Results 11 to 20 of about 2,383 (169)

Antibody production and characterization of the nucleoprotein of sever fever with thrombocytopenia syndrome virus (SFTSV) for effective diagnosis of SFTSV

Virology Journal, 2023
Background Severe fever with thrombocytopenia syndrome (SFTS) is an infectious disease caused by the Dabie bandavirus, [or SFTS virus (SFTSV)] that has become increasingly widespread since it was first reported in 2009.
Kyungha Lee, Min Ji Choi, Man-Ho Cho, Dong Ok Choi, Seong-Hee Bhoo   +4 more
doaj   +3 more sources

Investigation into the Pancreatic Pathogenesis of SFTSV across Multiple Levels. [PDF]

Adv Sci (Weinh)
A retrospective analysis revealed that 17.6% of severe fever with thrombocytopenia syndrome (SFTS) patients met the diagnostic criteria for clinically confirmed pancreatitis. Using human pancreatic organoids and murine models demonstrated that SFTSV exhibits a specific pancreatic tropism, leading to cell death and initiating a strong inflammatory ...
Liu X, Xu Z, Tong Y, Wang C, Yao Y, Diao Y, Ma J, Zhou S, Du Y, Zhang Z, Xu G.   +10 more
europepmc   +5 more sources

Immune Cells at the Frontline of SFTSV Infection. [PDF]

J Microbiol Biotechnol
Severe fever with thrombocytopenia syndrome virus (SFTSV) is an emerging tick-borne Dabie bandavirus that causes hemorrhagic fever with high case fatality. Although numerous studies have examined specific aspects of SFTSV infection, an integrated framework that links viral immune cell tropism to immunopathogenesis remains lacking.
Park S, Kim C.
europepmc   +3 more sources

A humanized NOG-EXL mouse model for producing severe fever with thrombocytopenia syndrome virus-reactive human antibodies. [PDF]

Animal Model Exp Med
Humanized mouse models are essential for studying human immune response and antibody development. However, conventional models exhibit limited B cell maturation and antigen‐specific humoral responses. To overcome these limitations, we used the NOG‐EXL mice expressing human interleukin 3 (IL‐3) and granulocyte‐macrophage colony‐stimulating factor (GM ...
Lee DH, Bae J, Kim S, Song CY, Shin JH, Kim EH, Jang CH, Yun YS, Lee DS, Chu H, Choi JH, Kim CW.   +11 more
europepmc   +2 more sources

Genetic evolution and codon usage mode of SFTSV. [PDF]

Front Microbiol
Introduction Severe fever with thrombocytopenia syndrome virus (SFTSV), first identified in Henan Province, China (2009), has since been detected in 26 Chinese provinces and remains a significant public health threat.
Zhang Y, Hu L, Li C, Wei X, Shen Y, Li H, Sai L, Song L, Xu Y.   +8 more
europepmc   +3 more sources

<i>Bandavirus dabieense</i> Isolated From a Wild Leopard Cat (<i>Prionailurus bengalensis euptilura</i>) in the Republic of Korea. [PDF]

Transbound Emerg Dis
Bandavirus dabieense severe fever with thrombocytopenia syndrome virus (SFTSV) is an emerging tick‐borne zoonotic virus that causes severe febrile illness and high fatality rates in people. SFTSV is endemic to East Asia, notably in the Republic of Korea (ROK), Japan, and China.
Byun HR, Chae SJ, Ji SR, Shin HS, Kang JG, Jeong H, Lee S, Chae JS.   +7 more
europepmc   +2 more sources

The Cap-Snatching SFTSV Endonuclease Domain Is an Antiviral Target [PDF]

Cell Reports, 2020
Severe fever with thrombocytopenia syndrome virus (SFTSV) is a tick-borne virus with 12%-30% case mortality rates and is related to the Heartland virus (HRTV) identified in the United States. Together, SFTSV and HRTV are emerging segmented, negative-sense RNA viral (sNSV) pathogens with potential global health impact.
Wang, Wenjie, Shin, Woo-Jin, Zhang, Bojie, Choi, Younho, Yoo, Ji-Seung, Zimmerman, Maxwell I, Frederick, Thomas E, Bowman, Gregory R, Gross, Michael L, Leung, Daisy W, Jung, Jae U, Amarasinghe, Gaya K   +11 more
openaire   +4 more sources

Hedgehogs as Amplifying Hosts of Severe Fever with Thrombocytopenia Syndrome Virus, China

Emerging Infectious Diseases, 2022
Severe fever with thrombocytopenia syndrome virus (SFTSV) is a tickborne bandavirus mainly transmitted by Haemaphysalis longicornis ticks in East Asia, mostly in rural areas.
Chaoyue Zhao, Xing Zhang, Xiaoxi Si, Ling Ye, Kevin Lawrence, Yajun Lu, Chunhong Du, Haidong Xu, Qian Yang, Qianfeng Xia, Guoxiang Yu, Wei Xu, Fei Yuan, Junfeng Hao, Jia-Fu Jiang, Aihua Zheng   +15 more
doaj   +1 more source

Immunization with Recombinant SFTSV/NSs Protein Does Not Promote Virus Clearance in SFTSV-Infected C57BL/6J Mice [PDF]

Viral Immunology, 2015
The severe fever with thrombocytopenia syndrome (SFTS), caused by a novel Phlebovirus in the Bunyaviridae family named SFTS virus (SFTSV), is an emerging hemorrhagic fever with a wide distribution and high case-fatality rate. Neither effective treatment nor vaccines are available to treat and prevent this disease to date.
Rong, Liu, Dou-Dou, Huang, Jie-Ying, Bai, Lu, Zhuang, Qing-Bin, Lu, Xiao-Ai, Zhang, Wei, Liu, Jing-Yu, Wang, Wu-Chun, Cao   +8 more
openaire   +2 more sources

Bunyavirus SFTSV exploits autophagic flux for viral assembly and egress [PDF]

Autophagy, 2021
Severe fever with thrombocytopenia syndrome virus (SFTSV) is an emerging negatively stranded enveloped RNA bunyavirus that causes SFTS with a high case fatality rate of up to 30%. Macroautophagy/autophagy is an evolutionarily conserved process involved in the maintenance of host homeostasis, which exhibits anti-viral or pro-viral responses in reaction ...
Yan, Jia-min, Zhang, Wen-kang, Yan, Li-na, Jiao, Yong-Jun, Zhou, Chuan-min, Yu, Xue-jie   +5 more
openaire   +2 more sources