Results 51 to 60 of about 429,033 (302)

Assessing concept possession as an explicit and social practice [PDF]

, 2017
We focus on issues of learning assessment from the point of view of an investigation of philosophical elements in teaching. We contend that assessment of concept possession at school based on ordinary multiple-choice tests might be ineffective because it
Marabini, Alessia, Moretti, Luca
core   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Worldwide Shadow Education Epidemic and Its Move toward Shadow Curriculum

Journal of Language Teaching and Research, 2020
Shadow education has become a widespread phenomenon worldwide and is now an unavoidable learning space for many students. It challenges the traditional notion of factory-like one-size-fits-all education and provides students with more personalized learning.
Yaghoob Javadi, Fakhereh Kazemirad
openaire   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Shadow writing and participant observation : a study of criminal justice social work around sentencing [PDF]

, 2008
The study of decision-making by public officials in administrative settings has been a mainstay of law and society scholarship for decades. The methodological challenges posed by this research agenda are well understood: how can socio-legal researchers ...
Burns, Nicola, Halliday, Simon, Hutton, Neil, McNeil, F., Tata, Cyrus   +4 more
core   +1 more source

P156: Exploring educational innovation: out of the shadows of shadow week [PDF]

CJEM, 2018
Introduction: In the third year of medical school, students participate in a four week period called Transition to Clerkship, followed by Shadow week, where students spend one week in the discipline prior to starting clerkship. In the past, students have identified that receiving specific additional training during Shadow week would help them succeed ...
T. Wawrykow, H. Mawdsley
openaire   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

A group of primary four students' perceptions on shadow education and how it contributes to their English language learning [PDF]

, 2014
This qualitative study was conducted to investigate a group of primary four students' perceptions on shadow education, examine how some elements of shadow education influence students' learning of the English subject, and explore pedagogical implications
Cheung, Tsz-ling, 張紫鈴
core  

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

AGRICULTURAL PRODUCTIVITY AND OFF-FARM LABOR DECISIONS BY HEADS AND SPOUSES IN NICARAGUA: A SEMIPARAMETRIC ANALYSIS USING PANEL DATA [PDF]

, 2011
The objective of this paper is to analyze the determinants of off-farm labor supply by heads of household and their spouses in Nicaragua. Using a three-year balanced panel dataset, we refine the approach introduced by Jacoby (1993) and Skoufias (1994) to
Almeida, Alex, Bravo-Ureta, Boris
core