Results 51 to 60 of about 438,635 (219)

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Renewed empirical formulas for estimating Weibull distribution parameters

Компьютерная оптика
The empirical formulas proposed in the literature for estimating the parameters of a two-parameter Weibull distribution, obtained using the equations of the moment method, are considered. It is noted that the formulas used to estimate the shape parameter
D.G. Asatryan
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

A Hybrid Elliptic Curve Cryptography Hill Cipher with Bézier like Coefficient Matrix for Secure Image Encryption

Mathematics
Secure image communication over public networks requires encryption methods that provide strong security guarantees while maintaining computational efficiency for practical deployment.
Syed Ahmad Aidil Adha Said Mad Zain, Md Yushalify Misro, Hailiza Kamarulhaili, Muhammad Rezal Kamel Ariffin   +3 more
doaj   +1 more source

Modelling of diameter distributions of Douglas (Pseudotsuga menziesii (Mirb.) Franco) stands

İstanbul Üniversitesi Orman Fakültesi Dergisi, 2016
In this study, Diameter distributions of Amance and Vallombrosa origin stands of Douglas were intendent modelling with two parameter Weibull probability density function having shape and scale parameters for different age periods.
Gafura Aylak Özdemir
doaj   +1 more source

A novel geometric modeling approach for cubic developable C-Bézier surfaces

Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2020
In this paper, a novel geometric modeling method is proposed to construct generalized cubic developable C-Bézier (GCDC-Bézier, for short) surfaces with shape parameters.
Gang HU, Huinan LI, Xianzhi HU
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Optimal shape parameter for meshless solution of the 2D Helmholtz equation

CT&F Ciencia, Tecnología & Futuro, 2019
The solution of the Helmholtz equation is a fundamental step in frequency domain seismic imaging. This paper deals with a numerical study of solutions for 2D Helmholtz equation using a Gaussian radial basis function-generated finite difference scheme ...
Mauricio Alejandro Londoño-Arboleda, Hebert Montegranario-Riascos   +1 more
doaj   +1 more source