Results 101 to 110 of about 264,907 (315)
PDE-constrained shape optimization: Towards product shape spaces and stochastic models
, 2022 Shape optimization models with one or more shapes are considered in this chapter. Of particular interest for applications are problems in which a so-called shape functional is constrained by a partial differential equation (PDE) describing the underlying
Geiersbach, Caroline +2 more
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The Influence of the Load Term of the Strain Energy Sensitivity in the Shell Shape Optimization
Applied Sciences, 2020 The sensitivity method is a type of effective shape optimization method and the strain energy is a frequently used objective function. The change of a surface shape inevitably causes a change in its quality.
Baoshi Jiang +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
, 2009 Within the next few years, numerical shape optimization based on high fidelity methods is likely to play a strategic role in future aircraft design. In this context, suitable tools have to be developed for solving aerodynamic shape optimization problems,
Dwight, Richard P. +5 more
core
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
, 2022 S.1658-1689Shape optimization based on shape calculus has received a lot of attention in recent years, particularly regarding the development, analysis, and modification of efficient optimization algorithms.
Blauth, S.
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Turnpike in optimal shape design
IFAC-PapersOnLine, 2019 Abstract We investigate the turnpike problem in optimal control, in the context of time-evolving shapes. We focus here on the heat equation model where the shape acts as a source term, and we search the optimal time-varying shape, minimizing a quadratic criterion.
Lance, G., Trélat, E., Zuazua, E.
openaire +2 more sources
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
On the combined effect of design-space dimensionality reduction and optimization methods on shape optimization efficiency [PDF]
, 2018 The curse of dimensionality represents a relevant issue in simulation-based shape optimiza-tion, especially when complex physics and high-fidelity computationally-expensive solvers areinvolved in the process and a global optimum is sought after. In order
Andrea Serani +2 more
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Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source