Results 11 to 20 of about 3,481 (207)

Antibody production and characterization of the nucleoprotein of sever fever with thrombocytopenia syndrome virus (SFTSV) for effective diagnosis of SFTSV

Virology Journal, 2023
Background Severe fever with thrombocytopenia syndrome (SFTS) is an infectious disease caused by the Dabie bandavirus, [or SFTS virus (SFTSV)] that has become increasingly widespread since it was first reported in 2009.
Kyungha Lee, Min Ji Choi, Man-Ho Cho, Dong Ok Choi, Seong-Hee Bhoo   +4 more
doaj   +3 more sources

Investigation into the Pancreatic Pathogenesis of SFTSV across Multiple Levels. [PDF]

Adv Sci (Weinh)
A retrospective analysis revealed that 17.6% of severe fever with thrombocytopenia syndrome (SFTS) patients met the diagnostic criteria for clinically confirmed pancreatitis. Using human pancreatic organoids and murine models demonstrated that SFTSV exhibits a specific pancreatic tropism, leading to cell death and initiating a strong inflammatory ...
Liu X, Xu Z, Tong Y, Wang C, Yao Y, Diao Y, Ma J, Zhou S, Du Y, Zhang Z, Xu G.   +10 more
europepmc   +3 more sources

SFTSV Infection Induced Interleukin-1β Secretion Through NLRP3 Inflammasome Activation [PDF]

Frontiers in Immunology, 2021
Severe fever with thrombocytopenia syndrome virus (SFTSV) is an emerging tick-borne virus that causes hemorrhagic fever. Previous studies showed that SFTSV-infected patients exhibited elevated levels of pro-inflammatory cytokines like interleukin-1β (IL ...
Jian-Wei Liu, Min Chu, Yong-jun Jiao, Chuan-Min Zhou, Rui Qi, Xue-jie Yu   +5 more
doaj   +3 more sources

The cap-snatching SFTSV endonuclease domain is an antiviral target [PDF]

Cell Reports, 2020
Severe fever with thrombocytopenia syndrome virus (SFTSV) is a tick-borne virus with 12%-30% case mortality rates and is related to the Heartland virus (HRTV) identified in the United States.
Amarasinghe, Gaya K, Bowman, Gregory R, Choi, Younho, Frederick, Thomas E, Gross, Michael L, Jung, Jae U, Leung, Daisy W, Shin, Woo-Jin, Wang, Wenjie, Yoo, Ji-Seung, Zhang, Bojie, Zimmerman, Maxwell I   +11 more
core   +7 more sources

A humanized NOG-EXL mouse model for producing severe fever with thrombocytopenia syndrome virus-reactive human antibodies. [PDF]

Animal Model Exp Med
Humanized mouse models are essential for studying human immune response and antibody development. However, conventional models exhibit limited B cell maturation and antigen‐specific humoral responses. To overcome these limitations, we used the NOG‐EXL mice expressing human interleukin 3 (IL‐3) and granulocyte‐macrophage colony‐stimulating factor (GM ...
Lee DH, Bae J, Kim S, Song CY, Shin JH, Kim EH, Jang CH, Yun YS, Lee DS, Chu H, Choi JH, Kim CW.   +11 more
europepmc   +2 more sources

<i>Bandavirus dabieense</i> Isolated From a Wild Leopard Cat (<i>Prionailurus bengalensis euptilura</i>) in the Republic of Korea. [PDF]

Transbound Emerg Dis
Bandavirus dabieense severe fever with thrombocytopenia syndrome virus (SFTSV) is an emerging tick‐borne zoonotic virus that causes severe febrile illness and high fatality rates in people. SFTSV is endemic to East Asia, notably in the Republic of Korea (ROK), Japan, and China.
Byun HR, Chae SJ, Ji SR, Shin HS, Kang JG, Jeong H, Lee S, Chae JS.   +7 more
europepmc   +2 more sources

Molecular mechanism and structure-guided humanization of a broadly neutralizing antibody against SFTSV.

PLoS Pathogens
Severe fever with thrombocytopenia syndrome virus (SFTSV) is a novel tick-borne bunyavirus that causes severe fever with thrombocytopenia syndrome (SFTS), with a high mortality rate of up to 30%.
Pinyi Yang, Xiaoli Wu, Hang Shang, Zixian Sun, Zhiying Wang, Zidan Song, Hong Yuan, Fei Deng, Shu Shen, Yu Guo, Nan Zhang   +10 more
doaj   +3 more sources

Bunyavirus SFTSV exploits autophagic flux for viral assembly and egress [PDF]

Autophagy, 2021
Severe fever with thrombocytopenia syndrome virus (SFTSV) is an emerging negatively stranded enveloped RNA bunyavirus that causes SFTS with a high case fatality rate of up to 30%. Macroautophagy/autophagy is an evolutionarily conserved process involved in the maintenance of host homeostasis, which exhibits anti-viral or pro-viral responses in reaction ...
Yan, Jia-min, Zhang, Wen-kang, Yan, Li-na, Jiao, Yong-Jun, Zhou, Chuan-min, Yu, Xue-jie   +5 more
openaire   +2 more sources

Immunization with Recombinant SFTSV/NSs Protein Does Not Promote Virus Clearance in SFTSV-Infected C57BL/6J Mice [PDF]

Viral Immunology, 2015
The severe fever with thrombocytopenia syndrome (SFTS), caused by a novel Phlebovirus in the Bunyaviridae family named SFTS virus (SFTSV), is an emerging hemorrhagic fever with a wide distribution and high case-fatality rate. Neither effective treatment nor vaccines are available to treat and prevent this disease to date.
Rong, Liu, Dou-Dou, Huang, Jie-Ying, Bai, Lu, Zhuang, Qing-Bin, Lu, Xiao-Ai, Zhang, Wei, Liu, Jing-Yu, Wang, Wu-Chun, Cao   +8 more
openaire   +2 more sources

Reactivation of Epstein-Barr virus in SFTSV infected patients

Infectious Medicine, 2023
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging hemorrhagic fever caused by a tick-borne bunyavirus SFTSV with case fatality up to 30%. The reactivation of Epstein-Barr virus (EBV) has been proven to occur in individuals with various immune suppression conditions.Here, we diagnosed 22 SFTSV infected patients with PCR in a hospital in ...
Li-Zhu Fang, Yu-Hong Dong, Zhi-Jian Yan, Chuan-Min Zhou, Xue-Jie Yu, Xiang-Rong Qin   +5 more
openaire   +3 more sources