Results 71 to 80 of about 29,954 (261)

A Mixed Property-Based Automatic Shadow Detection Approach for VHR Multispectral Remote Sensing Images

open access: yesApplied Sciences, 2018
Shadows in very high-resolution multispectral remote sensing images hinder many applications, such as change detection, target recognition, and image classification.
Hongyin Han   +7 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

open access: yesMolecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu   +13 more
wiley   +1 more source

RenDetNet: Weakly-Supervised Shadow Detection with Shadow Caster Verification

open access: yes
Existing shadow detection models struggle to differentiate dark image areas from shadows. In this paper, we tackle this issue by verifying that all detected shadows are real, i.e. they have paired shadow casters. We perform this step in a physically-accurate manner by differentiably re-rendering the scene and observing the changes stemming from carving
Nikolina Kubiak   +5 more
openaire   +2 more sources

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

open access: yesMolecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski   +10 more
wiley   +1 more source

Shadow Spatiotemporal Track-Before-Detect Approach for Distributed UAV-Borne Video SAR

open access: yesRemote Sensing
Shadow detection has become a key technology for ground-based moving target indication in video synthetic aperture radar (SAR). However, single-platform video SAR faces the issue of moving-target shadows being occluded.
Liwu Wen   +4 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola   +11 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

Shadow Detection in Remote Sensing Images Based on Multibranch Feature Aggregation and Channel-Spatial Attention

open access: yesIEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing
High-resolution remote sensing image shadow detection has wide applications in target recognition, land information retrieval, and other fields.
Xueli Chang   +4 more
doaj   +1 more source

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