Results 81 to 90 of about 2,939,416 (298)
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Image Shadow Detection and Removal Based on Region Matching of Intelligent Computing. [PDF]
Comput Intell Neurosci, 2022 Feng J, Kim YK, Liu P.
europepmc +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
RenDetNet: Weakly-Supervised Shadow Detection with Shadow Caster Verification
Existing shadow detection models struggle to differentiate dark image areas from shadows. In this paper, we tackle this issue by verifying that all detected shadows are real, i.e. they have paired shadow casters. We perform this step in a physically-accurate manner by differentiably re-rendering the scene and observing the changes stemming from carving
Nikolina Kubiak +5 more
openaire +2 more sources
Fire Detection And 3D Fire Propagation Estimation For The Protection Of Cultural Heritage Areas [PDF]
, 2010 Beyond taking precautionary measures to avoid a forest fire, early warning and immediate response to a fire breakout are the only ways to avoid great losses and environmental and cultural heritage damages.
Grammalidis, N. +8 more
core
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Shadow Spatiotemporal Track-Before-Detect Approach for Distributed UAV-Borne Video SAR
Remote SensingShadow detection has become a key technology for ground-based moving target indication in video synthetic aperture radar (SAR). However, single-platform video SAR faces the issue of moving-target shadows being occluded.
Liwu Wen +4 more
doaj +1 more source
Decentralization and the Shadow Economy: Oates Meets Allingham-Sandmo [PDF]
This paper studies the impact of decentralization on the shadow economy. We argue that decentralization may decrease the size of the shadow economy mainly through two transmission channels: (1) Decentralization enhancing public sector efficiency ...
Andreas Bühn +2 more
core
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source