Results 51 to 60 of about 21,924 (247)

Multi‐Targeting Carnosic Acid Kills Drug‐Resistant Helicobacter pylori With Narrow‐Spectrum Activity

Advanced Science, EarlyView.
Carnosic acid selectively eradicates drug‐resistant Helicobacter pylori through a multi‐targeted mechanism involving urease inhibition, membrane disruption, and biofilm eradication. It exhibits no detectable resistance, potent in vivo efficacy, and minimal impact on gut microbiota, positioning it as a promising narrow‐spectrum lead compound against ...
Yuefan Bai, Hongming Huang, Xudong Hang, Shanwei Hu, Qian Tong, Jingchen Xu, Jia Jia, Hongkai Bi   +7 more
wiley   +1 more source

180 Beyond Days of Therapy: The Anaerobic Activity Index (AAI) Strongly Correlates with Shannon Diversity and Pathogen Expansion

Antimicrobial Stewardship & Healthcare Epidemiology
Background: Carbapenem-resistant Acinetobacter baumannii (CRAB) is an opportunistic organism that can cause serious infections that are difficult to treat.
Megan Sutton, Grace Lee, Andrea Salinas, Ashley Marin   +3 more
doaj   +1 more source

Spatiotemporal analysis of urban growth on forest and agricultural land using geospatial techniques and Shannon entropy method in the satellite town of Ethiopia, the western fringe of Addis Ababa city

Ecological Processes, 2020
Rapid conversion of conserved land and cropland to non-agricultural purposes is threatening the ecological areas and dominant agricultural activities that are the main sources of livelihood in urban fringe areas of Addis Ababa City.
Kiros Tsegay Deribew
doaj   +1 more source

Conformational Snapshots of CydDC in a Native Lipid Bilayer Coupling Heme Transport to Antibiotic Resistance

Advanced Science, EarlyView.
Phylogenetic and biochemical analyses of the heme transporter CydDC reveal its functional conservation throughout bacterial evolution and demonstrate its unique asymmetric allosteric mechanism. Furthermore, impairment of CydDC function directly affects bacterial antibiotic resistance and likely compromises antibiotic efficacy through drug efflux.
Lili Yang, Changbin Zhang, Mengyuan Lyu, Yongbo Luo, Jierou Zhang, Yujiao Chen, Lintao Luo, Wen Qiao, Xiangyangpeng Li, Yu Zhou, Zhongling Wei, Yuling Xiao, Qian Niu, Juan Zhou, Guanglin He, Binwu Ying, Zhaoming Su, Hao Chen, Xiaodi Tang, Haohao Dong   +19 more
wiley   +1 more source

A Phase‐Resolved Geometric Deep Learning Framework Maps Structural Determinants of Disease‐Associated Protein Aggregation and Guides Suppressor Design

Advanced Science, EarlyView.
SKALE 2.0 maps disease‐associated protein aggregation as a phase‐resolved structural process, linking mutation‐induced geometric perturbations to nucleation, elongation, and suppressor design. Across neurodegenerative proteins, the framework reveals cryptic aggregation vulnerabilities, separates phase‐concordant and phase‐switching mutations, and ...
Jia Shen Sio, Wei Xuan Wilson Loo, Yan Shan Loo, Wen Xin Tan, Hui Xuan Lim, Huitao Liu, Chen Seng Ng   +6 more
wiley   +1 more source

A Single‐Cell Transcriptomic Atlas of the Ovine Rumen Microbiome Characterizes Lineage‐Specific Metabolic Shifts Associated with Host Heat Tolerance

Advanced Science, EarlyView.
An optimized single‐cell transcriptomic framework profiles over 60 000 cells to map the ovine rumen microbiome, partitioning the ecosystem into seven cross‐species functional clusters. In heat‐resistant hosts, a lineage‐specific metabolic shift in Anaerovibrio lipolyticus toward a highly glycolytic phenotype contributes to a “nutritional sparing ...
Sanbao Zhang, Qinyang Jiang, Junjie Ma, Jianwei Zou, Fan Wang, Feifei Lv, Yanna Huang, Yongcheng Wang, Ziye Xu   +8 more
wiley   +1 more source

Mosquito vectors of yellow fever virus in areas of epidemiological risk in northeastern Argentina

Ecología Austral
Due to several epizootic events between 2020 and 2021 in the south of Brazil near the border with Argentina, we performed mosquito surveys in areas of epidemiological risk in northeast Argentina to evaluate abundance and distributions of mosquito ...
Arturo A. Lizuain, Evangelina Muttis, Marina Leporace, María E. Cano, Soraya Acardi, Francisco Sánchez Gavier, Mahia M. Ayala, Melina V. Brividoro, Gerardo A. Marti, María V. Micieli, Mariana Manteca-Acosta   +10 more
doaj   +1 more source

Multi‐Component Functionalized Bifidobacterium Longum Hydrogel for Multi‐Target Integrated Therapy of Colitis‐Associated Anxiety and Depression

Advanced Science, EarlyView.
A pH/MMP dual‐responsive Bifidobacterium longum (BL) hydrogel (INPs@BL@Gel) functionalized with baicalin, tyrosine, and inulin is constructed. It enables gastric protection, inflammation‐targeted release, and prolonged intestinal colonization. By remodeling gut microbiota, elevating beneficial neuroactive metabolites (homovanillic acid, short‐chain ...
Shuo Zhang, Yujie Zhang, Jiansheng He, Shunlian Li, Qingyan Ma, Qiao Li, Yudan Zhang, Yiyang Wang, Shaobo Ma, Songyan Jin, Chune Li, Xueyong Xie, Hang Zhang, Junze Deng, Xueqin Song, Daocheng Wu, Xiancang Ma, Feng Zhu   +17 more
wiley   +1 more source

Intestinal dysbiosis in critically ill patients: a case–control study of Enterobacteriaceae enrichment and reduced microbial diversity

Frontiers in Medicine
IntroductionCritical illness disrupts gut microbiota homeostasis, potentially exacerbating systemic inflammation and adverse outcomes. This study investigates gut dysbiosis patterns in ICU patients, with a focus on Enterobacteriaceae enrichment and ...
Dan Wang, Jinman Li, Lei Wang, Heng Tian, Xuan Zhou, Xiaolei Wang, Huiyu Tian   +6 more
doaj   +1 more source

Effect of Didymosphenia geminata coverage on the phytobenthic community in an Andean basin of Chile

Revista Chilena de Historia Natural, 2018
Background The invasive diatom Didymosphenia geminata (Lyngbye) M. Schmidt has received considerable attention in recent years due to its rapid geographic expansion and massive proliferation, which have altered habitat availability for benthic species ...
Fabián Figueroa, Pablo Pedreros, Fabiola Cruces, Roberto Abdala-Díaz, Víctor Hernández, José Becerra, Roberto Urrutia   +6 more
doaj   +1 more source