Results 71 to 80 of about 974,120 (307)

The Fractal shapes in Islamic design & its effects on the occupiers of the interior environment (case study: El Sultan Hassan mosque in Cairo)

open access: yesJournal of Architecture, Art & Humanistic Science, 2020
The Islamic civilization are distinct for using the art of geometry in their creative designs. In the early Islamic period, designs used simple forms like square shape, gradually more geometrical transformations are applied such as; shapes subtraction ...
Doaa Ismail Ismail Attia
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Shape Machine and Interpreters

open access: yes, 2019
Presented as part of the Shape Machine Symposium on April 11, 2019 at 10:34 a.m. in the John & Joyce Caddell Building, Flex Space.Tzu-Chieh Kurt Hong is a PhD candidate in the School of Architecture at the Georgia Institute of Technology.
Hong, Tzu-Chieh Kurt
core  

Progress and Challenges in Generative Product Design: A Review of Systems

open access: yesComputers, 2020
Design is a challenging task that is crucial to all product development. Advances in design computing may allow machines to move from a supporting role to generators of design content. Generative Design systems produce designs by algorithms and offer the
James Mountstephens, Jason Teo
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Shape Machine and Parametrics

open access: yes, 2019
Presented as part of the Shape Machine Symposium on April 11, 2019 at 11:15 a.m. in the John & Joyce Caddell Building, Flex Space.James Park is a PhD Student in the School of Architecture at the Georgia Institute of Technology. His research investigates
Park, James
core  

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Influence of Rotor Structure and Number of Phases on Torque and Flux Weakening Characteristics of V-Shape Interior PM Electrical Machine [PDF]

open access: yes, 2011
Post publication CONGRES EVER2011 (International Conference and Exhibition on Ecological Vehicles and Renewable Energies 2011)This paper investigates the influence of the rotor structure on torque and flux weakening region of V-shape IPM (interior ...
VIGIER, Thimoté   +4 more
core  

Generative urban design using shape grammar and block morphological analysis

open access: yesFrontiers of Architectural Research, 2020
The significant challenges that urban design faces when moving forward into this new digital era involve the increasingly massive and complex projects that must be analyzed and developed.
Xiao Wang, Yacheng Song, Peng Tang
doaj   +1 more source

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