Results 61 to 70 of about 1,214,646 (321)

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

open access: yesFEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman   +2 more
wiley   +1 more source

STATISTICAL ESTIMATION OF UNOBSERVED ECONOMIC ACTIVITY

open access: yesВестник Российского экономического университета имени Г. В. Плеханова, 2017
The article researches methods of measuring unobserved economy. The methods being analyzed are based on statistics of households, the method of factual employment, expert method, etc.
Galina V. Agentova
doaj   +1 more source

Corruption in business: motives and influence on shadow economy

open access: yesBusiness: Theory and Practice, 2023
The paper devoted to the research of the corruption offenses in the activity of business entities which are quite a common phenomenon that causes serious moral, economic and political problems, hinders development and distorts fair competition.
Tetiana Momot   +4 more
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

DEVELOPMENT OF THE SELF-EMPLOYED SECTOR: CONDITIONS AND PROSPECTS

open access: yesВестник Пермского университета: Серия Экономика, 2022
These days, the sector of small and medium-sized entrepreneurship targets a number of key concerns of territories’ economic development. This is due to both external challenges associated with tougher economic sanctions and national issues, in particular
Svetlana Viktorovna Terebova   +2 more
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

Labor Institutions and their Impact on Shadow Economies in Europe [PDF]

open access: yes
This paper analyzes the role of labor market institutions in explaining developments of shadow economies in European countries. We use several alternative measures of the shadow sector, and we examine effects of labor institutions on shadow sector in two
Kamila Fialová
core   +4 more sources

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Active Ageing and Shadow Economy in Romania. An Empirical Causality Analysis

open access: yesManagement Dynamics in the Knowledge Economy, 2015
The paper aims to analyze the unidirectional relationship from active ageing phenomena to the size of the Romanian shadow economy in order to see if the unofficial sector represents a social buffer for older workers who have lower labor market ...
Adriana AnaMaria DAVIDESCU
doaj  

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

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