Results 81 to 90 of about 2,383 (169)

Molecular mechanism and structure-guided humanization of a broadly neutralizing antibody against SFTSV.

PLoS Pathogens
Severe fever with thrombocytopenia syndrome virus (SFTSV) is a novel tick-borne bunyavirus that causes severe fever with thrombocytopenia syndrome (SFTS), with a high mortality rate of up to 30%.
Pinyi Yang, Xiaoli Wu, Hang Shang, Zixian Sun, Zhiying Wang, Zidan Song, Hong Yuan, Fei Deng, Shu Shen, Yu Guo, Nan Zhang   +10 more
doaj   +1 more source

Genome-wide CRISPR screening identifies LRP1 as an entry factor for SFTSV

Nature Communications
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging tick-borne disease caused by the SFTS virus (SFTSV), which has high mortality rates and poses a significant threat to public health. To identify potential therapeutic targets against SFTSV, we conduct genome-wide knockout screening, which identifies the previously known host factor CCR2,
Chen Xing, Cong Zhang, Zhihao Xu, Yajie Wang, Wanqing Lu, Xiaohan Liu, Yingying Zhang, Jingyuan Ma, Shuqi Yang, Yinan Du, Gang Xu, Yan Liu   +11 more
openaire   +3 more sources

Seroprevalence and transmission of severe fever with thrombocytopenia syndrome virus in a coastal endemic area in Southeastern China

Ticks and Tick-Borne Diseases
Severe fever with thrombocytopenia syndrome (SFTS) is a newly emerged tick-borne viral zoonosis and widely prevalent in China, Japan and South Korea. Most reported SFTS cases have been identified in mountainous and hilly areas, with a few in island areas.
Zhipeng Zu, Haijiang Lin, Yafei Hu, Xiang Zheng, Cairong Chen, Yishuang Zhao, Zhiyi Zhang, Na He   +7 more
doaj   +1 more source

An orally available 4 ' -fluorouridine prodrug inhibits SFTSV and LCMV infection

Journal of Virology
ABSTRACT Bunyaviruses, a subset of segmented negative-sense RNA viruses, include pathogenic species capable of zoonotic transmission to humans via arthropod vectors and rodent hosts.
Xiaoqin Jian, Tianwen Hu, Huan Xu, Yuxi Wen, Yumin Zhang, Mengwei Xu, Xiaming Jiang, Junyuan Cao, Li Xiang, Jingshan Shen, Guanghui Tian, Gengfu Xiao, Leike Zhang   +12 more
openaire   +2 more sources

Discovery and characterization of potent broadly neutralizing antibodies from human survivors of severe fever with thrombocytopenia syndromeResearch in context

EBioMedicine
Summary: Background: Severe fever with thrombocytopenia syndrome virus (SFTSV) is an emerging tick-borne phlebovirus that causes viral hemorrhagic fever.
Shuo Zhang, Hang Shang, Shuo Han, Jiachen Li, Xuefang Peng, Yongxiang Wu, Xin Yang, Yu Leng, Fengze Wang, Ning Cui, Lingjie Xu, Hongkai Zhang, Yu Guo, Xiaoyu Xu, Nan Zhang, Wei Liu, Hao Li   +16 more
doaj   +1 more source

hnRNPA2B1 recognizes RNA virus SFTSV infection through mitochondrial DNA

mBio
ABSTRACT The heterogeneous nuclear ribonucleoprotein (hnRNPA2B1, hereafter A2B1) was identified as a novel nuclear DNA sensor that mediates antiviral immunity by recognizing viral DNA in the nucleus.
Xin-bo Huang, Yue Zhang, Jing-wen Fan, Xin-yu Yu, Yun-lan Fang, Jin-xin Ren, Bin-yan Liu   +6 more
openaire   +2 more sources

Origins of HIV, HCoV-HKU1, SFTSV, and MERS-CoV and Beyond

China CDC Weekly, 2022
Liu, Wenli, Liu, Peipei, Liu, William J, Wang, Qihui, Tong, Yigang, Gao, George F.   +5 more
openaire   +2 more sources

SFTSV-Nluc: a useful tool for studying SFTSV biology and countermeasures

eBioMedicine
Haoran Sun, Zi-Wei Ye, Shuofeng Yuan
openaire   +3 more sources

Subcellular localization of nucleocapsid protein of severe fever with thrombocytopenia syndrome virus (SFTSV) and characterization of quasi-species of SFTSV

Subcellular localization of nucleocapsid protein of severe fever with thrombocytopenia syndrome virus (SFTSV) and characterization of quasi-species of SFTSV
(主査) 教授 苅和 宏明, 教授 中島 千絵, 准教授 松野 啓太, 准教授 新開 大史, 准教授 吉松 組子 国際感染症学院（感染症学専攻）
openaire  

Genomic and phylogenetic characterization of severe fever with thrombocytopenia syndrome virus in companion animals in Korea, 2023-2024. [PDF]

PLoS Negl Trop Dis
Lee DY, Lee HJ, Choi HY, Park JS, Lee DH.   +4 more
europepmc   +1 more source