Results 111 to 120 of about 264,907 (315)

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Shape Optimization of Free-form Shells Considering Strain Energy and Algebraic Invariants of Parametric Surface

, 2009
p. 525-535A new approach is proposed for shape optimization of shell surfaces, where requirements on the aesthetic aspect and the constructability as well as the structural rationality are simultaneously considered in the problem formulation. The surface
FUJITA, Shinnosuke, OHSAKI, Makoto
core  

Minimization of railhead edge stresses through shape optimization

, 2013
The railhead is severely stressed under the localized wheel contact patch close to the gaps in insulated rail joints. A modified railhead profile in the vicinity of the gapped joint, through a shape optimization model based on a coupled genetic algorithm
Zong, Nannan, Dhanasekar, Manicka
core   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Shape optimization with the biological growth method: A parameter study

, 1996
Studies the effect of parameters controlling the biological growth method by applying it to the classical optimization problem of a plate with a central hole under biaxial stress state.
Guneri, A, Tekkaya, AE
core   +1 more source

Shape optimization method for nozzle design

Computer Assisted Methods in Engineering and Science, 2023
The optimization of the nozzle shape was carried out using the finite element incompressible viscous flow solver, with discretization of total derivative, with the originally developed software.
Zoran Mrša, Gorazd Medić
doaj  

The optimal shape of roots [PDF]

Complexity, 2010
Martin Singleton, Gregor Heiss, Alfred W. Hübler   +2 more
openaire   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Gradient-Based Aero-Stealth Optimization of a Simplified Aircraft

Fluids
Modern fighter aircraft increasingly need to conjugate aerodynamic performance and low observability. In this paper, we showcase a methodology for a gradient-based bidisciplinary aero-stealth optimization.
Charles Thoulon, Gilbert Roge, Olivier Pironneau   +2 more
doaj   +1 more source