Results 81 to 90 of about 8,515,340 (337)

Evaluating the Utility of Paired Tumor and Germline Targeted DNA Sequencing for Pediatric Oncology Patients: A Single Institution Report

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate the diagnostic yield and utility of universal paired tumor–normal multigene panel sequencing in newly diagnosed pediatric solid and central nervous system (CNS) tumor patients and to compare the detection of germline pathogenic/likely pathogenic variants (PV/LPVs) against established clinical referral criteria for cancer ...
Natalie Waligorski   +9 more
wiley   +1 more source

Fundamental investigation on free-form optimization of vibration lures

open access: yesNihon Kikai Gakkai ronbunshu, 2021
Lure fishing is a special fishing method that using artificial fishing lures as fish baits and has become more and more popular all over the world. Vibration lures are a regular item among fishing lures that perform vibration action in the water for ...
Jin-Xing SHI   +2 more
doaj   +1 more source

Shape Optimization Problems with Internal Constraint [PDF]

open access: yes, 2011
We consider shape optimization problems with internal inclusion constraints, of the form $$\min\big\{J(\Omega)\ :\ \Dr\subset\Omega\subset\R^d,\ |\Omega|=m\big\},$$ where the set $\Dr$ is fixed, possibly unbounded, and $J$ depends on $\Omega$ via the ...
Bucur, Dorin   +2 more
core  

Outcomes of Live Virus Vaccination in Patients With Vascular Anomalies Being Treated With Sirolimus

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background Live vaccination in patients with vascular anomalies (VA) receiving sirolimus remains controversial due to immunosuppressive effects and theoretical risks. Procedure This single‐center retrospective study included patients with VA less than 4 years old at the start of sirolimus therapy who were incompletely vaccinated.
Svatava Merkle   +5 more
wiley   +1 more source

Shape optimization of joining interface profile for maximizing the tensile load carrying capacity of scarf jointed plates of dissimilar materials

open access: yesNihon Kikai Gakkai ronbunshu, 2021
The shape optimization of joining interface profile is performed for maximizing the tensile load carrying capacity of scarf jointed plates of dissimilar materials.
Hideki SEKINE, Hiroshi SHIRAHATA
doaj   +1 more source

Parameterization adaption for 3D shape optimization in aerodynamics [PDF]

open access: yes, 2014
When solving a PDE problem numerically, a certain mesh-refinement process is always implicit, and very classically, mesh adaptivity is a very effective means to accelerate grid convergence.
Majd, Badr Abou El
core   +3 more sources

‘They Need to Hear You Say It’: Healthcare Professionals’ Perspectives on Barriers and Enablers to End‐of‐Life Discussions With Adolescents and Young Adults With Cancer

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT End‐of‐life conversations with adolescents and young adults (AYAs) with cancer rarely occur without the guidance of healthcare professionals. As a part of the ‘Difficult Discussions’ study, focused on palliative care and advance care planning discussions with AYAs with cancer, we investigated the factors that healthcare professionals identify ...
Justine Lee   +9 more
wiley   +1 more source

Parameter Selection of Local Search Algorithm for Design Optimization of Automotive Rubber Bumper

open access: yesApplied Sciences, 2020
In rubber bumper design, the most important mechanical property of the product is the force–displacement curve under compression and its fulfillment requires an iterative design method.
Dávid Huri, Tamás Mankovits
doaj   +1 more source

Shape optimization of disc-type flywheels [PDF]

open access: yes, 1976
Techniques were developed for presenting an analytical and graphical means for selecting an optimum flywheel system design, based on system requirements, geometric constraints, and weight limitations.
Nizza, R. S.
core   +1 more source

Feasibility and Safety of High‐Dose Proton Re‐Irradiation in Recurrent Pediatric Central Nervous System Tumors: A Single‐Institution Retrospective Study

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose Pediatric central nervous system (CNS) tumors often recur despite multimodality therapy. Although re‐irradiation (re‐RT) has historically been limited by concerns for severe late toxicities, modern techniques have renewed interest in this approach. Proton therapy provides dosimetric advantages that may enable curative re‐treatment with
Jin‐Ho Song   +15 more
wiley   +1 more source

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