Results 71 to 80 of about 8,515,340 (337)

Real‐World Pediatric Blinatumomab Administration: Access to Outpatient Care Delivery and Impact of a Hospital‐Dispensed Model

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Blinatumomab has been shown to be highly effective for patients with pediatric B‐ALL and has recently become standard of care therapy. Due to its past use in the clinical trial setting, there is limited information available about real‐world administration.
Katelyn Oranges, Kelly A. Duffy, Sara McDonough, Evelyn Kurpiewski, R. Jennifer Randall, Allison Barz Leahy, Haley M. Newman, Joyce P. Lee, Stephen P. Hunger, Anne F. Reilly, David T. Teachey, Susan R. Rheingold, Daniel J. Zheng   +12 more
wiley   +1 more source

Shape optimization of a flexible beam with a local shape feature based on ANCF

Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2019
This paper proposes a shape optimization method of local shape features on a flexible beam modeled with the absolute nodal coordinate formulation (ANCF).
Gang HE, Kang GAO, Jun JIANG, Ruifeng LIU, Qian LI   +4 more
doaj   +1 more source

Sharp interface limit for a phase field model in structural optimization

, 2016
We formulate a general shape and topology optimization problem in structural optimization by using a phase field approach. This problem is considered in view of well-posedness and we derive optimality conditions.
Christoph Rupprecht, Claudia Hecht, Delfour M., Garcke H., Harald Garcke, Karchevsky A., Luise Blank, Modica L.   +7 more
core   +1 more source

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács, Zoltán Köllő, Balázs Gellért Karvaly, Mahmoud Obeidat, Rita Nagy, Péter Hegyi, Brigitta Teutsch, Eszter Tuboly, Miklós Garami   +8 more
wiley   +1 more source

Parameter-Free Shape Optimization: Various Shape Updates for Engineering Applications

Aerospace, 2023
In the last decade, parameter-free approaches to shape optimization problems have matured to a state where they provide a versatile tool for complex engineering applications.
Lars Radtke, Georgios Bletsos, Niklas Kühl, Tim Suchan, Thomas Rung, Alexander Düster, Kathrin Welker   +6 more
doaj   +1 more source

Second-order Shape Optimization for Geometric Inverse Problems in Vision [PDF]

, 2014
We develop a method for optimization in shape spaces, i.e., sets of surfaces modulo re-parametrization. Unlike previously proposed gradient flows, we achieve superlinear convergence rates through a subtle approximation of the shape Hessian, which is ...
Balzer, J., Soatto, S.
core   +1 more source

Suitable Spaces for Shape Optimization [PDF]

Applied Mathematics & Optimization, 2021
AbstractThe differential-geometric structure of the manifold of smooth shapes is applied to the theory of shape optimization problems. In particular, a Riemannian shape gradient with respect to the first Sobolev metric and the Steklov–Poincaré metric are defined.
openaire   +3 more sources

Adherence to Protocol Recommendations for Children With Wilms Tumour in Two Consecutive Studies in the United Kingdom and Ireland—Does Variation Matter?

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background and Aims Wilms tumour (WT) has excellent event‐free and overall survival (OS). However, small differences exist between countries participating in the same international study. This led us to examine variation in adherence to protocol recommendations as a potential contributing factor.
Suzanne Tugnait, R. Al‐Saadi, A. Lopez‐Cortes, K. Dzhuma, M. Oostveen, J. Brok, S. Irtan, M. Weeks, J. Bate, S. Baker, R. Williams, M. Powis, D. Saunders, O. Olsen, T. Watson, S. Shelmerdine, S. Vaidya, L. Howell, C. Duncan, G. M. Vujanic, C. Stiller, G. P. Balchin, T. Chowdhury, K. Pritchard‐Jones   +23 more
wiley   +1 more source

Morphology-Embedded Synergistic Optimization of Thermal and Mechanical Performance in Free-Form Single-Layer Grid Structures

Technologies
Free-form grid structures offer both aesthetic appeal and structural efficiency in long-span roof design and application, yet the potential of morphological design to optimize thermal performance has been long overlooked.
Bowen Hou, Baoshi Jiang, Bangjian Wang
doaj   +1 more source

Branching Structures in Elastic Shape Optimization

, 2017
Fine scale elastic structures are widespread in nature, for instances in plants or bones, whenever stiffness and low weight are required. These patterns frequently refine towards a Dirichlet boundary to ensure an effective load transfer.
D Cioranescu, G W Milton, L Modica, M P Bendsèe, N Lüthen, P Penzler, R Müller, S Nemat-Nasser   +7 more
core   +1 more source