Results 81 to 90 of about 264,907 (315)

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

The Implications of the Use of Composite Materials in Electromagnetic Device Topology and Shape Optimization [PDF]

, 2008
The use of composite materials provides electromagnetic device designers with serious challenges. While such materials have the potential of allowing novel threedimensional topologies to be used, as well as providing major advantages in recycling at the ...
Lowther, D. A., D.-H. Kim, Lowther, D.A., Kim, D.H., Sykulski, J. K., J.K. Sykulski, D.A. Lowther, Sykulski, J.K., Kim, D. H.   +8 more
core   +1 more source

Non-Parametric Shape Optimization of a Football Boot Bottom Plate

Proceedings, 2020
This paper describes the non-parametric shape optimization process for a football boot bottom plate. The non-parametric shape optimization process changes the nodes’ location of a model and outputs an optimum shape, which satisfies an optimization ...
Jeong-Ro Lee, Andy Harland, Jonathan Roberts   +2 more
doaj   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Structural shape optimization using evolution strategies

, 1999
Summarization: The objective of this paper is to investigate the efficiency of combinatorial optimization methods and in particular algorithms based on evolution strategies, when incorporated into shape optimization problems.
Papadrakakis, Manolis(http://viaf.org/viaf/305343444), Yiannis Tsompanakis, Tsompanakis, Y, Papadrakakis, M, Lagaros, Nikos D(http://viaf.org/viaf/269404562), Lagaros, ND   +5 more
core   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Results of the Shape Optimization of Rotating Electric Machines using Isogeometric Analysis

, 2020
This repository contains data and Matlab/Octave code to generate the images from the paper "Shape Optimization of Rotating Electric Machines using Isogeometric Analysis and Harmonic Stator-Rotor Coupling" and the original and optimized rotor geometryThis
Melina Merkel, Peter Gangl, Sebastian Schöps   +2 more
core   +1 more source

Geodesic Convolutional Shape Optimization

CoRR, 2018
Aerodynamic shape optimization has many industrial applications. Existing methods, however, are so computationally demanding that typical engineering practices are to either simply try a limited number of hand-designed shapes or restrict oneself to shapes that can be parameterized using only few degrees of freedom.
Pierre Baqué, Edoardo Remelli, François Fleuret, Pascal Fua   +3 more
openaire   +3 more sources

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source