Results 61 to 70 of about 974,120 (307)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Evolutionary design using grammatical evolution and shape grammars : designing a shelter

, 2010
A new evolutionary design tool is presented, which uses shape grammars and a grammar-based form of evolutionary computation, grammatical evolution (GE).
John Mark Swafford, Swafford, John Mark, James McDermott, Hemberg, Erik, Michael O'Neill, Brabazon, Anthony, Ciaran McNally, Martin Hemberg, McDermott, James, Hemberg, Martin, Byrne, Jonathan, Erik Hemberg, Anthony Brabazon, Elizabeth Shotton, O\u27Neill, Michael, Jonathan Byrne, O'Neill, Michael, McNally, Ciaran, Shotton, Elizabeth   +18 more
core   +1 more source

Solar‐Driven Evaporator With “Starburst Turbine” Design Featuring Directional Salt Crystallization, Antibacterial, and Catalytic Multifunctionality for Efficient Water Purification

Advanced Science
Facing the global challenge of water scarcity, solar‐driven desalination is considered a sustainable technology for obtaining freshwater from seawater.
Jiahui Yu, Lele Li, Yuxuan Liu, Jie Wen, Shu Liu, Jiye Li, Junyi Ning, Changxiang Shao, Tao Wu, Bing Liu   +9 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Efficient handling of stability problems in shell optimization by asymmetric ‘worst-case’ shape imperfection [PDF]

, 2008
The paper presents an approach to shape optimization of proportionally loaded elastic shell structures under stability constraints. To reduce the stability-related problems, a special technique is utilized, by which the response analysis is always ...
Brank, Boštjan, Kegl, Marko, Harl, Branko, Oblak, Maks   +3 more
core   +1 more source

Implicit Shape Parameterization for Kansei Design Methodology

Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2007
Implicit shape parameterization for Kansei design is a procedure that use 3D-models, or concepts, to span a shape space for surfaces in the automotive field. A low-dimensional, yet accurate shape descriptor was found by Principal Component Analysis of an
Andreas Kjell NORDGREN, Hideki AOYAMA
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Shape optimization method for nozzle design

Computer Assisted Methods in Engineering and Science, 2023
The optimization of the nozzle shape was carried out using the finite element incompressible viscous flow solver, with discretization of total derivative, with the originally developed software.
Zoran Mrša, Gorazd Medić
doaj