Results 91 to 100 of about 82,188 (311)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

open access: yesMolecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain   +10 more
wiley   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

open access: yesMolecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena   +15 more
wiley   +1 more source

Technical shadows [PDF]

open access: yes, 2018
Title: Technical shadows Author: Jana Vlčková Department: Departement of Mathematics Education Supervisor: RNDr. Jana Hromadová, Ph.D., Departement of Mathematics Education Abstract: This bachelor's thesis concerns with the topic of technical shadows ...
Vlčková, Jana
core  

Shadowing for Pronunciation Development : Haptic-Shadowing and IPA-Shadowing [PDF]

open access: yesThe Journal of AsiaTEFL, 2018
Shadowing was introduced to foreign language teaching in the 1990s and since then it has been researched in EFL teaching contexts. Shadowing has been used as a listening task, and its effectiveness on listening comprehension has been acknowledged. However, its effect on pronunciation development remains unclear.
openaire   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

open access: yesMolecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen   +9 more
wiley   +1 more source

Eggs, Purple Ivy Shadows, and Wimp Factor 14 concert fliers - HUB Ballroom, University Park, Pennsylvania, February 26, 1993

open access: yes, 1993
Two fliers advertising a concert by the Washington D.C. indie rock band Eggs. The concert occurred at the HUB Ballroom in University Park, Pennsylvania on February 26, 1993.

core  

Stylized shadows

open access: yes, 2007
Figure 1: Traditional computer graphics algorithms produce “accurate ” shadows (left). Artists often deliberately render abstract shadows, such as the shadow with reduced contour detail in this painting by Vanderlyn, 1818 (middle).
Christopher Decoro   +3 more
core   +1 more source

Asphalted Road Temperature Variations Due to Wind Turbine Cast Shadows

open access: yesSensors, 2009
The contribution of this paper is a technique that in certain circumstances allows one to avoid the removal of dynamic shadows in the visible spectrum making use of images in the infrared spectrum.
Jonay Toledo   +3 more
doaj   +1 more source

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

open access: yesMolecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou   +12 more
wiley   +1 more source

Some varieties of shadow illusions: split shadows, occluded shadows, stolen shadows, and shadows of shadows. Perception, 41, 357-360.

open access: yes, 2012
Shadows are visual objects and as such are subject to preference rules for segmenting the visual scene (such as Gestalt laws). These rules govern shadows along two dimensions: their general unity and individuation (e.g., they describe a certain area as a
Casati, Roberto
core   +1 more source

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