Results 11 to 20 of about 3,280 (212)

Antibody production and characterization of the nucleoprotein of sever fever with thrombocytopenia syndrome virus (SFTSV) for effective diagnosis of SFTSV

Virology Journal, 2023
Background Severe fever with thrombocytopenia syndrome (SFTS) is an infectious disease caused by the Dabie bandavirus, [or SFTS virus (SFTSV)] that has become increasingly widespread since it was first reported in 2009.
Kyungha Lee, Min Ji Choi, Man-Ho Cho, Dong Ok Choi, Seong-Hee Bhoo   +4 more
doaj   +4 more sources

SFTSV infection in rodents and their ectoparasitic chiggers

PLoS Neglected Tropical Diseases, 2022
SFTSV, a tick-borne bunyavirus causing a severe hemorrhagic fever termed as severe fever with thrombocytopenia syndrome (SFTS). To evaluate the potential role of rodents and its ectoparasitic chiggers in the transmission of SFTSV, we collected wild ...
Xiao-Lan Gu, Wen-Qing Su, Chuan-Min Zhou, Li-Zhu Fang, Ke Zhu, Dong-Qiang Ma, Fa-Chun Jiang, Ze-Min Li, Dan Li, Shu-Hui Duan, Qiu-Ming Peng, Rui Wang, Yuan Jiang, Hui-Ju Han, Xue-Jie Yu   +14 more
doaj   +5 more sources

The Cap-Snatching SFTSV Endonuclease Domain Is an Antiviral Target [PDF]

Cell Reports, 2020
Severe fever with thrombocytopenia syndrome virus (SFTSV) is a tick-borne virus with 12%-30% case mortality rates and is related to the Heartland virus (HRTV) identified in the United States. Together, SFTSV and HRTV are emerging segmented, negative-sense RNA viral (sNSV) pathogens with potential global health impact.
Wang, Wenjie, Shin, Woo-Jin, Zhang, Bojie, Choi, Younho, Yoo, Ji-Seung, Zimmerman, Maxwell I, Frederick, Thomas E, Bowman, Gregory R, Gross, Michael L, Leung, Daisy W, Jung, Jae U, Amarasinghe, Gaya K   +11 more
openaire   +6 more sources

Bunyavirus SFTSV exploits autophagic flux for viral assembly and egress [PDF]

Autophagy, 2021
Severe fever with thrombocytopenia syndrome virus (SFTSV) is an emerging negatively stranded enveloped RNA bunyavirus that causes SFTS with a high case fatality rate of up to 30%. Macroautophagy/autophagy is an evolutionarily conserved process involved in the maintenance of host homeostasis, which exhibits anti-viral or pro-viral responses in reaction ...
Yan, Jia-min, Zhang, Wen-kang, Yan, Li-na, Jiao, Yong-Jun, Zhou, Chuan-min, Yu, Xue-jie   +5 more
openaire   +3 more sources

SFTSV Prevalence in Ticks and Livestock in an SFTSV-Endemic Area in Central China

Pathogens
Severe fever with thrombocytopenia syndrome virus (SFTSV) is an emerging tick-borne bunyavirus that causes a severe viral hemorrhagic fever (SFTS), with a very high case mortality rate, expanding epidemic areas, and increasing incidence. Due to the lack of an effective drug or vaccine for SFTS, reducing the incidence and mortality of SFTS primarily ...
Hui-Ya Lu, Guan-Du Wu, Meng Peng, Li-Bang Wu, Yi-Ming Luo, Bin Xia, Dan Xiong, Xiang-Rong Qin, Fang Guo, Xue-Jie Yu   +9 more
openaire   +3 more sources

Pre-existing immunity to heartland virus protects rhesus macaques from challenge with severe fever with thrombocytopenia syndrome virus [PDF]

Emerging Microbes and Infections
Heartland virus (HRTV) and Severe fever with thrombocytopenia syndrome virus (SFTSV) are closely related phenuiviruses that cause similar diseases in humans. However, animal disease models for both viruses are limited. Here, we first investigated whether
Thomas Bisom, Trenton Bushmaker, Natalie McCarthy, Jamie Lovaglio, Chad S. Clancy, Carl Shaia, Heinz Feldmann, David W. Hawman   +7 more
doaj   +2 more sources

Immune Cells at the Frontline of SFTSV Infection. [PDF]

J Microbiol Biotechnol
Severe fever with thrombocytopenia syndrome virus (SFTSV) is an emerging tick-borne Dabie bandavirus that causes hemorrhagic fever with high case fatality. Although numerous studies have examined specific aspects of SFTSV infection, an integrated framework that links viral immune cell tropism to immunopathogenesis remains lacking.
Park S, Kim C.
europepmc   +4 more sources

Investigation into the Pancreatic Pathogenesis of SFTSV across Multiple Levels

Advanced Science, Volume 13, Issue 1, 5 January 2026.
A retrospective analysis revealed that 17.6% of severe fever with thrombocytopenia syndrome (SFTS) patients met the diagnostic criteria for clinically confirmed pancreatitis. Using human pancreatic organoids and murine models demonstrated that SFTSV exhibits a specific pancreatic tropism, leading to cell death and initiating a strong inflammatory ...
Xiaohan Liu, Zhihao Xu, Yilun Tong, Changtai Wang, Yueqi Yao, Yujie Diao, Jingyuan Ma, Shijun Zhou, Yinan Du, Zhenhua Zhang, Gang Xu   +10 more
wiley   +4 more sources

Genome-wide CRISPR screening identifies LRP1 as an entry factor for SFTSV

Nature Communications
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging tick-borne disease caused by the SFTS virus (SFTSV), which has high mortality rates and poses a significant threat to public health. To identify potential therapeutic targets against SFTSV, we conduct genome-wide knockout screening, which identifies the previously known host factor CCR2,
Chen Xing, Cong Zhang, Zhihao Xu, Yajie Wang, Wanqing Lu, Xiaohan Liu, Yingying Zhang, Jingyuan Ma, Shuqi Yang, Yinan Du, Gang Xu, Yan Liu   +11 more
openaire   +4 more sources

Molecular mechanism and structure-guided humanization of a broadly neutralizing antibody against SFTSV.

PLoS Pathogens
Severe fever with thrombocytopenia syndrome virus (SFTSV) is a novel tick-borne bunyavirus that causes severe fever with thrombocytopenia syndrome (SFTS), with a high mortality rate of up to 30%.
Pinyi Yang, Xiaoli Wu, Hang Shang, Zixian Sun, Zhiying Wang, Zidan Song, Hong Yuan, Fei Deng, Shu Shen, Yu Guo, Nan Zhang   +10 more
doaj   +2 more sources