Results 91 to 100 of about 264,907 (315)

Shape design optimization of 2-dimensional inlaid structures

Nihon Kikai Gakkai ronbunshu, 2016
Owning to the different mechanical behaviors of the instinct materials, inlaid structures composed of dissimilar materials have potential for industrial application, such as vibration suppression.
Masatoshi SHIMODA, Jin-Xing SHI, Genki KAWAE   +2 more
doaj   +1 more source

Shape optimization for tumor location

Computers & Mathematics with Applications, 2011
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Juan P. Agnelli, Claudio Padra, Cristina Vilma Turner   +2 more
openaire   +4 more sources

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Proposal of texture shape optimization algorithm under constant load condition and considerations on new shape update equation (Texture shape optimization for minimization of friction coefficient)

Journal of Fluid Science and Technology, 2020
An algorithm to optimize texture shape under constant load conditions and a shape update equation of the design variables are proposed. The tribological properties are improved by machining grooves and holes, termed“ texture ”, on frictional surfaces ...
Syuta SASAOKA, Takahiko KURAHASHI
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Reconstruction of Tesla micro-valve using topological sensitivity analysis

Advances in Nonlinear Analysis, 2019
In this paper, we deal with topology optimization attributed to the non stationary Navier-Stokes equations. We propose an approach where we analyze the sensitivity of a shape function relating to a perturbation of the flow domain.
Abdelwahed M., Chorfi N., Malek R.
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Shape optimization of metallic yielding devices for passive mitigation of seismic energy [PDF]

, 2010
Bi-directional Evolutionary Structural Optimization (BESO) is a well established topology optimization technique. This method is used in this paper to optimize the shape of a passive energy dissipater designed for earthquake risk mitigation.
Ghabraie, Kazem, Huang, Xiaodong, Xie, Yi Min, Chan, Ricky   +3 more
core   +1 more source