Results 41 to 50 of about 8,554 (295)

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Mission oriented approach to achieving employment and career goals

, 2021
Video training series for veterans to learn a mission-oriented approach to occupational and career goals.Episode 1 - Introduction and general readiness -- Episode 2 - Translating military speak -- Episode 3 - Cover letters -- Episode 4 - Functional ...

core  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Labor Institutions and their Impact on Shadow Economies in Europe [PDF]

This paper analyzes the role of labor market institutions in explaining developments of shadow economies in European countries. We use several alternative measures of the shadow sector, and we examine effects of labor institutions on shadow sector in two
Kamila Fialová
core   +1 more source

Assessment of shadow employment in the agricultural sector

The Economy under Guard
Shadow employment in agriculture is a widespread phenomenon not only in developing countries, but also in countries with an established market. Based on statistical data, the article analyzes the current situation of informal employment in the agricultural industry, suggests possible ways to solve the problem, including improving fiscal regulation ...
Tat'yana Agapova, Alina Soboleva
openaire   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

STATISTICAL ESTIMATION OF UNOBSERVED ECONOMIC ACTIVITY

Вестник Российского экономического университета имени Г. В. Плеханова, 2017
The article researches methods of measuring unobserved economy. The methods being analyzed are based on statistics of households, the method of factual employment, expert method, etc.
Galina V. Agentova
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Shadow Sorting [PDF]

This paper investigates the border between formal employment, shadow employment, and unemployment in an equilibrium model of the labor market with market frictions.
Tito Boeri, Pietro Garibaldi
core   +1 more source

Active Ageing and Shadow Economy in Romania. An Empirical Causality Analysis

Management Dynamics in the Knowledge Economy, 2015
The paper aims to analyze the unidirectional relationship from active ageing phenomena to the size of the Romanian shadow economy in order to see if the unofficial sector represents a social buffer for older workers who have lower labor market ...
Adriana AnaMaria DAVIDESCU
doaj