Results 101 to 110 of about 974,120 (307)
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
Optimal Control and Shape Design: Theory and Applications
, 2003 This work focuses on the spectrum of problems connected with the analysis and the development of computational tools and models for engineering and scientific applications.
Lewis, Brian M.
core
Combined shape and non-shape sensitivity for optimal design of metal forming operations
Computer Assisted Methods in Engineering and Science, 2023 Shape and non-shape optimization is carried out for metal forming processes. This means a unified treatment of both shape parameters and other process parameters which are assumed to be design variables.
Horacio J. Antunez, Maciej Kowalczyk
doaj
FEBS Letters, EarlyView.The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson +6 more
wiley +1 more source
, 2022 This book aims at encompassing the panorama of design tools being developed, tested and adopted by researchers and professors at the Department of Design of Politecnico di Milano.
Bruno, Carmen +4 more
core
Electron transfer between complexes III and IV in S. cerevisiae mitochondrial membranes
FEBS Letters, EarlyView.Mitochondrial oxidative phosphorylation in S. cerevisiae mitoplasts is limited by complex IV catalytic capacity, rather than two‐dimensional cytochrome c diffusion. At physiological cytochrome c : supercomplex ratios at salinity equivalent to that of 20 mm monovalent salt, activity is maximized, indicating that this low ionic strength accurately mimics
Ana Paula Lobez +2 more
wiley +1 more source
Manifold Learning for Aerodynamic Shape Design Optimization
AerospaceThe significant computational cost incurred due to the iterative nature of Computational Fluid Dynamics (CFD) in traditional aerodynamic shape design frameworks poses a major challenge, especially in the context of modern integrated design requirements ...
Boda Zheng +3 more
doaj +1 more source
Shape and Being Shaped: Sketching with Haptics in Soma Design.
, 2023 Att skissa är en integrerad del av designprocessen, särskilt i den tidiga idéutformnings- fasen, där fokus ligger på att uttrycka idéer, tankar och känslor, låta dem ta form och göra det möjligt att dela dem med andra för att driva designprocessen framåt.
openaire +2 more sources
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source