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Abstract SGLT2 inhibitors were first introduced for heart failure in 2020 and are now first-line agents for all patients with symptomatic heart failure regardless of left ventricular ejection fraction. They reduce both morbidity and mortality in clinical trials with an average relative risk reduction of 23% for heart failure ...
Roy S. Gardner +3 more
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Roy S. Gardner +3 more
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Current Opinion in Cardiology, 2018
To address common concerns regarding sodium-glucose cotransporter 2 (SGLT2) inhibitor use for patients with type 2 diabetes mellitus (T2DM) in cardiovascular practice.SGLT2 inhibitors provide glycemic control and improve cardiovascular and renal endpoints in T2DM.
Erika, Opingari +3 more
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To address common concerns regarding sodium-glucose cotransporter 2 (SGLT2) inhibitor use for patients with type 2 diabetes mellitus (T2DM) in cardiovascular practice.SGLT2 inhibitors provide glycemic control and improve cardiovascular and renal endpoints in T2DM.
Erika, Opingari +3 more
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Journal of the American College of Cardiology, 2021
Richard K. Cheng +5 more
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Richard K. Cheng +5 more
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Nihon rinsho. Japanese journal of clinical medicine, 2016
SGLT2 is a glucose transporter which plays an important role for reabsorption of urinary glucose depending on the sodium concentration gradient. SGLT2 is mainly present in apical site of S1 segment of renal proximal tubule and accounts for approximately 90% of total urinary glucose reabsorption. SLC5a2, which codes SGLT2, is also known as the causative
Naoto, Kubota, Takashi, Kadowaki
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SGLT2 is a glucose transporter which plays an important role for reabsorption of urinary glucose depending on the sodium concentration gradient. SGLT2 is mainly present in apical site of S1 segment of renal proximal tubule and accounts for approximately 90% of total urinary glucose reabsorption. SLC5a2, which codes SGLT2, is also known as the causative
Naoto, Kubota, Takashi, Kadowaki
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Gliflozin (
AbstractIntroductionSodium‐glucose co‐transporter 2 (SGLT2) inhibitors, or gliflozins, are used as mono or combined therapy in the management of diabetes. Genital infections are the most common reported adverse effect, as a result of induced glycosuria.
Stephen J. Mounsey +3 more
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SGLT2 Inhibitors: Benefit/Risk Balance
Current Diabetes Reports, 2016Inhibitors of sodium-glucose cotransporters type 2 (SGLT2) reduce hyperglycemia by increasing urinary glucose excretion. They have been evaluated in patients with type 2 diabetes treated with diet/exercise, metformin, dual oral therapy or insulin. Three agents are available in Europe and the USA (canagliflozin, dapagliflozin, empagliflozin) and others ...
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SGLT2 inhibitors: new reports.
The Medical letter on drugs and therapeutics, 2016A significant decrease in cardiovascular mortality has been reported with use of the SGLT2 inhibitor empagliflozin (Jardiance) to treat patients with type 2 diabetes who have established cardiovascular disease. The mechanism of this reduction is unclear, and these results may not apply to patients with type 2 diabetes and less advanced cardiovascular ...
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SGLT2 Inhibitors in Diabetes Mellitus Treatment
Reviews on Recent Clinical Trials, 2017Type 2 Diabetes Mellitus (T2DM) is a chronic illness with high prevalence in Mexico, Latin- America, and the world and is associated to high morbidity, disability, and mortality rate, especially in developing countries. T2DM physiopathology is very complex; insulin resistance in the muscle, liver, and adipose tissue, a reduction in the production of ...
Juan, Rosas-Guzman +2 more
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Discovery of non-glucoside SGLT2 inhibitors
Bioorganic & Medicinal Chemistry Letters, 2011A series of benzothiazinone and benzooxazinone derivatives were discovered as SGLT2 inhibitors. The optimization led to the discovery of compounds 31 and 32, which exhibited similar potency and better SGLT1 selectivity compared to dapagliflozin. These compounds may provide novel promising scaffolds, which are different from phlorizin-based SGLT2 ...
An-Rong, Li +4 more
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SGLT2 inhibitors may prevent diabetes
Nature Reviews Nephrology, 2022Daniel V. O’Hara, Meg J. Jardine
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