Results 101 to 110 of about 4,025 (237)

Broad‐Spectrum Antiviral Agents against SARS‐CoV‐2 Variants Inhibit the Conserved Viral Protein Nsp1–RNA Interaction

Angewandte Chemie, Volume 136, Issue 47, November 18, 2024.
The demand for robust antiviral approaches is underscored by the continued COVID‐19 spread. SARS‐CoV‐2 Nsp1, highly conserved among SARS‐CoV‐2 variants, plays a pivotal role in controlling host protein expression and viral RNA translation. A small‐molecule Nsp1 inhibitor exhibited antiviral activity against various sarbecoviruses, signifying a ...
Wan Gi Byun, Minha Lee, Meehyun Ko, Ji Hyae Lee, Sihyeong Yi, JinAh Lee, Seungtaek Kim, Seung Bum Park   +7 more
wiley   +2 more sources

Growth Arrest and DNA Damage Protein 45A Promotes PPRV Replication via the Downregulation of TBK1 Expression to Inhibit IFN‐β Signaling Pathway

The FASEB Journal, Volume 39, Issue 12, 30 June 2025.
A working model of host protein GADD45A regulation of PPRV replication. During PPRV infection, the viral protein V forms a complex with GADD45A in the cytoplasm. GADD45A interacts with TBK1 and inhibits its expression. Similarly, V also interacts with TBK1 and inhibits TBK1 expression.
Haiyan Ding, Wenping Yang, Jinyan Wu, Junhuang Wu, Mengyi Wang, Jijun He, Ligang Yuan, Haixue Zheng, Youjun Shang, Dan Li   +9 more
wiley   +1 more source

Severe Fever with Thrombocytopenia Syndrome Virus in Dogs, South Korea

Emerging Infectious Diseases, 2019
Of 103 serum samples collected from dogs in South Korea, 3 (2.9%) were positive for severe fever with thrombocytopenia syndrome virus (SFTSV) and 22 (21.4%) were positive for antibodies against SFTSV.
Jun-Gu Kang, Yoon-Kyoung Cho, Young-Sun Jo, Jeong-Byoung Chae, Young-Hoon Joo, Kyoung-Wan Park, Joon-Seok Chae   +6 more
doaj   +1 more source

Molecular genomic characterization of tick- and human-derived severe fever with thrombocytopenia syndrome virus isolates from South Korea. [PDF]

PLoS Neglected Tropical Diseases, 2017
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging tick-borne viral disease caused by the SFTS virus (SFTSV) from Bunyaviridae that is endemic in East Asia.
Seok-Min Yun, Su-Jin Park, Sun-Whan Park, WooYoung Choi, Hye Won Jeong, Young-Ki Choi, Won-Ja Lee   +6 more
doaj   +1 more source

Cross-genotype protection of live-attenuated vaccine candidate for severe fever with thrombocytopenia syndrome virus in a ferret model [PDF]

, 2019
Severe fever with thrombocytopenia syndrome (SFTS) virus (SFTSV) is an emerging tick-borne virus classified within the Banyangvirus genus. SFTS disease has been reported throughout East Asia since 2009 and is characterized by high fever, thrombocytopenia,
Brennan, Benjamin, Choi, Young Ki, Choi, Younho, Jung, Jae U., Kim, Young-Il, Park, Su-Jin, Yu, Kwang-Min, Yu, Min-Ah   +7 more
core   +1 more source

Engineered Biomolecular Condensates Limit Tobacco Mosaic Virus Accumulation and Symptom Development

Molecular Plant Pathology, Volume 26, Issue 6, June 2025.
Artificial biomolecular condensates were designed to target engineered tobacco mosaic virus using the MS2‐MCP tagging system. ABSTRACT Artificial condensates formed by liquid–liquid phase separation (LLPS) have been extensively studied in the field of synthetic biology for their ability to control cellular functions in a reversible and tunable manner ...
Alyssa M. Stanfield, Jared P. May
wiley   +1 more source

High Seroprevalence of Severe Fever with Thrombocytopenia Syndrome Virus Infection among the Dog Population in Thailand

Viruses, 2023
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging tick-borne zoonotic disease caused by the SFTS virus (SFTSV). In Thailand, three human cases of SFTS were reported in 2019 and 2020, but there was no report of SFTSV infection in animals ...
Keita Ishijima, Thanmaporn Phichitraslip, Nattakarn Naimon, Preeyaporn Ploypichai, Benyapa Kriebkajon, Torntun Chinarak, Jirasin Sridaphan, Anamika Kritiyakan, Noppadol Prasertsincharoen, Sathaporn Jittapalapong, Kanate Tangcham, Worawut Rerkamnuaychoke, Yudai Kuroda, Masakatsu Taira, Kango Tatemoto, Eunsil Park, Milagros Virhuez-Mendoza, Yusuke Inoue, Michiko Harada, Tsukasa Yamamoto, Ayano Nishino, Aya Matsuu, Ken Maeda   +22 more
doaj   +1 more source

Plant viruses convergently target NPR1 with various strategies to suppress salicylic acid‐mediated antiviral immunity

Journal of Integrative Plant Biology, Volume 67, Issue 5, Page 1395-1412, May 2025.
Viral infection triggers monomerization and nuclear translocation of the salicylic acid receptor NONEXPRESSOR OF PATHOGENESIS‐RELATED GENES1 (NPR1) to activate pathogenesis‐related gene expression. Nevertheless, viruses have developed one or more proteins to target NPR1 and impair its functionality through mechanisms such as inducing its degradation ...
Xue Jiang, Yingshuai Yang, Yong Li, Yongzhi Wang, Bernardo Rodamilans, Weiqin Ji, Xiaoxia Wu, Juan Antonio García, Xiaoyun Wu, Xiaofei Cheng   +9 more
wiley   +1 more source

Multiple Introductions of the Asian Longhorned Tick (Haemaphysalis longicornis) to the United States Revealed Using Mitogenomics

Ecology and Evolution, Volume 15, Issue 4, April 2025.
The Asian longhorned tick, Haemaphysalis longicornis, is a significant global vector and threat to both agriculture and public health. Formerly known only in the Eastern Hemisphere, parthenogenetic ALT have been reported from 20 states across the eastern and central US, with a pattern of expansion suggestive of multiple distinct populations.
Zoe E. Narvaez, Andrea M. Egizi, Michael J. Yabsley, Alec T. Thompson, Mohamed Moustafa, Erika Alt, Matthew Bickerton, Kim Bjorgo, Rebecca A. Butler, Alexandra Cumbie, Gillian Eastwood, Richard C. Falco, Dina M. Fonseca, Jun Hang, Vanessa L. Harper, Nicole Lewis, Jan Lovy, Lauren P. Maestas, Thomas N. Mather, Ryo Nakao, James L. Occi, Tadhgh Rainey, Melanie Sal, Craig A. Stoops, Rebecca T. Trout‐Fryxell, Wes Watson, Nicole E. Wagner, Aihua Zheng, Perot Saelao, Dana C. Price   +29 more
wiley   +1 more source

Vascular Leak and Hypercytokinemia Associated with Severe Fever with Thrombocytopenia Syndrome Virus Infection in Mice [PDF]

, 2019
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging viral hemorrhagic fever (VHF) endemic to China, South Korea, Japan, and Vietnam. Here we characterize the pathogenesis and natural history of disease in IFNAR-/- mice challenged with the ...
Dagley, Ashley, Furuta, Yousuke, Gowen, Brian B., Hickerson, Brady T., Hurst, Brett L., Komeno, Takashi, Kurz, Jacqueline P., Steiner, Thomas, Van Wettere, Arnaud J., Westover, Jonna B., Wülfroth, Petra   +10 more
core   +2 more sources