Results 111 to 120 of about 8,515,340 (337)

The Influence of the Load Term of the Strain Energy Sensitivity in the Shell Shape Optimization

Applied Sciences, 2020
The sensitivity method is a type of effective shape optimization method and the strain energy is a frequently used objective function. The change of a surface shape inevitably causes a change in its quality.
Baoshi Jiang, Changyu Cui, Jianghong Wang   +2 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Reconstruction of Tesla micro-valve using topological sensitivity analysis

Advances in Nonlinear Analysis, 2019
In this paper, we deal with topology optimization attributed to the non stationary Navier-Stokes equations. We propose an approach where we analyze the sensitivity of a shape function relating to a perturbation of the flow domain.
Abdelwahed M., Chorfi N., Malek R.
doaj   +1 more source

A Shape Optimization Method for Part Design Derived from the Buildability Restrictions of the Directed Energy Deposition Additive Manufacturing Process

Designs, 2020
The design methodologies and part shape algorithms for additive manufacturing (AM) are rapidly growing fields, proven to be of critical importance for the uptake of additive manufacturing of parts with enhanced performance in all major industrial sectors.
Andreas K. Lianos, Harry Bikas, Panagiotis Stavropoulos   +2 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Turnpike in optimal shape design

IFAC-PapersOnLine, 2019
Abstract We investigate the turnpike problem in optimal control, in the context of time-evolving shapes. We focus here on the heat equation model where the shape acts as a source term, and we search the optimal time-varying shape, minimizing a quadratic criterion.
Lance, G., Trélat, E., Zuazua, E.
openaire   +2 more sources

Aerodynamic Shape Optimization of Natural-Laminar-Flow Wing Using Surrogate-Based Approach

AIAA Journal, 2018
Aerodynamic shape optimization of a swept natural-laminar-flow wing in the transonic regime is still challenging.
Zhonghua Han, J. Chen, Ke-shi Zhang, Zhen-Ming Xu, Zhende Zhu, Wenping Song   +5 more
semanticscholar   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

On a classical spectral optimization problem in linear elasticity

, 2014
We consider a classical shape optimization problem for the eigenvalues of elliptic operators with homogeneous boundary conditions on domains in the $N$-dimensional Euclidean space.
B Kawohl, D Bucur, D Bucur, D Buoso, D Buoso, D Mazzoleni, E Oudet, G Buttazzo, J Serrin, K Deimling, LM Chasman, MS Ashbaugh, NS Nadirashvili, P Grinfeld, PD Lamberti, PD Lamberti, PD Lamberti, PD Lamberti, SA Wolf   +18 more
core   +1 more source