSV
Xue-jie Yu (523802) +2 more
core +1 more source
PLoS Neglected Tropical DiseasesSevere fever with thrombocytopenia syndrome virus (SFTSV) is a tick-borne viral pathogen that causes Severe fever with thrombocytopenia syndrome (SFTS) in humans with a high fatality rate.
Da-Eun Jeong +3 more
doaj +1 more source
Advanced Science, Volume 13, Issue 12, 27 February 2026.Amid the ongoing threat of emerging viral pathogens, host‐directed antivirals offer a strategy to overcome viral mutation and drug resistance. SB2960, a small‐molecule inducer of stress granules (SGs), exhibits potent broad‐spectrum antiviral activity with minimal cytotoxicity.
Wan Gi Byun +14 more
wiley +1 more source
Animal Models and Experimental Medicine, Volume 9, Issue 2, Page 378-388, February 2026.Humanized mouse models are essential for studying human immune response and antibody development. However, conventional models exhibit limited B cell maturation and antigen‐specific humoral responses. To overcome these limitations, we used the NOG‐EXL mice expressing human interleukin 3 (IL‐3) and granulocyte‐macrophage colony‐stimulating factor (GM ...
Dong Hoon Lee +11 more
wiley +1 more source
Insect Science, Volume 33, Issue 1, Page 396-406, February 2026.Lipid analysis of field‐collected ticks unveiled a complex population structure and supports the potential for several stages to overwinter. Abstract The seasonality of Haemaphysalis longicornis in the United States comprises overlapping life stages in the spring and summer.
Matthew Bickerton +2 more
wiley +1 more source
SFTSV infection drives translocation of SAFA to activate the STING-TBK1 mediated antiviral response.
, 2021 (A) MEF cells were infected with or without SFTSV (MOI = 10) for 48 h, SFTSV NP (purple), SAFA (green), STING (red), and DAPI (blue) were analyzed by confocal microscopy. (B) MEF cells were infected with or without SFTSV (MOI = 10) for 48 h.
Xue-jie Yu (523802) +2 more
core +1 more source
Laboratory Animal Research, 2020 Severe fever with thrombocytopenia syndrome (SFTS) is an emerging zoonotic disease, which causes high fever, thrombocytopenia, and death in humans and animals in East Asian countries. The pathogenicity of SFTS virus (SFTSV) remains unclear.
Seok-Chan Park +10 more
doaj +1 more source
RNAi Regulator C3PO Promotes Arbovirus Infection in Insect Vectors
Advanced Science, Volume 13, Issue 4, 19 January 2026.RNA interference (RNAi) is vital for eukaryotes to defend against virus infection. The C3PO complex takes part in RNAi but its role in regulating viral infection remains unclear. This work finds that insect C3PO facilitates arbovirus replication by degrading precursors of miRNAs, especially miR‐971‐3p.
Yan Xiao +7 more
wiley +1 more source
SFTSV inhibits exogenous Type I IFN signaling pathway.
, 2017 (A)SFTSV inhibits the phosphorylation of STAT1. Hela cells were infected with SFTSV(MOI = 1.0) for2 hours and cultured for 36 hours before 100IU/ml IFNα was added for 15 minutes,and total protein were collected for WB and densitometry analysis for p ...
Baihai Jiao (3779428) +6 more
core +1 more source
Strategic Preparedness of Broad‐Spectrum Antivirals for Rapid Response Towards Next Pandemics
Small Science, Volume 6, Issue 1, January 2026.Nanoengineered broad‐spectrum antivirals (BSAs) represent a transformative approach to pandemic preparedness. Unlike virus‐specific drugs requiring separate development, BSAs act across multiple viral families through nanoengineering strategies that enhance solubility, bioavailability, and host‐targeted activity.
Sanoj Rejinold N +2 more
wiley +1 more source