Results 121 to 130 of about 3,495,060 (298)
Grid sensitivity capability for large scale structures [PDF]
The considerations and the resultant approach used to implement design sensitivity capability for grids into a large scale, general purpose finite element system (MSC/NASTRAN) are presented.
Nagendra, Gopal K. +1 more
core +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
The design and construction of the CAD-1 airship [PDF]
, 1975 The background history, design philosophy and Computer application as related to the design of the envelope shape, stress calculations and flight trajectories of the CAD-1 airship, now under construction by Canadian Airship Development Corporation are ...
Duncan, J. L. +2 more
core +1 more source
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Balanced Shape Design of an Eccentric Gear
Jixie chuandong, 2015 A balanced shape design of an eccentric gear is presented,by using the leverage balanced design principle,the balance force on gear tooth is achieved by changing gear shape in the software of UG.After eccentric gear design,the original mechanical ...
Wei Jiangbo
doaj
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Shape Optimal Design of Involute Gear Fillet
Jixie chuandong, 1996 描述齿根过渡曲线的有理ＥＥ样条的内权因子为设计变量，齿根过渡曲线区域最大ＶｏｎＭｉｓｅｓ应力极小化为目标，应用自适应有限元分析技术，对齿极过渡曲线进行了形状优化设计，获得了具有较高齿根弯曲强度的齿根渡曲线。
郭太勇, 梁迎春, 黎文勇
doaj
Shape optimization of three-dimensional stamped and solid automotive components [PDF]
The shape optimization of realistic, 3-D automotive components is discussed. The integration of the major parts of the total process: modeling, mesh generation, finite element and sensitivity analysis, and optimization are stressed.
Bennett, J. A. +2 more
core +1 more source