Results 61 to 70 of about 241,381 (266)
Fully turbulent discrete adjoint solver for non-ideal compressible flow applications
Journal of the Global Power and Propulsion Society, 2017 Non-Ideal Compressible Fluid-Dynamics (NICFD) has recently been established as a sector of fluid mechanics dealing with the flows of dense vapors, supercritical fluids, and two-phase fluids, whose properties significantly depart from those of the ideal ...
Salvatore Vitale +4 more
doaj +1 more source
Nihon Kikai Gakkai ronbunshu, 2021 The shape optimization of joining interface profile is performed for maximizing the tensile load carrying capacity of scarf jointed plates of dissimilar materials.
Hideki SEKINE, Hiroshi SHIRAHATA
doaj +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Shape optimization of an acoustic horn [PDF]
Computer Methods in Applied Mechanics and Engineering, 2003 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Bängtsson, Erik +2 more
openaire +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Shape Optimum Design by Basis Vector Method Considering Partial Shape Dependence
Applied Sciences, 2020 Regarding the case of complicated structural shape optimization, there are cases where there are partial shapes such as holes and irregularities inside the structure.
Qiong Wu +3 more
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Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Non-Parametric Shape Optimization of a Football Boot Bottom Plate
Proceedings, 2020 This paper describes the non-parametric shape optimization process for a football boot bottom plate. The non-parametric shape optimization process changes the nodes’ location of a model and outputs an optimum shape, which satisfies an optimization ...
Jeong-Ro Lee +2 more
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Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source