Results 41 to 50 of about 438,635 (219)

Application of Kansei Engineering and Box-Behnken response surface methodology for shape parameter design: A case study of wine glass

Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2015
Product appearance has become a more important influence on customers' preference in regards to product purchase. Not only do customers take into account functionality and cost, but also on aesthetic and affection value.
Chaiwat KITTIDECHA, Ashuboda Chandrajith MARASINGHE   +1 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Evidence for Non‐Stationarity in the GEV Shape Parameter When Modeling Extreme Rainfall

Water Resources Research
It is now well established that climate change is increasing the intensity of extreme rainfall. What is less well established is how best to model these changes.
Lalani Jayaweera, Conrad Wasko, Rory Nathan   +2 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Study on Dynamic Factors of Damped Beam Members Under Exponential Attenuation Loading

Buildings
Blast loading is characterized as an impact loading with exponential attenuation, while damping serves as an intrinsic parameter that affects the vibration effect of beam members. The linear attenuation for simplified blast loading and undamped situation
Xin Hong, Shaobo Geng, Rui Feng
doaj   +1 more source

具有简单G3条件的可调曲线曲面(Adjustable curves and surfaces with simple G3 conditions)

Zhejiang Daxue xuebao. Lixue ban, 2016
In order to make curves and surfaces have adjustable shape and simple G3 conditions,a kind of EI functions is defined recursively. Based on them, we construct EI curves and surfaces,which have the most properties of Bézier curves and surfaces. Owe to the
YANLanlan(严兰兰), YINGZhengwei(应正卫)   +1 more
doaj   +1 more source