Results 61 to 70 of about 1,975,441 (290)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

The Shape Parameter in the Shifted Surface Spline—A Sharp and Friendly Approach

open access: yesMathematics
This is a continuation of our previous study on the shape parameter contained in the shifted surface spline. We insist that the data points be purely scattered without meshes and the domain can be of any shape when conducting function interpolation by ...
Lin-Tian Luh
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Identification of rolling resistance as a shape parameter in sheared granular media

open access: yes, 2011
Using contact dynamics simulations, we compare the effect of rolling resistance at the contacts in granular systems composed of disks with the effect of angularity in granular systems composed of regular polygonal particles.
Azema, Émilien   +3 more
core   +4 more sources

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

On Monitoring of the Shape Parameter of the Inverse Gaussian Distribution via Memoryless Chart Under Bayesian Setup

open access: yesIEEE Access
The Inverse Gaussian distribution (IGD) is a probability distribution with several applications in various fields. The proposed study is prone to consider the problem of monitoring the shape parameter of IGD using the Bayesian method.
Tahir Abbas   +3 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

$W$ : an alternative phenomenological coupling parameter for model systems

open access: yes, 2010
We introduce a parameter $W(\beta,L)= (\pi\,\langle |m| \rangle^2/\langle m^2 \rangle - 2)/(\pi-2)$ which like the kurtosis (Binder cumulant) is a phenomenological coupling characteristic of the shape of the distribution $p(m)$ of the order parameter $m$.
Campbell, I. A., Lundow, P. H.
core   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

The finite-temperature phase structure of lattice QCD with twisted-mass Wilson fermions [PDF]

open access: yes, 2012
We report progress in our exploration of the finite-temperature phase structure of two-flavour lattice QCD with twisted-mass Wilson fermions and a tree-level Symanzik-improved gauge action for a temporal lattice size Nt = 8.
Ilgenfritz, Ernst-Michael   +6 more
core  

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