Results 81 to 90 of about 974,120 (307)
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Supporting Knitwear Design Using Case-Based Reasoning [PDF]
, 2009 Organised by: Cranfield UniversityKnitwear design is a creative activity that is hard to automate using the computer. The production of the associated knitting pattern, however, is repetitive, time-consuming and error-prone, calling for automation. Our
Richards, P., Ekárt, A.
core
Shape design optimization of 2-dimensional inlaid structures
Nihon Kikai Gakkai ronbunshu, 2016 Owning to the different mechanical behaviors of the instinct materials, inlaid structures composed of dissimilar materials have potential for industrial application, such as vibration suppression.
Masatoshi SHIMODA +2 more
doaj +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Supporting reinterpretation in computer-aided conceptual design
, 2008 This paper presents research that aims to inform the development of computational tools that better support design exploration and idea transformation - key objectives in conceptual design.
Prats, M. +9 more
core
Bridging the gap between design and engineering in packaging development [PDF]
, 2009 Organised by: Cranfield UniversityPackaging designers often come up with splendid design proposals, without being aware of technical, marketing or economical restrictions. This leads to infeasible proposals, so many packaging design projects fail.
ten Klooster, R. +3 more
core
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Journal of Differential Geometry, 2010 In this paper we study the problem of recovering the reflecting surface in a reflector system which consists of a point light source, a reflecting surface, and an object to be illuminated. This problem involves a fully nonlinear partial differential equation of Monge- Ampère type, subject to a nonlinear second boundary condition. A weak solution can be
Karakhanyan, Aram, Wang, Xi-Jia
openaire +4 more sources
Influence of the shape on the consumers perception of the packaging attributes
Journal of Graphic Engineering and Design, 2015 Packaging for fast moving consumer goods (FMCG) demands constant attention in order to stay competitive in modern dynamic markets. FMCG consumers do not think about the purchasing product until they enter the place of purchase. This emphasizes importance
Gojko Vladić +4 more
doaj