Results 61 to 70 of about 49,092 (266)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

A hybrid temporal compositing algorithm for multispectral surface reflectance imagery

GIScience & Remote Sensing
Temporal compositing of optical satellite imagery is widely used to identify representative clear-sky observations and to reduce data volume. This paper introduces HybridTC, a hybrid temporal compositing algorithm developed for medium-resolution ...
Lixin Sun, Richard Fernandes, Junhua Li
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Extension and the Ground in Motion’s Gestalt: Literal and metaphoric

Gestalt Theory
We propose that in pictures both the extended limbs of actors and the ground are involved in gestalts for movement. Limbs extend to suggest more motion literally when a dancer is in air and refer to a canonical pose when on the ground.
Mastandrea Stefano, Kennedy John M.
doaj   +1 more source

Solar Drawings and Moving Shades: An Affective Aesthetics for the Urban Climatic Mutation

Diseña
In a world saturated with planetary images that compel but rarely mobilize, we turn to solar drawings as an affective aesthetics for climate action. How can drawing attune us to changing landscapes while supporting transdisciplinary inquiries?
Tomás Criado, Carla Boserman
doaj   +1 more source

The data shadow

ACM SIGCAS Computers and Society, 2017
This hypothetical story is about personal data which resides on the internet. It has its foundation in things which have happened. It raises serious questions about whether we should be more wary of, and whether there are things organisations and individuals could do to reduce the risks associated with data shadows.
openaire   +2 more sources

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Penumbra Shadow Representation in Photovoltaics: Comparing Dynamic and Constant Intensity

Applied Sciences
This study is the first to directly compare natural dynamic penumbra shadows with experimentally replicated constant-intensity shadows on photovoltaic modules, providing new insights into the limitations of conventional shadow approximations found in the
Matthew Axisa, Luciano Mule’ Stagno, Marija Demicoli   +2 more
doaj   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Economía global: FAR Frohn & Rojas

ARQ, 2012
Materialmente irrelevante (apenas 23 kg de espejos, focos LED y motores minúsculos), el proyecto de esta galería de sombras plantea preguntas sobre el uso de diferentes recursos, su escasez y su abundancia.Almost immaterial (mirrors, LED bulbs and tiny ...
Marc Frohn, Mario Rojas
doaj