Results 51 to 60 of about 228,109 (316)
Systematic Approaches for Signal Processing of Soil Shaking Table Test
MATEC Web of Conferences, 2017 Selecting an appropriate methodology in signal processing of shaking table test is of fundamental importance for evaluating the soil dynamic parameters.
Lim Jun Xian, Lee Min Lee, Tanaka Yasuo
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A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
Molecular Oncology, EarlyView.This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker +16 more
wiley +1 more source
Advances in Real-Time Hybrid Testing Technology for Shaking Table Substructure Testing
Frontiers in Built Environment, 2020 Shaking table substructure testing (STST) takes the substructure with complex behavior physically tested, with the behavior of the rest structural system being numerically simulated.
Yingpeng Tian +3 more
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Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Dynamic Characteristics of Metro Tunnel Closely Parallel to a Ground Fissure
Complexity, 2019 Shaking table model test and numerical simulation model were conducted on scaled tunnel model to investigate the mechanism and effect of seismic loadings on metro tunnel which is closely parallel to an active ground fissure.
Nina Liu +6 more
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Shake table tests to compare the seismic response of concrete frames with conventional and high‐strength reinforcement [PDF]
, 2023 Chih‐Hsuan Chin +3 more
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Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Experiment program of shake table test on a precast frame made of recycled aggregate concrete
Ho Chi Minh City Open University Journal of Science - Engineering and Technology, 2016 A precast frame model made of Recycled Aggregate Concrete (RAC) been constructed with precast beams, columns and Cast-In-Place (CIP) joints. Then a shaking table test was carried out with three types of earthquake ground motions, namely Wenchuan, El ...
Pham Thi Loan, Phan Van Hue
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