Results 51 to 60 of about 998,789 (338)

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

open access: yesMolecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser   +14 more
wiley   +1 more source

Multidimensional Model of Surface Waviness Treated by Shaping Cutter

open access: yesProcedia Engineering, 2017
Abstract The article observes the regression model of waviness of the treated profile surface resulting from the planning and implementation of multidimensional experiment. The analytical dependences linking waviness of the treated surface with elements of the profile milling mode and design parameters of the shaping cutting tool were determined ...
V.G. Gusev, A.A. Fomin
openaire   +1 more source

Portable milling tool Patent [PDF]

open access: yes, 1968
Description of portable milling tool for milling tube or pipe ends to desired shape and ...
Spier, R. A.
core   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

open access: yesMolecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié   +16 more
wiley   +1 more source

Experimental study on the influence of cutting distance on the rock-breaking features of pick-shaped cutter

open access: yesGong-kuang zidonghua, 2023
The pick-shaped cutter is the most widely used cutter type in mining machinery such as roadheader and coal mining machine. In the actual cutting process, the pick-shaped cutter mainly works under the multi-tooth coupling cutting condition.
LIU Bin, LI Xuefeng
doaj   +1 more source

Hole cutter [PDF]

open access: yes, 1975
An adjustable hole cutter is described for use in forming circular openings in workpieces. The hole cutter is characterized by a mount of a substantially planar configuration, positionable into a plane paralleling the working plane of a selected ...
Newby, D. T., Thornton, G. E.
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

open access: yesMolecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker   +16 more
wiley   +1 more source

Finite element modelling of rock mass cutting by cutters for PDC drill bits

open access: yesPetroleum Exploration and Development, 2015
A finite element model of the process of polycrystalline diamond compact (PDC) drill bit cutters cutting rocks was built, and the rock linear and circular cutting processes for different shapes of PDC drill bit cutters were simulated.
T O Pryhorovska   +2 more
doaj   +1 more source

Screening for lung cancer: A systematic review of overdiagnosis and its implications

open access: yesMolecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz   +12 more
wiley   +1 more source

Grinding arrangement for ball nose milling cutters [PDF]

open access: yes, 1974
A grinding arrangement for spiral fluted ball nose end mills and like tools includes a tool holder for positioning the tool relative to a grinding wheel.
Burch, C. F.
core   +1 more source

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