Results 61 to 70 of about 2,383 (169)

SFTSV nucleoprotein mediates DNA sensor cGAS degradation to suppress cGAS-dependent antiviral responses

Microbiology Spectrum
Cyclic GMP-AMP synthase (cGAS) is an important DNA pattern recognition receptor that senses double-stranded DNA derived from invading pathogens or self DNA in cytoplasm, leading to an antiviral interferon response.
Ze-zheng Jiang, Min Chu, Li-na Yan, Wen-kang Zhang, Bang Li, Jiao Xu, Zhong-xin Zhao, Hui-Ju Han, Chuan-min Zhou, Xue-jie Yu   +9 more
doaj   +1 more source

Interferon-γ-Directed Inhibition of a Novel High-Pathogenic Phlebovirus and Viral Antagonism of the Antiviral Signaling by Targeting STAT1

Frontiers in Immunology, 2019
Severe fever with thrombocytopenia syndrome (SFTS) is a life-threatening infectious disease caused by a novel phlebovirus, SFTS virus (SFTSV). Currently, there is no vaccine or antiviral available and the viral pathogenesis remains largely unknown.
Yun-Jia Ning, Qiong Mo, Qiong Mo, Kuan Feng, Kuan Feng, Yuan-Qin Min, Mingyue Li, Dianhai Hou, Cheng Peng, Xin Zheng, Fei Deng, Zhihong Hu, Hualin Wang   +12 more
doaj   +1 more source

Strategic Preparedness of Broad‐Spectrum Antivirals for Rapid Response Towards Next Pandemics

Small Science, Volume 6, Issue 1, January 2026.
Nanoengineered broad‐spectrum antivirals (BSAs) represent a transformative approach to pandemic preparedness. Unlike virus‐specific drugs requiring separate development, BSAs act across multiple viral families through nanoengineering strategies that enhance solubility, bioavailability, and host‐targeted activity.
Sanoj Rejinold N, Geun‐woo Jin, Jin‐Ho Choy   +2 more
wiley   +1 more source

A Novel Machine Learning Approach for Predicting Prognosis of SFTS Patients in the Early Stages of Disease

Canadian Journal of Infectious Diseases and Medical Microbiology, Volume 2026, Issue 1, 2026.
Objective Severe fever with thrombocytopenia syndrome (SFTS) is an emerging tick‐borne disease characterized by high morbidity and mortality rates. Timely detection and prognosis prediction are critical for implementing effective clinical interventions.
Siqi Li, Ting Wang, Rujia Chen, Yun Wang, Renren Ouyang, Wei Wei, Feng Wang, Shiji Wu, Hongyan Hou, Mahmoud Elhaig   +9 more
wiley   +1 more source

T Follicular Helper Cell Immune Signatures Associated With Disease Severity in Severe Fever With Thrombocytopenia Syndrome

Journal of Immunology Research, Volume 2026, Issue 1, 2026.
Background Severe fever with thrombocytopenia syndrome (SFTS) is marked by high case fatality and profound antiviral immune dysregulation, yet the clinical implications of changes in circulating T follicular helper (Tfh) cells remain unclear. Methods We enrolled 79 patients with RT‐PCR‐confirmed SFTSV infection who were hospitalized from May to October
Danning Xu, Ting Wang, Wei Wei, Yun Wang, Rujia Chen, Renren Ouyang, Shiji Wu, Feng Wang, Hongyan Hou, Poorani Gurumallesh Prabu   +9 more
wiley   +1 more source

Distribution of Ticks and Prevalence of Tick‐Borne Pathogens in Multiple Regions of China

Transboundary and Emerging Diseases, Volume 2026, Issue 1, 2026.
Ticks and tick‐borne pathogens pose significant threats to livestock and public health. While tick occurrences have been reported in China, systematic assessments of pathogen risk factors across diverse hosts and regions remain limited. This study investigated tick distribution, prevalence, and associated pathogen infections across seven sampling sites
Yichen Jian, Shunli Lu, Dongliang Li, Yifei Liu, Sumei Zhang, Longxian Zhang, Senyang Li, Fuchun Jian, Ruofeng Yan   +8 more
wiley   +1 more source

Analysis of Gene Differences Between F and B Epidemic Lineages of Bandavirus Dabieense

Microorganisms
The prevalence of SFTS is becoming increasingly widespread and is expected to become a significant security issue. The article discusses the prevalence regions and genetic differences in two SFTSV lineages, so as to provide a scientific data basis for ...
Wenzhou Ma, Yujia Hao, Chengcheng Peng, Duo Zhang, Yuge Yuan, Pengpeng Xiao, Nan Li   +6 more
doaj   +1 more source

A One Health Assessment of Tick and Tick‐Borne Pathogen Diversity and Zoonotic Risk in Hubei Province, Central China

Transboundary and Emerging Diseases, Volume 2026, Issue 1, 2026.
Ticks and tick‐borne pathogens (TBPs) threaten livestock productivity and public health worldwide, and climate–land‐use change is expanding vector habitats, elevating tick‐borne disease risk. However, TBP diversity and risk in Hubei Province, central China, remain insufficiently defined within a One Health framework.
Qian Chen, Ning-wei Ma, Shi-ying Zhu, Dong-fang Li, Xiao-yan Lei, Zi-qian Zhou, Fen Du, Lan He, Jun-long Zhao, Ruofeng Yan   +9 more
wiley   +1 more source

Novel Bunyavirus in Domestic and Captive Farmed Animals, Minnesota, USA

Emerging Infectious Diseases, 2014
Roger S. Nasci, Aaron C. Brault, Amy J. Lambert, Harry M. Savage   +3 more
doaj   +3 more sources

Animals as amplification hosts in the spread of severe fever with thrombocytopenia syndrome virus: A systematic review and meta-analysis

International Journal of Infectious Diseases, 2019
Objectives: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging tick-borne infectious disease caused by severe fever with thrombocytopenia syndrome virus (SFTSV).
Can Chen, Peng Li, Ke-Feng Li, Hong-Ling Wang, Ya-Xin Dai, Xi Cheng, Jian-Bo Yan   +6 more
doaj   +1 more source