Results 51 to 60 of about 6,283 (255)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
STATISTICAL ESTIMATION OF UNOBSERVED ECONOMIC ACTIVITY
Вестник Российского экономического университета имени Г. В. Плеханова, 2017 The article researches methods of measuring unobserved economy. The methods being analyzed are based on statistics of households, the method of factual employment, expert method, etc.
Galina V. Agentova
doaj +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Active Ageing and Shadow Economy in Romania. An Empirical Causality Analysis
Management Dynamics in the Knowledge Economy, 2015 The paper aims to analyze the unidirectional relationship from active ageing phenomena to the size of the Romanian shadow economy in order to see if the unofficial sector represents a social buffer for older workers who have lower labor market ...
Adriana AnaMaria DAVIDESCU
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Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
An analysis of the influence of shadow economy on economic development
Serbian Journal of ManagementThe shadow economy is an umbrella concept that covers different aspects of the informal economic sectors. Conventional wisdom states that an increased size of the shadow economy hampers economic growth.
Bogdan Dima +2 more
doaj +1 more source
KEDI Journal of Educational Policy, 2018 The purpose of this study is to examine whether the changes of the ‘college admission policy’ have affected students’ use of ‘shadow education’. Additionally, the study seeks to examine the relationship between ‘education fever’ in Korea and the policy ...
Soojeong Lee
doaj +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Self-employement and Informal Labor Market in Russia Самозанятость населения и теневой рынок труда в России [PDF]
Problemi Ekonomiki, 2012 The article deals with self-employment in Russia and its link with the informal labor market. The authors identified the main reasons for the low level of self-employment in Russia: the imperfect statistics, the high costs of the legal activities, the ...
Kireenko Anna P.,, Klimova Mariya O.
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