Results 51 to 60 of about 19,580 (259)

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Shadow education in Latin America: Assembling the jigsaw

Revista Española de Pedagogía
Shadow education is a widely used metaphor for private supplementary tutoring, i.e. instruction in academic subjects on a fee-charging basis outside school hours. The metaphor is used because much tutoring mimics schooling.
Mark Bray, Alexandre Ventura
doaj   +1 more source

Shadow Education as Sociological Field

, 2023
Research on curriculum and shadow education (also known as private or supplementary tutoring) is increasing and diversifying. Shadow education can be understood as out-of-school formal education. Although separate from the school program, it is directed toward that program. Shadow education often targets aspects of the curriculum of mass schooling that
openaire   +2 more sources

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

AI literacy in shadow education: exploring Chinese EFL practitioners’ perceptions and experiences

Journal of China Computer-Assisted Language Learning
Artificial intelligence (AI) is increasingly reshaping education by identifying students’ learning challenges and enhancing academic performance. However, many teachers lack a comprehensive understanding of AI, limiting their ability to fully utilise its
Liu Qian, Jiang Mengjie, Wang Yonghua (Yoka), He Liqun   +3 more
doaj   +1 more source

Comment les enseignants perçoivent-ils l’efficacité du tutorat privé en Malaisie ?

Revue Internationale d’Éducation de Sèvres, 2014
Cet article examine la façon dont les enseignants perçoivent l’efficacité du tutorat privé en Malaisie. Se fondant sur des données provenant de trois États – Perak, Selangor et Wilayah Persekutuan – les conclusions suggèrent que les enseignants ...
Husaina Banu Kenayathulla
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Participation in Shadow Education in Church- and State-Maintained Schools: The Role of Cultural and Social Capital

Central European Journal of Educational Research
Research on shadow education is often justified based on Bourdieu’s theory of capital as it is assumed to contribute to social inequalities. This paper focuses on the role of cultural and social capital and on the differences between state- and church ...
Gabriella Hegedűs, Ildikó Csépes
doaj   +1 more source

Researching shadow education: methodological challenges and directions [PDF]

Asia Pacific Education Review, 2010
Research on shadow education has considerably increased in volume and has helped to improve understanding of the scale, nature, and implications of the phenomenon. However, the field is still in its infancy. Literature on shadow education reflects confusion over terms and parameters, and data suffer from challenges in securing evidence from actors who ...
openaire   +3 more sources