Results 91 to 100 of about 3,280 (212)

Knockout of SAFA reduces immune responses induced by SFTSV infection.

, 2021
(A) Knockout of SAFA in THP-1 cells and MEF cells, identified by Western blot. (B-C) WT and SAFA-/- MEF cells were infected with SFTSV (MOI = 10) for 48 h, IFNβ mRNA level was detected by RT-PCR (B), IFNβ cytokine levels were analyzed by ELISA (C).
Xue-jie Yu (523802), Chuan-min Zhou (8861861), Bin-yan Liu (11719054)   +2 more
core   +1 more source

SFTSV nucleoprotein mediates DNA sensor cGAS degradation to suppress cGAS-dependent antiviral responses

Microbiology Spectrum
Cyclic GMP-AMP synthase (cGAS) is an important DNA pattern recognition receptor that senses double-stranded DNA derived from invading pathogens or self DNA in cytoplasm, leading to an antiviral interferon response.
Ze-zheng Jiang, Min Chu, Li-na Yan, Wen-kang Zhang, Bang Li, Jiao Xu, Zhong-xin Zhao, Hui-Ju Han, Chuan-min Zhou, Xue-jie Yu   +9 more
doaj   +1 more source

A Novel Machine Learning Approach for Predicting Prognosis of SFTS Patients in the Early Stages of Disease

Canadian Journal of Infectious Diseases and Medical Microbiology, Volume 2026, Issue 1, 2026.
Objective Severe fever with thrombocytopenia syndrome (SFTS) is an emerging tick‐borne disease characterized by high morbidity and mortality rates. Timely detection and prognosis prediction are critical for implementing effective clinical interventions.
Siqi Li, Ting Wang, Rujia Chen, Yun Wang, Renren Ouyang, Wei Wei, Feng Wang, Shiji Wu, Hongyan Hou, Mahmoud Elhaig   +9 more
wiley   +1 more source

Seroprevalence of SFTSV in healthy human volunteers in Laizhou.

, 2016
Seroprevalence of SFTSV in healthy human volunteers in Laizhou.
Mifang Liang (158706), Jinping Li (108282), Xianjun Wang (132239), Xue-jie Yu (523802), Shujun Ding (414103), Guoyu Niu (2221960), Naijie Zhang (2221969), Shiwen Wang (132242), Xuehua Xu (63390), Xiaomei Zhang (147359), Haiying Yin (2221966), Xiaolin Jiang (2221963)   +11 more
core   +1 more source

Interferon-γ-Directed Inhibition of a Novel High-Pathogenic Phlebovirus and Viral Antagonism of the Antiviral Signaling by Targeting STAT1

Frontiers in Immunology, 2019
Severe fever with thrombocytopenia syndrome (SFTS) is a life-threatening infectious disease caused by a novel phlebovirus, SFTS virus (SFTSV). Currently, there is no vaccine or antiviral available and the viral pathogenesis remains largely unknown.
Yun-Jia Ning, Qiong Mo, Qiong Mo, Kuan Feng, Kuan Feng, Yuan-Qin Min, Mingyue Li, Dianhai Hou, Cheng Peng, Xin Zheng, Fei Deng, Zhihong Hu, Hualin Wang   +12 more
doaj   +1 more source

Integration of SFTSV Viral Load, Age, and Double‐Negative B‐Cells as Prognostic Biomarkers for Severe Fever With Thrombocytopenia Syndrome Outcomes

Journal of Immunology Research, Volume 2026, Issue 1, 2026.
Background Severe fever with thrombocytopenia syndrome (SFTS) is a tick‐borne viral illness with high mortality, yet early risk stratification remains challenging. Recent evidence suggests that B‐cell dysregulation contributes to disease severity. Methods A cohort of 168 patients with confirmed SFTS was retrospectively analyzed. Flow cytometry was used
Wei Wei, Qian Tai, Heng Liu, Rujia Chen, Yun Wang, Ting Wang, Renren Ouyang, Shiji Wu, Feng Wang, Hongyan Hou, Poorani Gurumallesh   +10 more
wiley   +1 more source

Analysis of Gene Differences Between F and B Epidemic Lineages of Bandavirus Dabieense

Microorganisms
The prevalence of SFTS is becoming increasingly widespread and is expected to become a significant security issue. The article discusses the prevalence regions and genetic differences in two SFTSV lineages, so as to provide a scientific data basis for ...
Wenzhou Ma, Yujia Hao, Chengcheng Peng, Duo Zhang, Yuge Yuan, Pengpeng Xiao, Nan Li   +6 more
doaj   +1 more source

T Follicular Helper Cell Immune Signatures Associated With Disease Severity in Severe Fever With Thrombocytopenia Syndrome

Journal of Immunology Research, Volume 2026, Issue 1, 2026.
Background Severe fever with thrombocytopenia syndrome (SFTS) is marked by high case fatality and profound antiviral immune dysregulation, yet the clinical implications of changes in circulating T follicular helper (Tfh) cells remain unclear. Methods We enrolled 79 patients with RT‐PCR‐confirmed SFTSV infection who were hospitalized from May to October
Danning Xu, Ting Wang, Wei Wei, Yun Wang, Rujia Chen, Renren Ouyang, Shiji Wu, Feng Wang, Hongyan Hou, Poorani Gurumallesh Prabu   +9 more
wiley   +1 more source

Novel Bunyavirus in Domestic and Captive Farmed Animals, Minnesota, USA

Emerging Infectious Diseases, 2014
Roger S. Nasci, Aaron C. Brault, Amy J. Lambert, Harry M. Savage   +3 more
doaj   +3 more sources

Development of recombinant vaccine against Severe Fever with Thrombocytopenia Syndrome Virus (SFTSV) [PDF]

, 2020
학위논문 (석사) -- 서울대학교 대학원 : 의과대학 의과학과, 2020. 8. 조남혁.Severe Fever with Thrombocytopenia Syndrome virus (SFTSV) is an emerging tick-borne virus which causes SFTS disease with a mortality rate of 5-27% in humans.
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