Results 61 to 70 of about 451,392 (314)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

On Monitoring of the Shape Parameter of the Inverse Gaussian Distribution via Memoryless Chart Under Bayesian Setup

open access: yesIEEE Access
The Inverse Gaussian distribution (IGD) is a probability distribution with several applications in various fields. The proposed study is prone to consider the problem of monitoring the shape parameter of IGD using the Bayesian method.
Tahir Abbas   +3 more
doaj   +1 more source

Shape parameters of a floating bubble

open access: yesPhysics of Fluids, 2018
For a floating bubble, in the range of Bond numbers based on an equivalent spherical radius, 0 < Boe < 1, we present analytical expressions for various shape parameters of the bubble as functions of Boe. Expressions are obtained for the radius of the rim Rr, the radius of the thin film cap Rc, the height of the top of the cap from the rim
Baburaj A. Puthenveettil   +3 more
openaire   +2 more sources

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

The Mystery of the Shape Parameter

open access: yes, 2010
In this paper we present criteria for the optimal choice of the shape parameter c contained in the famous radial function multiquadrics.
openaire   +2 more sources

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Equivalent Gini coefficient, not shape parameter!

open access: yes, 2023
In a recent contribution in this journal, Gagolewski et al. (Scientometrics 127(5): 2829– 2845, 2022) study a new model for representing a rank size distribution – the so-called 3DSI (3 dimensions of scientific impact) model.
Bertoli-Barsotti, Lucio
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Biquadratic TC-Bézier Curves with Shape Parameter

open access: yes, 2011
Shape controlling is a popular topic in curves and surfaces design with free form. In this paper, a new curve, to be called Biquadratic TC-Bézier curves with shape parameter , is constructed in the space .
Xu Min Liu, Xian Peng Yang, Yan Ling Wu
core   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

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