Results 61 to 70 of about 407,307 (292)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Adaptive Secret Sharing for Color Images [PDF]
International Journal of Computational Intelligence Systems, 2011 A secret sharing model can secure a secret over multiple noise-like shadows and remain recoverable despite multiple shadow failures. Even if some of the shadows are compromised, the secret will not be revealed as long as the number of the compromised ...
Jia-Hong Li +4 more
doaj +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
Dusty spirals triggered by shadows in transition discs
, 2018 Context. Despite the recent discovery of spiral-shaped features in protoplanetary discs in the near-infrared and millimetric wavelengths, there is still an active discussion to understand how they formed.
Cuadra, Jorge +4 more
core +1 more source
Social Neuroscience, 2006 The recent finding that Broca's area, the motor center for speech, is activated during action observation lends support to the idea that human language may have evolved from neural substrates already involved in gesture recognition. Although fascinating, this hypothesis can be questioned because while observing actions of others we may evoke some ...
FADIGA L +6 more
openaire +4 more sources
Robust tracking of multiple objects in video by adaptive fusion of subband particle filters
IET Computer Vision, 2018 Tracking of moving objects in video sequences is an important research problem because of its many industrial, biomedical, and security applications. Significant progress has been made on this topic in the last few decades.
Ahmed Mahmoud, Sherif S. Sherif
doaj +1 more source
Earthquakes in the Shadows: Why Aftershocks Occur at Surprising Locations
The Seismic Record, 2022 For decades there has been a debate about the relative effects of dynamic versus static stress triggering of aftershocks. According to the static Coulomb stress change hypothesis, aftershocks should not occur in stress shadows—regions where static ...
Jeanne L. Hardebeck, Ruth A. Harris
doaj +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source