Results 121 to 130 of about 264,907 (315)
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
平均コンプライアンス最小化を目的とした熱弾性場の形状最適化 [PDF]
, 2011 This paper presents a numerical analysis method for shape optimization in order to achieve stiffness maximization in thermoelastic fields. Mean compliance is used as an objective functional for the shape optimization problem.
片峯, 英次 +7 more
core +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Robust optimization utilizing the second-order design sensitivity information [PDF]
, 2010 This paper presents an effective methodology for robust optimization of electromagnetic devices. To achieve the goal, the method improves the robustness of the minimum of the objective function chosen as a design solution by minimizing the second-order ...
Kim, Heung-Geun +11 more
core +1 more source
Molecular Oncology, EarlyView.Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou +12 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
Investigation on Adjoint Based Gradient Computations for Realistic 3d Aero-Optimization
, 2010 A discrete adjoint method for e ciently computing gradients for aerodynamic shape op- timizations is presented. The chain itself involves an unstructured mesh Reynolds-Averaged Navier-Stokes solver, and is suitable for the optimization of complex ...
Brezillon, Joel +3 more
core
, 2001 [Abstract]: This paper presents a performance index for topology and shape optimization of plate bending problems with displacement constraints. The performance index is developed based on the scaling design approach.
Xie, Yi Min +2 more
core +1 more source
Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source