Results 81 to 90 of about 407,307 (292)

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Penumbra Shadow Representation in Photovoltaics: Comparing Dynamic and Constant Intensity

Applied Sciences
This study is the first to directly compare natural dynamic penumbra shadows with experimentally replicated constant-intensity shadows on photovoltaic modules, providing new insights into the limitations of conventional shadow approximations found in the
Matthew Axisa, Luciano Mule’ Stagno, Marija Demicoli   +2 more
doaj   +1 more source

Single image shadow removal by optimization using non-shadow anchor values

Computational Visual Media, 2019
Shadow removal has evolved as a pre-processing step for various computer vision tasks. Several studies have been carried out over the past two decades to eliminate shadows from videos and images. Accurate shadow detection is an open problem because it is
Saritha Murali, V. K. Govindan, Saidalavi Kalady   +2 more
doaj   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Shadows and traces in bicategories

, 2012
Traces in symmetric monoidal categories are well-known and have many applications; for instance, their functoriality directly implies the Lefschetz fixed point theorem. However, for some applications, such as generalizations of the Lefschetz theorem, one
A Dold, A Hattori, A Joyal, A Joyal, A Joyal, A Ranicki, B Day, BJ Jiang, GM Kelly, J Stallings, JC Baez, JP May, JP May, PJ Freyd, R Street   +14 more
core   +1 more source

Perception of shadows in children with autism spectrum disorders.

PLoS ONE, 2010
BackgroundCast shadows in visual scenes can have profound effects on visual perception. Much as they are informative, they also constitute noise as they are salient features of the visual scene potentially interfering with the processing of other ...
Cristina Becchio, Morena Mari, Umberto Castiello   +2 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Review of The Long Shadows: A Global Environmental History of the Second World War by Simo Laakkonen, Richard P. Tucker, and Timo Vuorisalo, eds. [PDF]

, 2019
Review of The Long Shadows: A Global Environmental History of the Second World War by Simo Laakkonen, Richard P.
Souchen, Alex
core   +1 more source

Automatic Shadow Detection in Urban Very-High-Resolution Images Using Existing 3D Models for Free Training

Remote Sensing, 2019
Up-to-date 3D city models are needed for many applications. Very-high-resolution (VHR) images with rich geometric and spectral information and a high update rate are increasingly applied for the purpose of updating 3D models.
Kaixuan Zhou, Roderik Lindenbergh, Ben Gorte   +2 more
doaj   +1 more source