Results 21 to 30 of about 2,383 (169)

Construction and Characterization of Severe Fever with Thrombocytopenia Syndrome Virus with a Fluorescent Reporter for Antiviral Drug Screening

Viruses, 2023
Severe fever with thrombocytopenia syndrome (SFTS) caused by a novel bunyavirus (SFTSV) is an emerging infectious disease with up to 30% case fatality. Currently, there are no specific antiviral drugs or vaccines for SFTS. Here, we constructed a reporter
Xiao Wang, Mingyue Xu, Huanhuan Ke, Longda Ma, Liushuai Li, Jiang Li, Fei Deng, Manli Wang, Zhihong Hu, Jia Liu   +9 more
doaj   +1 more source

Severe fever with thrombocytopenia syndrome virus induces platelet activation and apoptosis via a reactive oxygen species-dependent pathway

Redox Biology, 2023
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging tick-borne infectious disease caused by the SFTS virus (SFTSV) and with a high fatality rate.
Yi-Hui Li, Xue-Hui Wang, Wen-Wu Huang, Ren-Rong Tian, Wei Pang, Yong-Tang Zheng   +5 more
doaj   +1 more source

Reactivation of Epstein-Barr virus in SFTSV infected patients

Infectious Medicine, 2023
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging hemorrhagic fever caused by a tick-borne bunyavirus SFTSV with case fatality up to 30%. The reactivation of Epstein-Barr virus (EBV) has been proven to occur in individuals with various immune suppression conditions.Here, we diagnosed 22 SFTSV infected patients with PCR in a hospital in ...
Li-Zhu Fang, Yu-Hong Dong, Zhi-Jian Yan, Chuan-Min Zhou, Xue-Jie Yu, Xiang-Rong Qin   +5 more
openaire   +3 more sources

Infection of humanized mice with a novel phlebovirus presented pathogenic features of severe fever with thrombocytopenia syndrome.

PLoS Pathogens, 2021
Severe fever with thrombocytopenia syndrome virus (SFTSV) is a tick-borne emerging phlebovirus with high mortality rates of 6.0 to 30%. SFTSV infection is characterized by high fever, thrombocytopenia, leukopenia, hemorrhage and multiple organ failures ...
Shijie Xu, Na Jiang, Waqas Nawaz, Bingxin Liu, Fang Zhang, Ye Liu, Xilin Wu, Zhiwei Wu   +7 more
doaj   +1 more source

Ultra-rapid detection of nuclear protein of severe fever with thrombocytopenia syndrome virus by colloidal gold immunochromatography assay [PDF]

PeerJ
In 2009, severe fever with thrombocytopenia syndrome virus (SFTSV), also known as the Dabie bandavirus (DBV), was first discovered in Henan, China. It is a tick-borne zoonotic virus with a fatality rate ranging from 6% to 30%. Currently, we lack safe and
Zhiwei Huang, Jianhua Li, Wentao Wei, Hongyu Li, Hao Yan, Ruyi Chen, Jiaxuan Li, Xiaotian Tie, Di Wang, Guangshang Wu, Ling Zhang, Yanjun Zhang, Keda Chen, Yongliang Lou   +13 more
doaj   +2 more sources

Knockout of CLTC gene reduces but not completely block SFTSV infection

PLOS ONE, 2023
Clathrin is a key protein for viruses to enter host cells. Previous studies often use clathrin inhibitors or gene knockdown technology to partially inhibit the function of clathrin, but whether SFTSV can infect host cells without clathrin expression remains unclear.
Tiezhu Liu, Jiajia Li, Xueqi Wang, Tao Huang, Wei Wu, Aqian Li, Chuan Li, Xiaoxia Huang, Qin Wang, Dexin Li, Shiwen Wang, Mifang Liang   +11 more
openaire   +3 more sources

Characterization of severe fever with thrombocytopenia syndrome in rural regions of Zhejiang, China. [PDF]

PLoS ONE, 2014
Severe fever with thrombocytopenia syndrome virus (SFTSV) infections have recently been found in rural regions of Zhejiang. A severe fever with thrombocytopenia syndrome (SFTS) surveillance and sero-epidemiological investigation was conducted in the ...
Lei Zhang, Ling Ye, David M Ojcius, Xiuyu Lou, Chengwei Wang, Cen feng, Yi Sun, Zhongfa Wang, Shibo Li, Yanjun Zhang   +9 more
doaj   +1 more source

Detection of SFTS virus RNA and antibodies in severe fever with thrombocytopenia syndrome surveillance cases in endemic areas of China

BMC Infectious Diseases, 2019
Background Severe fever with thrombocytopenia syndrome (SFTS) is a newly identified severe infectious disease caused by SFTS phlebovirus (SFTSV). SFTS monitoring has been carried out since 2010 in mainland China.
Xiaoxia Huang, Shujun Ding, Xiaolin Jiang, Bo Pang, Quanfu Zhang, Chuan Li, Aqian Li, Jiandong Li, Mifang Liang, Shiwen Wang, Dexin Li   +10 more
doaj   +1 more source

SFTSV Infection Induced Interleukin-1β Secretion Through NLRP3 Inflammasome Activation

Frontiers in Immunology, 2021
Severe fever with thrombocytopenia syndrome virus (SFTSV) is an emerging tick-borne virus that causes hemorrhagic fever. Previous studies showed that SFTSV-infected patients exhibited elevated levels of pro-inflammatory cytokines like interleukin-1β (IL ...
Jian-Wei Liu, Min Chu, Yong-jun Jiao, Chuan-Min Zhou, Rui Qi, Xue-jie Yu   +5 more
doaj   +1 more source

Fine mapping epitope on Glycoprotein-Gn from Severe Fever with Thrombocytopenia Syndrome Virus.

PLoS ONE, 2021
Severe Fever with Thrombocytopenia Syndrome Virus (SFTSV) was recently identified as a tick-borne pathogen that threat to human health. Since 2010, many countries including China, South Korea, and Japan have reported Human SFTS caused by SFTSV infection.
Abulimiti Moming, Shen Shi, Shu Shen, Jie Qiao, Xihong Yue, Bo Wang, Juntao Ding, Zhihong Hu, Fei Deng, Yujiang Zhang, Surong Sun   +10 more
doaj   +1 more source