Results 111 to 120 of about 974,120 (307)

Transfer Optimization for Efficient Aerodynamic Shape Design

Aerospace
Constructing rapid aerodynamic shape optimization frameworks based on high-fidelity reduced-order models (ROMs) has become a mainstream solution for alleviating the excessive computational cost of full-order simulation-based design, especially for ...
Boda Zheng, Weigang Yao, Min Xu
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Shape Machine Symposium - Panel and Final Discussion

, 2019
Presented as part of the Shape Machine Symposium on April 11, 2019 at 3:30 p.m. in the John & Joyce Caddell Building, Flex Space.Christopher F. Earl is a Professor of Design at The Open University.
Earl, Chris, Stiny, George, Knight, Terry, McKay, Alison, Shelden, Dennis R., Flemming, Ulrich   +5 more
core  

Die Design for Near-Net Shape Forging

Acta Polytechnica, 2003
This paper discusses the use of conventional forging equipment for the manufacture of precise forging without flash. An analysis is presented of the factors influencing the forging process and the conditions for establishing this technique in a forge ...
J. Čermák, G. Gráf
doaj  

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Shape optimisation using evolutionary techniques in product design

, 2007
Shape or surface optimisation in product design is a very essential and time-consuming process, especially at the conceptual design stage. In this paper, we introduce a research project aiming to develop an evolutionary design system capable of evolving ...
Jian Sun, Tang, Ming Xi, Tang Mingxi, Frazer, JH, John H. Frazer, Tang, M, Frazer, John H., Sun, Jian, Sun, J   +8 more
core   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates

FEBS Letters, EarlyView.
Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino, Giuliana Fusco, Alfonso De Simone   +2 more
wiley   +1 more source

The design of adaptive structures for wing morphing

, 2006
This research is concerned with the design of adaptive structures for achieving global multi-shape morphing aerodynamic configurations, by using slender structures.
Ursache, Narcis M., Ursache, Narcis M
core